[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100498115":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":54,"collaborators":11,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":62,"eligibilityCriteria":63,"healthyVolunteers":58,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":11,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":78,"overallStatus":40,"whyStopped":11,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Istituto Auxologico Italiano","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"[Phase 1] Stroke patients with upper-limb hemiparesis","EXPERIMENTAL",null,[13],"Device: Transcranial Magnetic Stimulation",{"label":15,"type":10,"description":11,"interventionNames":16},"[Phase 2] Patients with phantom limb pain (PLP)",[13],[18],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":23},"DEVICE","Transcranial Magnetic Stimulation","The standard PAS protocol will be compared with the mirrorPAS protocol.",[9,15],[24,25],"TMS","Paired associative stimulation",[27],{"name":28,"affiliation":29,"role":30},"Nadia Bolognini, PhD","Laboratorio di Neuropsicologia, IRCCS Istituto Auxologico Italiano","PRINCIPAL_INVESTIGATOR",[32],{"name":28,"role":33,"phone":34,"phoneExt":35,"email":36},"CONTACT","+390261911","6127","n.bolognini@auxologico.it",[38],{"facility":39,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Istituto Auxologico Italiano IRCCS","RECRUITING","Milan","Lombardy","20122","Italy","IT",{"type":47,"coordinates":48},"Point",[49,50],9.18951,45.46427,{"lat":50,"lon":49},[53],{"name":28,"role":33,"phone":34,"phoneExt":35,"email":36},{"type":55,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100498115","novel-non-invasive-brain-stimulation-techniques-in-neurological-rehabilitation-100498115",false,"NCT05766059","Novel Non-invasive Brain Stimulation Techniques in Neurological Rehabilitation","Novel Non-invasive Brain Stimulation Techniques in Neurological Rehabilitation: Cross-modal Paired Associative Stimulation (PAS) Protocols to Promote Plastic Reorganization in Stroke and Phantom Limb Pain Patients","StimNeuro","Inclusion criteria for stroke patients:\n\n* age from 18 to 85 years\n* single, unilateral, hemispheric stroke (cortical or sub-cortical areas)\n* stroke confirmed by neuroimaging (CT or MRI)\n* stroke at least 4 months before enrollment\n* hemiparesis of the upper limb resulting from stroke or hemianesthesia clinically documented\n\nExclusion criteria for stroke patients:\n\n* contraindications to TMS (Rossi et all, 2021)\n* other neurological conditions (e.g., Parkinson's Disease, Multiple Sclerosis, ALS)\n* other orthopedic condition that affected the hand (e.g., carpal tunnel syndrome)\n\nInclusion criteria for PLP patients:\n\n* age from 18 to 90 years\n* amputation of one part of the upper limb at least 2 months before enrollment\n* presence of stable phantom limb pain at least 2 months prior to enrollment\n\nExclusion criteria for PLP patients:\n\n* contraindications to TMS (Rossi et all, 2021)\n* other neurological, orthopedical or psychiatric conditions","ALL","18 Years","85 Years",{"count":68,"type":69},36,"ESTIMATED","INTERVENTIONAL",[72],"NA","Paired associative stimulation (PAS) is a non-invasive brain stimulation protocol, where two stimuli (a peripheral and a cortical one, the latter delivered with transcranial magnetic stimulation - TMS) are repeatedly associated to enhance plasticity in the brain. In the present study, a new cross-modal, visuo-motor PAS protocol - called \"mirror-PAS\"- will be tested as a possible non-invasive brain stimulation treatment in neurological rehabilitation to promote motor recovery and pain reduction.\n\nParticipants will perform the standard PAS targeting the motor system and the recently developed mirror-PAS in two separate sessions. The investigators will compare the possible effect of the protocols in terms of neurophysiological and behavioral outcomes to identify the optimal PAS method to enhance plasticity and promote sensory-motor function.",[75,76,77],"Stroke","Hemiparesis","Phantom Limb Pain",[20,79,75,80,81],"Paired Associative Stimulation","Motor cortex","Phantom limb pain","2025-09-11",{"date":84,"type":85},"2025-09-17","ACTUAL",{"date":87,"type":85},"2023-02-08",{"date":89,"type":69},"2026-09-30",{"name":5,"class":6},1]