[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100614532":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":11,"centralContacts":35,"locations":41,"responsibleParty":54,"collaborators":56,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":68,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":11,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":81,"overallStatus":85,"whyStopped":11,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Maastricht University Medical Center","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Plant-dominant proteins","EXPERIMENTAL",null,[13,14],"Dietary Supplement: Nutritionally complete tube feed providing a sole source of nutrition with a plant-dominant protein mix","Device: Neuromuscular Electrical Stimulation (NMES)",{"label":16,"type":17,"description":11,"interventionNames":18},"Animal-based proteins","ACTIVE_COMPARATOR",[19,14],"Dietary Supplement: Nutritionally complete tube feed providing a sole source of nutrition with an animal-based protein mix",[21,26,30],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":11},"DIETARY_SUPPLEMENT","Nutritionally complete tube feed providing a sole source of nutrition with a plant-dominant protein mix","Containing plant-based proteins.",[9],{"type":22,"name":27,"description":28,"armGroupLabels":29,"otherNames":11},"Nutritionally complete tube feed providing a sole source of nutrition with an animal-based protein mix","Containing animal-based proteins.",[16],{"type":31,"name":32,"description":33,"armGroupLabels":34,"otherNames":11},"DEVICE","Neuromuscular Electrical Stimulation (NMES)","The protocol will consist of a warm-up period (5 min), a stimulation period (30min), and a cooling-down period (5min).",[16,9],[36],{"name":37,"role":38,"phone":39,"phoneExt":11,"email":40},"Michèlle Hendriks","CONTACT","+31 43 388 1184","michelle.hendriks@maastrichtuniversity.nl",[42],{"facility":43,"status":11,"city":44,"state":11,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":11},"Maastricht University","Maastricht","6200 MD","Netherlands","NL",{"type":49,"coordinates":50},"Point",[51,52],5.68889,50.84833,{"lat":52,"lon":51},{"type":55,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR",[57],{"name":58,"class":59},"Danone Global Research & Innovation Center","INDUSTRY","100614532","nutritional-and-physical-intervention-during-bed-rest-100614532",false,"NCT07280819","Nutritional and Physical Intervention During Bed Rest","The Impact of Protein Source and Neuromuscular Electrical Stimulation on Muscle Protein Synthesis During Bed Rest","Bed-Plant","Inclusion Criteria:\n\n* Healthy (assessed based on routine medical questionnaire)\n* Male and female sexes\n* Aged between 18 and 35 years inclusive\n* BMI between 18.5 and 30.0 kg\u002Fm²\n\nExclusion Criteria:\n\n* Vegan diet\n* Allergies or intolerance to cow's milk products, fish, soy, and\u002For pea protein\n* Galactosemia\n* Smoking on a weekly basis (i.e., every week)\n* Diagnosed diabetes mellitus\n* Chronic corticosteroid use\n* Severe kidney and\u002For liver failure\n* Dialysis\n* Bleeding disorders, including anticoagulant and antiplatelet therapy\n* Currently pregnant",true,"ALL","18 Years","35 Years",{"count":73,"type":74},20,"ESTIMATED","INTERVENTIONAL",[77],"NA","Hospitalization often involves long periods of bed rest and reduced nutritional intake, which can lead to skeletal muscle loss and anabolic resistance. These effects slow recovery and increase the risk of complications, long-term disability and healthcare costs. Animal-based proteins are effective at stimulating muscle protein synthesis (MPS) because they contain all essential amino acids and have high bioavailability, but they are less sustainable. Plant-based proteins are more environmentally friendly but may be less effective for MPS due to lower essential amino acid content and lower digestibility. Combining different plant proteins may improve their quality, yet their impact during bed rest is still unclear. Neuromuscular electrical stimulation (NMES) may help counteract anabolic resistance by mimicking exercise, but its long-term effects in bedridden individuals are not well studied.\n\nThis prospective, randomized, controlled trial aims to assess the effects of a nutritional intervention (plant-dominant versus dairy-based protein) and a physical stimulus (NMES versus non-NMES) on MPS during 4 days of bed rest in healthy young adults.",[80],"Muscle Protein Synthetic Response to Protein",[82,83,84],"muscle biopsy","tracer methodology","NMES","NOT_YET_RECRUITING","2025-12-10",{"date":88,"type":89},"2025-12-12","ACTUAL",{"date":91,"type":74},"2026-01",{"date":93,"type":74},"2029-01",{"name":5,"class":6},1]