[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100634444":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":17,"locations":23,"responsibleParty":42,"collaborators":10,"id":44,"slug":45,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":53,"minAge":54,"maxAge":10,"enrollmentInfo":55,"targetDuration":58,"studyType":59,"phases":10,"briefSummary":60,"conditions":61,"keywords":65,"overallStatus":26,"whyStopped":10,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"Zuyderland Medisch Centrum","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Patients with obesity grade 2 or higher presenting at the Dutch obesity clinic requesting MBS.",null,"Our study population consists of patients presenting at the DOC South requesting Metabolic bariatric surgery (MBS). 10-15 new patients present themselves weekly at the DOC South, from which study participants can be recruited. Our population is 35 years or older and has no previous history of a reduced ejection fraction, severe cardiac valve defects of severe congenital cardiac defects. Our population does not have a previous history of metabolic bariatric surgery.",[13],{"name":14,"affiliation":15,"role":16},"Sandra van Wijk, Dr.","Zuyderland Medical Center","PRINCIPAL_INVESTIGATOR",[18],{"name":19,"role":20,"phone":21,"phoneExt":10,"email":22},"Lukas Peeters, Master of Science in Medicine","CONTACT","+32479092470","luka.peeters@zuyderland.nl",[24],{"facility":25,"status":26,"city":27,"state":28,"zip":29,"country":30,"countryCode":31,"cosmosGeoPoint":32,"geoPoint":37,"contacts":38},"Zuyderland Medisch Centrum Heerlen","RECRUITING","Heerlen","Limburg","6419PC","Netherlands","NL",{"type":33,"coordinates":34},"Point",[35,36],5.98154,50.88365,{"lat":36,"lon":35},[39,40],{"name":19,"role":20,"phone":21,"phoneExt":10,"email":22},{"name":19,"role":41,"phone":10,"phoneExt":10,"email":10},"SUB_INVESTIGATOR",{"type":43,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100634444","obese-hfpef-towards-preventing-obesity-related-hfpef-100634444",false,"NCT07539766","OBESE-HFpEF: Towards Preventing Obesity Related HFpEF","OBESE-HFpEF: Prevalence and Mediators of Heart Failure (Preserved Ejection Fraction) in the Dutch Obesity Clinic South - Towards Preventing Obesity Related HFpEF''","OBESE-HFpEF","Inclusion Criteria:\n\n* Age ≥ 35 years\n* Eligible for surgical treatment for obesity, according to the Dutch guideline, i.e. a BMI ≥ 40 kg\u002Fm2 or a BMI ≥ 35 kg\u002Fm2 with one or more comorbidities associated with obesity. (23)\n\nExclusion Criteria:\n\n* Inability to provide informed consent.\n* A BMI \\>60 kg\u002Fm2\n* Inability of undergoing metabolic bariatric surgery safely.\n* Inability to undergo the study measurement\u002Ftests.\n* Not proficient in the Dutch language\n* A medical history of a reduced LVEF at any time, history of severe cardiac valve defects or severe congenital cardiac defects.\n* A medical history of previous metabolic bariatric surgery.",true,"ALL","35 Years",{"count":56,"type":57},250,"ESTIMATED","2 Years","OBSERVATIONAL","Obesity, severe overweight, is a growing problem worldwide and increases the risk of heart failure, especially a type called heart failure with preserved ejection fraction (HFpEF).\n\nIn HFpEF, the heart becomes stiffer. This makes it harder for the heart to fill with blood, which can lead to shortness of breath during physical activity.\n\nIn the Netherlands, 15% of the population has obesity. In South Limburg, this is even higher at 19%. Among people with HFpEF, obesity is much more common: about 50% of these patients have obesity.\n\nLife expectancy in people with HFpEF is poor, and current treatment mainly focuses on reducing symptoms. Early recognition and treatment of risk factors, such as obesity, are therefore very important.\n\nThis study includes about 250 people with obesity. Using a heart ultrasound and tests of blood and fat tissue, we will look for early signs of HFpEF and study the effects of weight loss. The measurements will be repeated after 1 and 2 years.\n\nThe goal of this study is to better understand how obesity contributes to HFpEF and how weight loss affects the heart. This research may help improve future treatments for patients with HFpEF.",[62,63,64],"Heart Failure and Preserved Ejection Fraction","Obesity (Disorder)","Heart Failure",[66,67,68,69],"Obesity","Heart Failure with preserved ejection fraction","Metabolic Bariatric Surgery","Prospective","2026-04-13",{"date":72,"type":73},"2026-04-20","ACTUAL",{"date":75,"type":73},"2025-01-01",{"date":77,"type":57},"2029-01-01",{"name":5,"class":6},1]