[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100382373":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":19,"locations":29,"responsibleParty":56,"collaborators":59,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":10,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":10,"enrollmentInfo":72,"targetDuration":10,"studyType":75,"phases":10,"briefSummary":76,"conditions":77,"keywords":80,"overallStatus":32,"whyStopped":10,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Oregon Health and Science University","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Group A: No Surgery Group",null,"This group consists of adults ages 18 or older who have been diagnosed with Fuchs' dystrophy or pseudophakic bullous keratopathy but do not require surgery per standard-of-care guidelines.",{"label":13,"type":10,"description":14,"interventionNames":10},"Group B: Surgery Group","This group consists of adults ages 18 or older who have been diagnosed with Fuchs' dystrophy or pseudophakic bullous keratopathy, who require Descemet's Stripping Endothelial Keratoplasty (DSAEK), Descemet's Membrane Endothelial Keratoplasty (DMEK), or Descemet's Stripping Only (DSO) surgery. All treatment decisions will be made by the attending physician based on standard-of-care guidelines. (The study does not designate a treatment modality or pay for the treatment.)",[16],{"name":17,"affiliation":5,"role":18},"Winston Chamberlain, MD, PhD","PRINCIPAL_INVESTIGATOR",[20,25],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":24},"Humberto Martinez, COT","CONTACT","503-494-7712","martinhu@ohsu.edu",{"name":26,"role":22,"phone":27,"phoneExt":10,"email":28},"Denzil Romfh, OD","503-494-4351","romfhd@ohsu.edu",[30],{"facility":31,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Oregon Health & Science University","RECRUITING","Portland","Oregon","97239","United States","US",{"type":39,"coordinates":40},"Point",[41,42],-122.67621,45.52345,{"lat":42,"lon":41},[45,46,47,50,52,54],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":24},{"name":26,"role":22,"phone":27,"phoneExt":10,"email":28},{"name":48,"role":49,"phone":10,"phoneExt":10,"email":10},"David Huang, MD, PhD","SUB_INVESTIGATOR",{"name":51,"role":49,"phone":10,"phoneExt":10,"email":10},"Afshan Nanji, MD",{"name":53,"role":49,"phone":10,"phoneExt":10,"email":10},"Richard Stutzman, MD",{"name":55,"role":49,"phone":10,"phoneExt":10,"email":10},"Yan Li, PhD",{"type":18,"investigatorFullName":57,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"David Huang","Principal Investigator",[60],{"name":61,"class":62},"National Eye Institute (NEI)","NIH","100382373","oct-in-fuchs-dystrophy-100382373",false,"NCT04258787","OCT in Fuchs' Dystrophy","Evaluating Corneal Edema in Fuchs' Endothelial Dystrophy Using Optical Coherence Tomography","Inclusion Criteria:\n\n* Damaged or diseased corneal endothelium from Fuchs' or PBK\n* Willingness to commit to required study visits\n\nExclusion Criteria:\n\n* Prior Endothelial Keratoplasty (EK) or any other surgery except uncomplicated cataract surgery\n* Presence of a condition that increases the probability for treatment failure (e.g., heavily vascularized cornea, uncontrolled uveitis)\n* Other primary endothelial dysfunction conditions (e.g., posterior polymorphous corneal dystrophy and congenital hereditary corneal dystrophy, iridocorneal endothelial syndrome)\n* Central sub-epithelial or stromal scarring that could impact post-operative clarity assessment\n* Peripheral anterior synechiae in the angle greater than 3 clock hours\n* Hypotony\n* Uncontrolled glaucoma\n* Visually significant optic nerve or macular pathology","ALL","18 Years",{"count":73,"type":74},60,"ESTIMATED","OBSERVATIONAL","This is an observational study using optical coherence tomography (OCT) technology to quantify corneal edema in Fuchs' endothelial dystrophy and predict refractive shift from resolving corneal edema after surgical treatments.",[78,79],"Fuchs Dystrophy","Pseudophakic Bullous Keratopathy",[81,79,82,83],"Fuchs","Optical Coherence Tomography (OCT)","PBK","2025-09-05",{"date":86,"type":87},"2025-09-09","ACTUAL",{"date":89,"type":87},"2020-06-26",{"date":91,"type":74},"2028-06",{"name":5,"class":6},1]