[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100590122":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":18,"locations":23,"responsibleParty":36,"collaborators":10,"id":38,"slug":39,"hasResults":40,"nctId":41,"briefTitle":42,"officialTitle":43,"acronym":44,"eligibilityCriteria":45,"healthyVolunteers":46,"sex":47,"minAge":48,"maxAge":10,"enrollmentInfo":49,"targetDuration":10,"studyType":52,"phases":10,"briefSummary":53,"conditions":54,"keywords":56,"overallStatus":26,"whyStopped":10,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":75},{"fullName":5,"class":6},"JaxBio Ltd","INDUSTRY",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"Lung cancer patients",null,"lung cancer patients will be recruited at diagnosis. Blood will be taken before surgery \u002F treatment and after surgery \u002F treatment at the indicated time points.",{"label":13,"type":10,"description":14,"interventionNames":10},"non-malignant lung disease","Non-malignant lung disease cohort includes patients with chronic lung disease such as COPD, or acute pneumonia, and will serve as a control group to identify lung cancer and distinguish it from other lung diseases.",{"label":16,"type":10,"description":17,"interventionNames":10},"Healthy controls","Healthy individuals will serve as a control group.",[19],{"name":20,"role":21,"phone":10,"phoneExt":10,"email":22},"Yael Michaeli, Ph.D.","CONTACT","yaelmi@jaxbio.com",[24],{"facility":25,"status":26,"city":27,"state":10,"zip":10,"country":28,"countryCode":29,"cosmosGeoPoint":30,"geoPoint":35,"contacts":10},"Sheba Medical Center","RECRUITING","Ramat Gan","Israel","IL",{"type":31,"coordinates":32},"Point",[33,34],34.81065,32.08227,{"lat":34,"lon":33},{"type":37,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100590122","novel-epigenetic-mapping-in-cell-free-dna-for-the-detection-of-lung-cancer-100590122",false,"NCT06963307","Novel Epigenetic Mapping in Cell-Free DNA for the Detection of Lung Cancer","LUMEN-Dx: Novel Epigenetic Mapping in Cell-Free DNA for the Detection of Lung Cancer","LumenDx","Inclusion Criteria:\n\n* Men and women over 18 years old.\n* Patients diagnosed with lung cancer before systemic therapy.\n* Patients with inconclusive LDCT findings.\n* Healthy volunteers.\n* Patients with chronic lung diseases (COPD, pulmonary emphysema, acute pneumonia).\n\nExclusion Criteria:\n\n* Subjects who did not sign a consent form.\n* Patients with cancer other than lung cancer.\n* Patients with HIV or hepatitis.\n* Patients with active autoimmune diseases (except lung-localized diseases).\n* Pregnant women or individuals unable to give informed consent.",true,"ALL","18 Years",{"count":50,"type":51},300,"ESTIMATED","OBSERVATIONAL","This trial is a multicenter, open-label, non-interventional controlled study to identify and characterize epigenetic signatures of lung cancer. The goal of this study is to develop a simple blood test that can detect lung cancer with high sensitivity, and assist in the early diagnosis and management of lung cancer.\n\nIn particular, the ability to assist existing methods in cancer diagnostics, predict response to treatment, and assess the success of treatment during and after treatment will be examined. In addition, the ability to assess minimal residual disease (MRD) will be evaluated, by taking blood after surgery to remove a tumor or after treatment, and testing whether there is any residual DNA from the tumor using the markers that are found.\n\nThe collection of patients and data will be conducted over a period of about a year and a half, with the aim of reaching approximately 300 participants, including patients with lung cancer before and after treatment\u002Fsurgery and control groups.",[55],"Lung Cancer, Non-Small Cell",[57,58,59,60,61,62,63,64,65],"lung cancer","liquid biopsy","cancer diagnostics","follow-up","minimal residual disease","cell-free DNA","epigenetics","DNA methylation","response to therapy","2025-04-30",{"date":68,"type":69},"2025-05-09","ACTUAL",{"date":71,"type":51},"2025-05",{"date":73,"type":51},"2026-11",{"name":5,"class":6},1]