[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100628780":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":7,"centralContacts":13,"locations":7,"responsibleParty":19,"collaborators":7,"id":23,"slug":24,"hasResults":25,"nctId":26,"briefTitle":27,"officialTitle":28,"acronym":29,"eligibilityCriteria":30,"healthyVolunteers":31,"sex":32,"minAge":33,"maxAge":34,"enrollmentInfo":35,"targetDuration":7,"studyType":38,"phases":7,"briefSummary":39,"conditions":40,"keywords":7,"overallStatus":43,"whyStopped":7,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":50,"leadSponsor":52,"locationsCount":7},{"fullName":5,"class":6},"Cairo University","OTHER",null,[9],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":7},"DIAGNOSTIC_TEST","IL-8 and Presepsin levels in the pulpal blood.","Interleukin-8 (IL-8): This is a pro-inflammatory chemokine. The outcome will be the quantified level of IL-8, likely measured in picograms per milliliter (pg\u002FmL) , obtained from pulp tissue samples.\n\nPresepsin: This is likely a precursor to pepsinogen, which can be involved in inflammatory processes. The outcome will be the quantified level of Presepsin, likely measured in similar units as IL-8, obtained from pulp tissue samples.",[14],{"name":15,"role":16,"phone":17,"phoneExt":7,"email":18},"Sarah Shokry Ibrahim","CONTACT","00201091227355","sara.shokry@dentistry.cu.edu.eg",{"type":20,"investigatorFullName":21,"investigatorTitle":22,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"PRINCIPAL_INVESTIGATOR","Sarah Shokry Ibrahim Mohammed","PhD candidate","100628780","observational-cross-sectional-study-aiming-to-determine-the-correlation-between-pulpal-status-and-il-8-and-presepsin-levels-in-the-pulpal-blood-100628780",false,"NCT07466095","Observational Cross-sectional Study Aiming to Determine the Correlation Between Pulpal Status and IL-8 and Presepsin Levels in the Pulpal Blood.","Assessing the Differential Performance of the Inflammatory Biomarkers Interleukin-8 and Presepsin in Patients Exhibiting Clinical Symptoms Suggestive of Reversible and Irreversible Pulpitis: A Preliminary Cross -Sectional Study","Cross-section","Inclusion Criteria:\n\n* Male and female patients. Age between 14 years and 50 years . Diagnosis established in accordance with the American Association of Endodontists (AAE) (2013) for normal pulp, reversible pulpitis, or symptomatic irreversible pulpitis. Participants will be asked if they wish to be included in the study (implying informed consent).\n\nNormal pulp Sound, unrestored non-carious vital teeth will be included. The teeth with healthy pulp. The teeth indicated for orthodontic extraction or elective root canal treatment before prosthodontic intervention.\n\nThere with no clinical signs or symptoms of pulpitis. There with no history of pain. The response to the cold test within normal limits. No sensitivity to percussion. No periodontal ligament space widening (Periapical Index (PAI) = 1). Teeth with Reversible Pulpitis \\[RP\\] Medically healthy patients will be included.\n\nPatients with extremely deep carious lesion (according to Bjørndal, 2017) One or more of the following signs and symptoms present:\n\nClinical symptoms of minor intensity. Slightly exaggerated reaction to cold or sweet stimuli. No history of spontaneous pain. Response to the cold test within normal limits. No sensitivity to chewing. No sensitivity to percussion. No widening of the periodontal ligament space (Periapical Index (PAI) = 1). Teeth with Irreversible Pulpitis \\[IRP\\] Medically healthy patients will be included. Patients with extremely deep carious lesion\n\nOne or more of the following signs and symptoms were present:\n\nHistory of continuous moderate or severe pain. Either provoked or spontaneous lingering pain initiated by provocation (cold test).\n\nTenderness to chewing or percussion. No widening of the periodontal ligament space (Periapical Index (PAI) = 1) (Orstavik,1988)\n\nExclusion Criteria:\n\n* Absence of a response to pulp sensibility tests. Non-restorable teeth. Periodontal involvement. Presence of a sinus tract. Presence of periapical pathology on radiograph. Presence of resorption (external or internal). Cracked teeth. Immature teeth with an open apex. Presence of any systemic disease. Pregnant females. History of intake of Non-Steroidal Anti-inflammatory Drugs (NSAIDs) or antibiotics within the last 1 week.\n\nPatients who needed prophylactic antibiotics. No pulp exposure after complete caries removal. Inadequate blood volume collection after pulpal exposure.",true,"ALL","14 Years","50 Years",{"count":36,"type":37},50,"ESTIMATED","OBSERVATIONAL","Observational cross-sectional study aims to determine the correlation between pulpal status and IL-8 and Presepsin levels in the pulpal blood.",[41,42],"Pulpitis - Irreversible","Pulpitis - Reversible","NOT_YET_RECRUITING","2026-03-08",{"date":46,"type":47},"2026-03-12","ACTUAL",{"date":49,"type":37},"2026-11-01",{"date":51,"type":37},"2027-12-01",{"name":5,"class":6}]