[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100599775":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":15,"locations":21,"responsibleParty":42,"collaborators":10,"id":45,"slug":46,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":10,"eligibilityCriteria":51,"healthyVolunteers":47,"sex":52,"minAge":53,"maxAge":10,"enrollmentInfo":54,"targetDuration":57,"studyType":58,"phases":10,"briefSummary":59,"conditions":60,"keywords":10,"overallStatus":24,"whyStopped":10,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":73},{"fullName":5,"class":6},"Peking University First Hospital","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"AKI group\u002FCKD group",null,"1. patients diagnosed with AKI after radical nephrectomy.\n2. patients diagnosed with the new onset\u002Fworsening of CKD after radical nephrectomy.",{"label":13,"type":10,"description":14,"interventionNames":10},"non-AKI group\u002Fnon-CKD group","1. patients without AKI after radical nephrectomy.\n2. patients without new onset\u002Fworsening of CKD after radical nephrectomy.",[16],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},"Qiongfang Wu, MD","CONTACT","8610 83572460","wuqf91@163.com",[22],{"facility":23,"status":24,"city":25,"state":26,"zip":27,"country":28,"countryCode":29,"cosmosGeoPoint":30,"geoPoint":35,"contacts":36},"Department of Anesthesiology and Critical Care Medicine, Peking University First Hospital","RECRUITING","Beijing","Beijing Municipality","100034","China","CN",{"type":31,"coordinates":32},"Point",[33,34],116.39723,39.9075,{"lat":34,"lon":33},[37,41],{"name":38,"role":18,"phone":39,"phoneExt":10,"email":40},"Dong-Xin Wang, MD, PhD","8610 83572784","wangdongxin@hotmail.com",{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},{"type":43,"investigatorFullName":44,"investigatorTitle":5,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Qiongfang Wu","100599775","novel-biomarkers-and-postoperative-kidney-injury-in-radical-nephrectomy-100599775",false,"NCT07088874","Novel Biomarkers and Postoperative Kidney Injury in Radical Nephrectomy","Novel Biomarkers to Predict Acute Kidney Injury and Chronic Kidney Disease After Radical Nephrectomy: an Exploratory Prospective Cohort Study","Inclusion Criteria:\n\n* Age ≥18 years;\n* Scheduled to undergo unilateral radical nephrectomy.\n\nExclusion Criteria:\n\n* Solitary kidney;\n* Preoperative diagnosis of chronic kidney disease stages G4 or G5 (GFR \\\u003C30 mL\u002Fmin\u002F1.73m²);\n* Tumor invasion of the vena cava requiring thrombectomy;\n* Other conditions deemed by the investigator as unsuitable for participation in this study.","ALL","18 Years",{"count":55,"type":56},60,"ESTIMATED","1 Year","OBSERVATIONAL","The incidence of acute kidney injury (AKI) after radical nephrectomy exceeds 40%. Currently, the KDIGO criteria are the recognized diagnostic standard for AKI. These criteria primarily use serum creatinine and urine output as key indicators, but both parameters have certain limitations, such as delayed response, insensitivity, and inaccuracy. This study aims to simultaneously monitor perioperative novel renal damaging, stressful, and functional biomarkers in patients undergoing radical nephrectomy, and to investigate their predictive value for AKI and postoperative 1-year chronic kidney disease (CKD).",[61,62,63],"Nephrectomy","Acute Kidney Injury","Biomarker","2025-08-31",{"date":66,"type":67},"2025-09-08","ACTUAL",{"date":69,"type":67},"2025-08-02",{"date":71,"type":56},"2027-07-30",{"name":5,"class":6},1]