[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100601225":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":7,"centralContacts":14,"locations":20,"responsibleParty":36,"collaborators":7,"id":40,"slug":41,"hasResults":42,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":42,"sex":48,"minAge":49,"maxAge":7,"enrollmentInfo":50,"targetDuration":7,"studyType":53,"phases":7,"briefSummary":54,"conditions":55,"keywords":7,"overallStatus":23,"whyStopped":7,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":67},{"fullName":5,"class":6},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","OTHER",null,[9,12],{"type":6,"name":10,"description":11,"armGroupLabels":7,"otherNames":7},"Noradrenalin","After inclusion, patients will be tested for fluid responsiveness. Pulse pressure variation (PPV) will be evaluated.\n\nIn case of PPV\\> 13% a fluid bolus of 500 mL of Lactated Ringer's will be administered in 10 minutes.\n\nIf PPV\\\u003C 8% Norepinephrine will be administered or increased. If PPV is in the gray zone, a PLRT will be performed and if CO increases more than 10% a fluid bolus will be prescribed, otherwise norepinephrine increased.",{"type":6,"name":13,"description":11,"armGroupLabels":7,"otherNames":7},"Fluid bolus",[15],{"name":16,"role":17,"phone":18,"phoneExt":7,"email":19},"Antonio M Dell'Anna","CONTACT","+39 0630154490","antoniomaria.dellanna@policlinicogemelli.it",[21],{"facility":22,"status":23,"city":24,"state":7,"zip":25,"country":26,"countryCode":27,"cosmosGeoPoint":28,"geoPoint":33,"contacts":34},"Policlinico Universitario Fondazione Agostino Gemelli IRCCS","RECRUITING","Roma","00168","Italy","IT",{"type":29,"coordinates":30},"Point",[31,32],11.10642,44.99364,{"lat":32,"lon":31},[35],{"name":16,"role":17,"phone":18,"phoneExt":7,"email":19},{"type":37,"investigatorFullName":38,"investigatorTitle":39,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"PRINCIPAL_INVESTIGATOR","Antonio Maria Dell'Anna","Doctor, MD","100601225","o2-consumption-and-co2-production-after-hemodynamic-optimization-in-shock-100601225",false,"NCT07107724","O2 Consumption And CO2 Production After Hemodynamic Optimization In Shock","Oxygen Consumption And Carbon Dioxide Production Following Hemodynamic Optimization In Shock: The OxyCarDio Study","OxyCarDio","Inclusion Criteria:\n\nHypotension (MAP\\\u003C 65mmHg or sudden drop in MAP \\> 15 mmHg) and one of the following conditions:\n\n* Heart rate \\> 120 bpm\n* Urinary output \\\u003C 0.5 ml\u002Fkg\u002Fh for at least two hours\n* Lactate \\> 2 mmol\u002FL\n\nExclusion Criteria:\n\n* Urgent need for surgery\n* Urgent need for veno-arterial ECMO or severe hemodynamic instability\n* Consistent risk of imminent death\n* Severe ARDS or severe respiratory failure (p\u002FF \\\u003C 100 mmHg) and\u002For FiO2\\>0.8\n* Severe heart failure (NYHA 4 and\u002For EF\\\u003C25%)\n* Need for intermittent or continuous renal replacement therapy (IRRT or CRRT)\n* Anemia defined as Hb\\\u003C8 g\u002FdL\n* VO2 variability \\\u003C 5% throughout ten minutes of stabilization before procedure start\n* Intraabdominal hypertension, defined as intraabdominal pressure \\> 18 mmHg\n* Pregnancy\n* Withdrawal or refuse of informed consent\n* Terminal disease\n* Do-not-resuscitate order.","ALL","18 Years",{"count":51,"type":52},36,"ESTIMATED","OBSERVATIONAL","The goal of this prospective observational study is to analyse change in VO2 and VCO2 measured via a dedicated ventilator after hemodynamic optimization maneuvers in adult patients admitted to the ICU with any sign of shock.\n\nThe main questions it aims to answer are:\n\n1. Do common maneuvers for hemodynamic optimization (fluid bolus and\u002For vasopressor administration) have any impact on tissue perfusion in terms of oxygen consumption (VO2) and carbon dioxide production (VCO2) measured by a dedicated ventilator?\n2. Are the values measured by exhaled gas comparable to those calculated by the measurement of dissolved veno-arterial gas?\n\nParticipants enrolled in the study will receive advanced hemodynamic monitoring with MostCare Up (Vygon ®) and their hemodynamic instability will be managed according to most recent guidelines and based on clinical decision of treating physicians.",[56,57],"Hemodynamic Instability","Oxygen Consumption (V̇O2)","2025-07-30",{"date":60,"type":61},"2025-08-06","ACTUAL",{"date":63,"type":61},"2025-07-29",{"date":65,"type":52},"2027-12",{"name":5,"class":6},1]