[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100605311":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":12,"centralContacts":28,"locations":34,"responsibleParty":51,"collaborators":54,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":59,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":12,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":12,"overallStatus":37,"whyStopped":12,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"St. James's Hospital, Ireland","OTHER",[8,13,16],{"label":9,"type":10,"description":11,"interventionNames":12},"Asthma - no sleep apnoea","NO_INTERVENTION","This the group of asthma patients without sleep apnoea",null,{"label":14,"type":10,"description":15,"interventionNames":12},"Asthma - sleep apnoea, no treatment","This the group of asthma patients with sleep apnoea (as defined as AHI ≥10 events per hour recorded) who have been randomized to the no treatment arm",{"label":17,"type":18,"description":19,"interventionNames":20},"Asthma - sleep apnoea, treatment","EXPERIMENTAL","This the group of asthma patients with sleep apnoea (as defined as AHI ≥10 events per hour recorded) who have been randomized to the treatment arm. They will receive CPAP therapy as treatment for sleep apnoea, while monitoring their asthma control measures and airflow variability.",[21],"Device: Continuous positive airway pressure (CPAP)",[23],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":12},"DEVICE","Continuous positive airway pressure (CPAP)","Continuous positive airway pressure - device to be used at night in the treatment of sleep apnoea",[17],[29],{"name":30,"role":31,"phone":32,"phoneExt":12,"email":33},"Laura Piggott, BM BS BSc MSc","CONTACT","+353876801786","laurampiggott@gmail.com",[35],{"facility":36,"status":37,"city":38,"state":38,"zip":12,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"St. James's Hospital","RECRUITING","Dublin","Ireland","IE",{"type":42,"coordinates":43},"Point",[44,45],-6.24889,53.33306,{"lat":45,"lon":44},[48],{"name":49,"role":31,"phone":50,"phoneExt":12,"email":33},"Laura Piggott","0876801786",{"type":52,"investigatorFullName":49,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":12,"oldOrganization":12},"PRINCIPAL_INVESTIGATOR","Principal Investigator",[55],{"name":56,"class":6},"Tallaght University Hospital","100605311","obstructive-sleep-apnoea-and-difficult-asthma-osada-100605311",false,"NCT07160868","Obstructive Sleep Apnoea and Difficult Asthma (OSADA)","Open-label Randomized Controlled Trial Investigating the Relationship Between Obstructive Sleep Apnoea and Difficult Asthma","OSADA","Inclusion Criteria:\n\n* Patients must have a clinical diagnosis of asthma with supportive objective diagnostics including but not limited to, variable airflow obstruction, bronchial-hyper responsiveness and demonstrable eosinophilic inflammation via fractional exhaled nitric oxide or peripheral eosinophilia\n* Patients receiving step 4 or step 5 of 'The Global Initiative for Asthma' (GINA) treatment guidelines will be selected\n* Between the ages of 18 to 90 years of age\n\nExclusion Criteria:\n\n* Patients with previous sleep study investigations\n* Excessive daytime sleepiness; ESS \\>17\n* Previous diagnosis of a sleep disorder\n* Resting hypoxaemia or need for long-term oxygen therapy\n* Inability to provide informed consent","ALL","18 Years","90 Years",{"count":69,"type":70},80,"ESTIMATED","INTERVENTIONAL",[73],"NA","The OSADA (Obstructive Sleep Apnoea in Difficult Asthma) trial is an open-label, randomized control trial investigating the impact of diagnosing and treating obstructive sleep apnoea (OSA) on a asthma control in patients with difficult-to-control asthma.\n\nParticipants will undergo home-based sleep studies to assess for OSA and are then allocated to one of three arms: 1) Patients with OSA treated with CPAP (intervention group), 2) Patients with OSA not treated for OSA (control group) and 3) Patients without OSA (reference group).\n\nThe primary objective is to evaluate whether treating OSA improves asthma control, symptom burden, and quality of life compared to untreated OSA and to patients without OSA. Secondary outcomes include exacerbation rates, sleep quality, and healthcare utilization.\n\nThis trial aims to clarify the contribution of OSA to poor asthma control and the potential benefits of integrated sleep and respiratory care in this complex population.",[76,77,78],"Asthma (Diagnosis)","OSA - Obstructive Sleep Apnea","CPAP Treatment","2026-05-20",{"date":81,"type":82},"2026-05-26","ACTUAL",{"date":84,"type":82},"2025-09-01",{"date":86,"type":70},"2026-05-22",{"name":5,"class":6},1]