[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100522178":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":7,"centralContacts":15,"locations":24,"responsibleParty":50,"collaborators":7,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":7,"eligibilityCriteria":57,"healthyVolunteers":54,"sex":58,"minAge":59,"maxAge":7,"enrollmentInfo":60,"targetDuration":63,"studyType":64,"phases":7,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":75,"whyStopped":7,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"GrandPharma (China) Co., Ltd.","INDUSTRY",null,[9],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":13},"DEVICE","Resin microspheres containing yttrium-90 (Y-90)","SIR-Spheres Y-90 resin microspheres are permanent implant and for single use only",[14],"SIR-Spheres® Y-90",[16,21],{"name":17,"role":18,"phone":19,"phoneExt":7,"email":20},"Hui Wen, B.S.","CONTACT","027-84399665","huiwen@grandpharma.cn",{"name":22,"role":18,"phone":19,"phoneExt":7,"email":23},"xixi Hu, MS","huxx@grandpharma.cn",[25],{"facility":26,"status":7,"city":27,"state":28,"zip":29,"country":30,"countryCode":31,"cosmosGeoPoint":32,"geoPoint":37,"contacts":38},"Sir Run Run Shaw Hospital (SRRSH), affiliated with the Zhejiang University School of Medicine","Hangzhou","Zhejiang","310002","China","CN",{"type":33,"coordinates":34},"Point",[35,36],120.16142,30.29365,{"lat":36,"lon":35},[39,43,46,48],{"name":40,"role":18,"phone":41,"phoneExt":7,"email":42},"hongming Pan, PhD","0571-86006922","shonco@sina.cn",{"name":44,"role":18,"phone":41,"phoneExt":7,"email":45},"weidong Han, PhD","hanwd@zju.edu.cn",{"name":40,"role":47,"phone":7,"phoneExt":7,"email":7},"PRINCIPAL_INVESTIGATOR",{"name":44,"role":49,"phone":7,"phoneExt":7,"email":7},"SUB_INVESTIGATOR",{"type":51,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100522178","observational-study-for-sir-spheres-therapy-for-the-treatment-of-unresectable-metastatic-liver-tumors-from-primary-colorectal-cancer-100522178",false,"NCT06079242","Observational Study for SIR-Spheres Therapy for the Treatment of Unresectable Metastatic Liver Tumors From Primary Colorectal Cancer","Inclusion Criteria:\n\n1. Obtained informed consent for patients to be follow-up prospectively\n2. Age≥18 years old\n3. Histologically or pathologically confirmed diagnosis of unresectable metastatic liver tumors from primary colorectal cancer and failed standard of care\n4. Received SIR-Spheres®\n\nExclusion Criteria:\n\n1. Special contraindications from package insert, which includes\n\n   1. Markedly abnormal liver function tests, such as total bilirubin \\> 2.0 mg\u002FdL or albumin \\\u003C3.0 g\u002FdL\n   2. Portal vein thrombosis in the main trunk\n   3. Disseminated extrahepatic disease\n   4. Previous external beam radiation therapy to the liver\n2. Women are lactating or pregnant during the study or plan to be pregnant during the study\n3. Patients with mental illness or cognitive impairment\n4. Per investigator, patients are non-adherent or reluctant to be followed up","ALL","18 Years",{"count":61,"type":62},200,"ESTIMATED","24 Months","OBSERVATIONAL","This real-world study tries to collect data reflecting routine use of SIR-Spheres in patients diagnosed with unresectable liver metastases from Metastatic Liver Tumors From Primary Colorectal Cancer (mCRC) refractory to or intolerant to chemotherapy, in order to assess clinical response in a real-world setting and further validate the safe and appropriate use of SIR-Spheres in China.",[67],"Colorectal Neoplasms",[69,70,71,72,73,74],"Metastatic Colorectal Cancer","90Y","Liver Metastases","SIRT","Radioembolization","SIR-Spheres Microspheres","NOT_YET_RECRUITING","2023-10-11",{"date":78,"type":79},"2023-10-13","ACTUAL",{"date":81,"type":62},"2023-10-15",{"date":83,"type":62},"2027-04-01",{"name":5,"class":6},1]