[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100621751":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":25,"locations":34,"responsibleParty":54,"collaborators":19,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":60,"acronym":19,"eligibilityCriteria":61,"healthyVolunteers":58,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":19,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":79,"overallStatus":37,"whyStopped":19,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"National Institutes of Health Clinical Center (CC)","NIH",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"1\u002FSmartMatch testing","OTHER","Turnaround time for SmartMatch platform implementation and molecular profiling of recurrent CNS tumors",[13],"Other: Tumor sample collection",[15],{"type":10,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"Tumor sample collection","Fresh tumor samples will be collected for the study only if available following a planned biopsy or resection performed at NIH.",[9],null,[21],{"name":22,"affiliation":23,"role":24},"Jing Wu, M.D.","National Cancer Institute (NCI)","PRINCIPAL_INVESTIGATOR",[26,31],{"name":27,"role":28,"phone":29,"phoneExt":19,"email":30},"Christine T McGowan","CONTACT","(240) 858-7330","christine.mcgowan@nih.gov",{"name":22,"role":28,"phone":32,"phoneExt":19,"email":33},"(240) 760-6036","jing.wu3@nih.gov",[35],{"facility":36,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"National Institutes of Health Clinical Center","RECRUITING","Bethesda","Maryland","20892","United States","US",{"type":44,"coordinates":45},"Point",[46,47],-77.10026,38.98067,{"lat":47,"lon":46},[50],{"name":51,"role":28,"phone":52,"phoneExt":19,"email":53},"National Cancer Institute Referral Office","888-624-1937","ncimo_referrals@mail.nih.gov",{"type":55,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR","100621751","observational-study-of-responses-to-treatments-in-advanced-central-nervous-system-cns-tumors-100621751",false,"NCT07374692","Observational Study of Responses to Treatments in Advanced Central Nervous System (CNS) Tumors","* INCLUSION CRITERIA\n* Participants must have advanced CNS tumors confirmed by a documented pathology report, including:\n\n  * recurrent isocitrate dehydrogenase (IDH)-wild-type high-grade glioma\n  * recurrent IDH-mutant gliomas\n  * other recurrent CNS tumors\n* Participants must have been scheduled for a brain tumor biopsy or resection. Note: Scheduled brain tumor biopsy or resection must be at least 6 months after any previous radiation therapy, if applicable. All procedures are planned to take place at NIH.\n* Age \\>= 15 years.\n* Ability of participant, parent\u002Fguardian, or Legally Authorized Representative (LAR) to understand and sign a written informed consent document.\n\nEXCLUSION CRITERIA\n\nNone.","ALL","15 Years","120 Years",{"count":66,"type":67},80,"ESTIMATED","INTERVENTIONAL",[70],"NA","Background:\n\nPrimary central nervous system (CNS) tumors grow in the brain and spinal cord. These tumors are rare, but they are difficult to treat and often fatal. SmartMatch is a new technology that tries to help find the best medicines for the particular tumor by testing how small pieces of surgically removed tumor tissue react to different drugs. The study team wants to see if SmartMatch can complete the analysis and generate a report within 21 days from the time of the surgery.\n\nObjective:\n\nTo better understand CNS tumors so doctors can find better ways to treat them in the future.\n\nEligibility:\n\nPeople aged 15 years and older with recurrent CNS tumors. Patient must already be scheduled for a surgery for the tumor at the NIH.\n\nDesign:\n\nThe study team will collect a small amount of tumor samples during the planned surgery. They may also use tumor samples from previous procedures. No new or additional procedures will be done for the purpose of this study.\n\nThe tumor samples will be sent to a lab for SmartMatch analysis. Once completed, the results will be shared with the patient and his\u002Fher local doctor. Together they can decide whether to incorporate the results into the treatment plan. It is important to know that the results may or may not be helpful.\n\nThere will only be one blood test for research. Blood and tissue samples collected may be used for additional analysis. Tumor tissue may be used to grow additional samples for further study. Participants will receive a pathology diagnosis and mutation profile generated by pathologists who specialize in CNS tumors.\n\nThe study team will seek updates on participant's health approximately every 6 months for 3 years. Tumor samples may also be collected from any additional surgery done at NIH during this time....",[73,74,75,76,77,78],"Recurrent CNS Tumors","Brain Cancer","Gliomas","IDH-wildtype Gliomas","IDH-mutant Gliomas","Rare CNS Tumor",[80,81,82,83,75,84],"CNS Tumor","Brain Tumor","Rare Tumor","SmartMatch","Drug Screen","2026-05-21",{"date":87,"type":88},"2026-05-22","ACTUAL",{"date":90,"type":88},"2026-02-04",{"date":92,"type":67},"2030-12-30",{"name":23,"class":6},1]