[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100409809":3},{"organization":4,"armGroups":7,"interventions":28,"overallOfficials":66,"centralContacts":71,"locations":82,"responsibleParty":100,"collaborators":103,"id":106,"slug":107,"hasResults":108,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":10,"eligibilityCriteria":112,"healthyVolunteers":113,"sex":114,"minAge":115,"maxAge":10,"enrollmentInfo":116,"targetDuration":10,"studyType":119,"phases":10,"briefSummary":120,"conditions":121,"keywords":123,"overallStatus":85,"whyStopped":10,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":137},{"fullName":5,"class":6},"Western University, Canada","OTHER",[8,20,24],{"label":9,"type":10,"description":11,"interventionNames":12},"c-cigarette never users",null,"Includes 70 participants who are e-cigarette users who have never smoked combustible cigarettes.",[13,14,15,16,17,18,19],"Diagnostic Test: Hyperpolarized Xenon-129 MRI of the lungs","Diagnostic Test: Computed Tomography (CT)","Diagnostic Test: Pulmonary Function Tests (PFT)","Diagnostic Test: Cardiopulmonary exercise testing (CPET)","Diagnostic Test: Sputum analysis","Diagnostic Test: Blood analysis","Other: Questionnaires",{"label":21,"type":10,"description":22,"interventionNames":23},"former or current c-cigarette users","Includes 70 participants who are e-cigarette users who are also former or current combustible cigarette smokers.",[13,14,15,16,17,18,19],{"label":25,"type":10,"description":26,"interventionNames":27},"never smokers","Includes 10 participants who have never smoked e-cigarettes or combustible cigarettes.",[13,14,15,16,17,18,19],[29,36,42,48,54,58,62],{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"DIAGNOSTIC_TEST","Hyperpolarized Xenon-129 MRI of the lungs","Participants will be imaged using MRI using hyperpolarized xenon-129 gas as a contrast gas",[9,21,25],[35],"129Xe MRI",{"type":30,"name":37,"description":38,"armGroupLabels":39,"otherNames":40},"Computed Tomography (CT)","Participants will undergo a CT scan of the thoracic cavity",[9,21,25],[41],"CT",{"type":30,"name":43,"description":44,"armGroupLabels":45,"otherNames":46},"Pulmonary Function Tests (PFT)","Participants will have their lung function evaluated using PFT",[9,21,25],[47],"PFT",{"type":30,"name":49,"description":50,"armGroupLabels":51,"otherNames":52},"Cardiopulmonary exercise testing (CPET)","Participants will perform cardiopulmonary exercise testing as a measure of exercise capacity",[9,21,25],[53],"CPET",{"type":30,"name":55,"description":56,"armGroupLabels":57,"otherNames":10},"Sputum analysis","Participants will provide a sputum sample that will be analysed for eosinophils",[9,21,25],{"type":30,"name":59,"description":60,"armGroupLabels":61,"otherNames":10},"Blood analysis","Participants will have their blood drawn and analysed for eosinophil count.",[9,21,25],{"type":6,"name":63,"description":64,"armGroupLabels":65,"otherNames":10},"Questionnaires","Participants will complete questionnaires to assess activity related dyspnea, respiratory symptoms and health status impairment and respiratory related quality of life.",[9,21,25],[67],{"name":68,"affiliation":69,"role":70},"Grace E Parraga","Western University - Robarts Research Institute","PRINCIPAL_INVESTIGATOR",[72,77],{"name":73,"role":74,"phone":75,"phoneExt":10,"email":76},"Grace E Parraga, PhD","CONTACT","519-931-5265","gparraga@robarts.ca",{"name":78,"role":74,"phone":79,"phoneExt":80,"email":81},"Angela Wilson, RRT","519-931-5777","24197","awilson@robarts.ca",[83],{"facility":84,"status":85,"city":86,"state":87,"zip":88,"country":89,"countryCode":90,"cosmosGeoPoint":91,"geoPoint":96,"contacts":97},"Robarts Research Institute; The University of Western Ontario; London Health Sciences Centre","RECRUITING","London","Ontario","N6A 5B7","Canada","CA",{"type":92,"coordinates":93},"Point",[94,95],-81.23304,42.98339,{"lat":95,"lon":94},[98],{"name":73,"role":74,"phone":75,"phoneExt":10,"email":99},"gparraga@uwo.ca",{"type":70,"investigatorFullName":101,"investigatorTitle":102,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Dr. Grace Parraga","PhD, Scientist. Robarts Research Institute",[104],{"name":105,"class":6},"London Health Sciences Centre","100409809","novel-pulmonary-imaging-of-lung-structure-and-function-in-e-cigarette-smokers-100409809",false,"NCT04616313","Novel Pulmonary Imaging of Lung Structure and Function in E-cigarette Smokers","Novel Pulmonary Imaging of Lung Structure and Function in Symptomatic and Asymptomatic E-cigarette Smokers","Inclusion Criteria:\n\n* Written informed consent must be directly obtained from legally competent participants before any study-related assessment is performed.\n* Male and female participant age ≥16 years.\n* Participant has recently started vaping, \\>1 and \\\u003C5 years weekly use.\n* 70 participants will be c-cigarette never users.\n* 70 participants will be former or current c-cigarette users.\n* 10 asymptomatic age and sex-matched healthy people who have never used e- or c-cigarettes will be controls.\n\nExclusion Criteria:\n\n* Participants with contraindications for undergoing an MRI such as participants with MRI-sensitive implants, tattoos with MRI-sensitive dye and severe claustrophobia.\n* Participant is, in the opinion of the investigator, mentally or legally incapacitated, preventing informed consent from being obtained, or cannot read or understand written material.\n* Participant unable to perform spirometry or plethysmography maneuvers.",true,"ALL","16 Years",{"count":117,"type":118},150,"ESTIMATED","OBSERVATIONAL","This is a longitudinal study of the long-term health impact of e-cigarette smoking on the lungs. Participants will be followed over a period of 5 years, and impacts of e-cigarette smoking on the lungs will be measured with magnetic resonance imaging (MRI) using hyperpolarized xenon-129 gas, pulmonary function tests, exercise capacity, computed tomography images and questionnaires.",[122],"E Cigarette Use",[124,125,126,127],"e-cigarette smoking","pulmonary function","Xenon-129","Magnetic Resonance Imaging","2025-08-08",{"date":130,"type":131},"2025-08-14","ACTUAL",{"date":133,"type":131},"2023-01-17",{"date":135,"type":118},"2027-12",{"name":5,"class":6},1]