[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100599167":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":23,"centralContacts":28,"locations":38,"responsibleParty":50,"collaborators":10,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":54,"sex":60,"minAge":61,"maxAge":10,"enrollmentInfo":62,"targetDuration":10,"studyType":65,"phases":10,"briefSummary":66,"conditions":67,"keywords":10,"overallStatus":40,"whyStopped":10,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"Gruppo Italiano Malattie EMatologiche dell'Adulto","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"APL-like",null,"NPM1 AML patients identified as APL-like cohort",[13],"Other: observation of incidence of early vascular events",{"label":15,"type":10,"description":16,"interventionNames":17},"Non APL-like","NPM1 AML patients identified as no APL-like cohort",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"observation of incidence of early vascular events","observation of difference incidence of early vascular events in the two cohorts",[9,15],[24],{"name":25,"affiliation":26,"role":27},"Francesco Mannelli","SOD Ematologia, Università di Firenze, AOU Careggi","PRINCIPAL_INVESTIGATOR",[29,34],{"name":30,"role":31,"phone":32,"phoneExt":10,"email":33},"Paola Fazi","CONTACT","0670390528","p.fazi@gimema.it",{"name":35,"role":31,"phone":36,"phoneExt":10,"email":37},"Enrico Crea","0670390514","e.crea@gimema.it",[39],{"facility":26,"status":40,"city":41,"state":10,"zip":10,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":10},"RECRUITING","Florence","Italy","IT",{"type":45,"coordinates":46},"Point",[47,48],11.24626,43.77925,{"lat":48,"lon":47},{"type":51,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100599167","observational-study-on-apl-like-acute-myeloid-leukemia-distinct-phenotype-and-early-vascular-complications-100599167",false,"NCT07080970","Observational Study on APL-like aCute Myeloid Leukemia: disTInct Phenotype and Early VAscular complicaTions","Observational Study on APL-like Subset Within NPM1-mutated Acute Myeloid Leukemia: a Distinct Phenotypic Signature Correlating With Early-onset Vascular Complications. ACTIVATE (APL-like aCute Myeloid Leukemia: disTInct Phenotype and Early VAscular complicaTions)","ACTIVATE","Inclusion Criteria:\n\n* Patients with de novo AML, untreated, newly diagnosed, according to WHO\u002FICC 2022 criteria from January 2015 onwards.\n* Presence of NPM1 mutation.\n* Availability of immunophenotypic characterization at diagnosis\n* Age \\>= 18 years\n* Signed written informed consent according to ICH\u002FEU\u002FGCP and national local laws (if applicable)\n\nExclusion Criteria:\n\n* No specific exclusion criteria are provided once eligibility criteria are met.","ALL","18 Years",{"count":63,"type":64},220,"ESTIMATED","OBSERVATIONAL","This is a multicenter observational study with a retrospective and a prospective cohort investigating clinically and biologically the APL-like subset as a potential predictor of coagulopathy and susceptibility to early vascular events.",[68,69],"Acute Myeloid Leukemia","NPM1 Mutation","2026-06-17",{"date":72,"type":73},"2026-06-22","ACTUAL",{"date":75,"type":64},"2026-07",{"date":77,"type":64},"2028-11",{"name":5,"class":6},1]