[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100568743":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":40,"centralContacts":45,"locations":54,"responsibleParty":69,"collaborators":31,"id":73,"slug":74,"hasResults":75,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":75,"sex":81,"minAge":82,"maxAge":83,"enrollmentInfo":84,"targetDuration":31,"studyType":87,"phases":88,"briefSummary":90,"conditions":91,"keywords":94,"overallStatus":96,"whyStopped":31,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"Sixth Affiliated Hospital, Sun Yat-sen University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Group O","EXPERIMENTAL","Titrated administration of propofol to an OAA\u002FS score of 1 as the endpoint.",[13],"Procedure: Titrated administration of propofol to an OAA\u002FS score of 1 as the endpoint",{"label":15,"type":10,"description":16,"interventionNames":17},"Group T","Titrated administration of propofol to an OAA\u002FS score of 2 as the endpoint.",[18],"Procedure: Titrated administration of propofol to an OAA\u002FS score of 2 as the endpoint",{"label":20,"type":21,"description":22,"interventionNames":23},"Group B","ACTIVE_COMPARATOR","Titrated administration of propofol to a BIS value ≤ 60 as the endpoint.",[24],"Procedure: Titrated administration of propofol to a BIS value ≤ 60 as the endpoint",[26,32,36],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"PROCEDURE","Titrated administration of propofol to an OAA\u002FS score of 1 as the endpoint","Propofol is titrated at a rate of 0.5 mg\u002Fkg\u002Fmin to achieve an OAA\u002FS score of 1, followed by a maintenance dose of 2-4 mg\u002Fkg\u002Fh, concurrently with remifentanil 2 ug\u002Fkg and rocuronium 0.6 mg\u002Fkg for anesthesia induction.",[9],null,{"type":27,"name":33,"description":34,"armGroupLabels":35,"otherNames":31},"Titrated administration of propofol to an OAA\u002FS score of 2 as the endpoint","Propofol is titrated at a rate of 0.5 mg\u002Fkg\u002Fmin to achieve an OAA\u002FS score of 2, followed by a maintenance dose of 2-4 mg\u002Fkg\u002Fh, concurrently with remifentanil 2 ug\u002Fkg and rocuronium 0.6 mg\u002Fkg for anesthesia induction.",[15],{"type":27,"name":37,"description":38,"armGroupLabels":39,"otherNames":31},"Titrated administration of propofol to a BIS value ≤ 60 as the endpoint","Propofol is titrated at a rate of 0.5 mg\u002Fkg\u002Fmin to achieve a BIS value ≤ 60, followed by a maintenance dose of 2-4 mg\u002Fkg\u002Fh, concurrently with remifentanil 2 ug\u002Fkg and rocuronium 0.6 mg\u002Fkg for anesthesia induction.",[20],[41],{"name":42,"affiliation":43,"role":44},"SanQing Jin, MD","The Sixth Affiliated Hospital, Sun Yat-sen University","PRINCIPAL_INVESTIGATOR",[46,50],{"name":42,"role":47,"phone":48,"phoneExt":31,"email":49},"CONTACT","0086-13719366863","jinsq@mail.sysu.edu.cn",{"name":51,"role":47,"phone":52,"phoneExt":31,"email":53},"LiHong Chen, MD","0086-13760779697","chenlihn@mail.sysu.edu.cn",[55],{"facility":56,"status":31,"city":57,"state":58,"zip":31,"country":59,"countryCode":60,"cosmosGeoPoint":61,"geoPoint":66,"contacts":67},"the Sixth Affiliated Hospital, Sun Yat-sen University","Guangzhou","Guangdong","China","CN",{"type":62,"coordinates":63},"Point",[64,65],113.25,23.11667,{"lat":65,"lon":64},[68],{"name":42,"role":47,"phone":48,"phoneExt":31,"email":49},{"type":70,"investigatorFullName":71,"investigatorTitle":72,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"SPONSOR_INVESTIGATOR","SanQing Jin","professor","100568743","observation-on-administration-of-propofol-at-different-titration-endpoints-100568743",false,"NCT06685198","Observation on Administration of Propofol at Different Titration Endpoints","The Impact of Different Titration Endpoints of Propofol on Hemodynamics and Stress During the Induction Phase of General Anesthesia","OAPDTE","Inclusion Criteria:\n\n1. Age 18-60 years.\n2. Elective surgery with planned endotracheal intubation under general anesthesia.\n3. ASA classification of I or II,with heart function classified as 1 or 2.\n4. Body Mass Index (BMI) 18-30 kg\u002Fm².\n\nExclusion Criteria:\n\n1. Severe cardiac, pulmonary, hepatic, or renal diseases (heart function classification greater than 3 \u002F respiratory failure \u002F liver failure \u002F renal failure).\n2. Malignant arrhythmias: atrial flutter, atrial fibrillation, atrioventricular block, frequent ventricular premature beats, multifocal ventricular premature beats, ventricular premature beats R on T, ventricular flutter, and ventricular fibrillation.\n3. Expected difficulty with intubation, hypoalbuminemia, hypertension, or diabetes mellitus.\n4. Patients with a high risk of aspiration due to a full stomach, gastrointestinal obstruction, or pregnancy.\n5. Patients with schizophrenia, epilepsy, Parkinson's disease, intellectual disabilities, etc.\n6. Alcohol abusers or those who have been using sedatives or analgesics long-term.\n7. Allergic to propofol or its emulsion.\n8. Currently participating in a clinical trial that conflicts with this study.","ALL","18 Years","60 Years",{"count":85,"type":86},258,"ESTIMATED","INTERVENTIONAL",[89],"NA","Propofol has a rapid onset and short duration of action, making it widely used for induction of general anesthesia. However, its prominent drawback is circulatory depression. Our research team previously proposed an individualized dosing method for the titration of propofol. We then compared the effects of different titration rates of propofol on hemodynamics and stress during general anesthesia induction. It was found that the incidence of hypotension during the induction period was lower in the 0.5 mg\u002Fkg\u002Fmin group, with lower stress levels and faster postoperative recovery. However, this group still had a 25.3% incidence of hypotension. Therefore, we plan to further study the differences in hemodynamics, depth of anesthesia, stress response, and postoperative recovery in three groups of patients induced with a constant infusion rate of propofol at 0.5 mg\u002Fkg\u002Fmin titrated to an OAA\u002FS score of 1, an OAA\u002FS score of 2, and BIS ≤ 60, combined with remifentanil 2 μg\u002Fkg. This study aims to explore the appropriate propofol titration endpoint during general anesthesia induction to maintain stable perioperative haemodynamics and achieve rapid postoperative recovery.",[92,93],"Anesthesia, General","Hemodynamics",[95],"titration of propofol","NOT_YET_RECRUITING","2024-12-01",{"date":99,"type":100},"2024-12-04","ACTUAL",{"date":102,"type":86},"2025-02-20",{"date":104,"type":86},"2025-08-20",{"name":71,"class":6},1]