[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100619939":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":10,"centralContacts":10,"locations":10,"responsibleParty":19,"collaborators":23,"id":30,"slug":31,"hasResults":32,"nctId":33,"briefTitle":34,"officialTitle":34,"acronym":35,"eligibilityCriteria":36,"healthyVolunteers":32,"sex":37,"minAge":38,"maxAge":10,"enrollmentInfo":39,"targetDuration":42,"studyType":43,"phases":10,"briefSummary":44,"conditions":45,"keywords":47,"overallStatus":49,"whyStopped":10,"lastUpdateSubmitDate":50,"lastUpdatePostDateStruct":51,"startDateStruct":54,"completionDateStruct":56,"leadSponsor":58,"locationsCount":10},{"fullName":5,"class":6},"Universidade do Porto","OTHER",[8],{"label":9,"type":10,"description":10,"interventionNames":11},"adults with Fabry disease",null,[12],"Procedure: PET scan of 68Ga-FAPI",[14],{"type":15,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"PROCEDURE","PET scan of 68Ga-FAPI","To assess myocardial fibroblast activation, all enrolled patients will undergo positron emission tomography\u002Fcomputed tomography (PET\u002FCT) imaging using the radiotracer \\[68Ga\\]Ga-FAPI. This tracer binds selectively to the fibroblast activation protein (FAP), expressed predominantly in activated cardiac fibroblasts involved in pathological myocardial remodelling.",[9],{"type":20,"investigatorFullName":21,"investigatorTitle":22,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","Núcleo de Apoio à Investigação Clínica - FMUP","Elisabete Martins",[24,25,28],{"name":5,"class":6},{"name":26,"class":27},"SOFIE","INDUSTRY",{"name":29,"class":27},"GE Healthcare","100619939","novel-diagnostic-and-prognostic-predictors-in-fabry-cardiomyopathy-proof-of-concept-in-a-rare-disease-100619939",false,"NCT07351136","Novel Diagnostic and Prognostic Predictors in Fabry Cardiomyopathy: Proof of Concept in a Rare Disease","FABRyCar","Inclusion Criteria:\n\n* Adult patients, over 18 years of age;\n* Diagnosis of Fabry disease\n\nExclusion Criteria:\n\n* Refusal to participate in the study","ALL","18 Years",{"count":40,"type":41},20,"ESTIMATED","5 Years","OBSERVATIONAL","In this work, we address the understanding of the signaling pathways involved in cardiac remodeling in human SCD through molecular imaging analysis with a fibrosis marker. Furthermore, we emphasize characterizing the cardiac remodeling process by analyzing proteomic data from SCD myocardial biopsies and by analyzing the profile of microRNAs associated with hypertrophic cardiomyopathy and their diagnostic and prognostic value.",[46],"Fabry Disease",[46,48],"FAPI","NOT_YET_RECRUITING","2026-01-09",{"date":52,"type":53},"2026-01-20","ACTUAL",{"date":55,"type":41},"2026-01-01",{"date":57,"type":41},"2026-03-31",{"name":21,"class":6}]