[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100533587":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":39,"locations":48,"responsibleParty":301,"collaborators":304,"id":306,"slug":307,"hasResults":308,"nctId":309,"briefTitle":310,"officialTitle":311,"acronym":312,"eligibilityCriteria":313,"healthyVolunteers":308,"sex":314,"minAge":315,"maxAge":26,"enrollmentInfo":316,"targetDuration":26,"studyType":319,"phases":320,"briefSummary":322,"conditions":323,"keywords":326,"overallStatus":51,"whyStopped":26,"lastUpdateSubmitDate":331,"lastUpdatePostDateStruct":332,"startDateStruct":335,"completionDateStruct":337,"leadSponsor":339,"locationsCount":340},{"fullName":5,"class":6},"Chonnam National University Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Angiography-guided PCI","ACTIVE_COMPARATOR","The PCI procedure in this group will be performed as standard procedure.",[13],"Procedure: Angiography-guided PCI group",{"label":15,"type":16,"description":17,"interventionNames":18},"Optical coherence tomography-guided PCI","EXPERIMENTAL","Use of OCT will be allowed at any step of PCI (pre-PCI, during PCI and post-PCI), but OCT after stent implantation will be mandatory. In this group, the recommendations for selecting reference segment, selecting appropriate size of stent, and stent optimization are as follows. OPTIS imaging catheter (Abbott Vascular) will be used for the imaging arm according to MLD MAX algorithm.",[19],"Procedure: Optical coherence tomography-guided PCI group",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Angiography-guided PCI group","The PCI procedure in this group will be performed as standard procedure. After deployment of stent, stent optimization will be done based on angiographic findings. The optimization guided by angiography should meet the criteria of angiographic residual diameter stenosis less than 10% by visual estimation and the absence of flow limiting dissection (≥Type C dissection). When angiographic under-expansion of the stent is suspected, adjunctive balloon dilatation will be strongly recommended.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Optical coherence tomography-guided PCI group","\\[Stent Optimization\\]\n\n1. Stent Expansion:\n\n   Visually assess residual angiographic diameter stenosis \\\u003C10% \"AND\"\n\n   ① In non-LM lesions: In-stent minimal lumen area (MSA) \\>80% of the average reference lumen area \"OR\" \\>4.5 mm2\n\n   ② In LM lesion: MSA\\>7 mm2 for distal LM and \\>8 mm2 for proximal LM\n2. Stent Apposition:\n\n   No major malapposition (defined as a distance from stent strut to adjacent intima ≥400 um and \\\u003C 1mm length) of the stent over its entire length against the vessel wall\n3. Edge Dissection:\n\nNo major edge dissection in the proximal or distal reference segments, defined as 5 mm from the edge of the stent, extended to media layer with potential to provoke flow disturbances (defined as \\>60° of the circumference of the vessel at site of dissection and\u002For \\>2 mm in length of dissection flap)",[15],[32,36],{"name":33,"affiliation":34,"role":35},"Young Joon Hong, MD, PhD","Chonnam National University","PRINCIPAL_INVESTIGATOR",{"name":37,"affiliation":38,"role":35},"Joo-Yong Hahn, MD, PhD","Samsung Medical Center",[40,45],{"name":41,"role":42,"phone":43,"phoneExt":26,"email":44},"Seung Hun Lee, MD, PhD","CONTACT","82-2-220-6246","lsh8602@naver.com",{"name":33,"role":42,"phone":46,"phoneExt":26,"email":47},"82-2-220-5778","hyj200@hanmail.net",[49,66,77,88,106,124,138,153,169,185,201,214,225,236,247,258,272,287],{"facility":50,"status":51,"city":52,"state":52,"zip":53,"country":54,"countryCode":26,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"Kyungpook National University Hospital","RECRUITING","Daegu","41944","South Korea",{"type":56,"coordinates":57},"Point",[58,59],128.59111,35.87028,{"lat":59,"lon":58},[62,65],{"name":63,"role":42,"phone":26,"phoneExt":26,"email":64},"Nam Kyun Kim, MD, PhD","namkyun.kim@knu.ac.kr",{"name":63,"role":35,"phone":26,"phoneExt":26,"email":26},{"facility":67,"status":51,"city":52,"state":52,"zip":68,"country":54,"countryCode":26,"cosmosGeoPoint":69,"geoPoint":71,"contacts":72},"Yeungnam University Medical Center","42415",{"type":56,"coordinates":70},[58,59],{"lat":59,"lon":58},[73,76],{"name":74,"role":42,"phone":26,"phoneExt":26,"email":75},"Ung Kim, MD, PhD","woongwa@gmail.com",{"name":74,"role":35,"phone":26,"phoneExt":26,"email":26},{"facility":78,"status":51,"city":52,"state":52,"zip":79,"country":54,"countryCode":26,"cosmosGeoPoint":80,"geoPoint":82,"contacts":83},"Daegu Catholic University Medical Center","42472",{"type":56,"coordinates":81},[58,59],{"lat":59,"lon":58},[84,87],{"name":85,"role":42,"phone":26,"phoneExt":26,"email":86},"Jin Bae Lee, MD, PhD","noblewise1@gmail.com",{"name":85,"role":35,"phone":26,"phoneExt":26,"email":26},{"facility":34,"status":51,"city":89,"state":89,"zip":90,"country":54,"countryCode":26,"cosmosGeoPoint":91,"geoPoint":95,"contacts":96},"Gwangju","61469",{"type":56,"coordinates":92},[93,94],126.91556,35.15472,{"lat":94,"lon":93},[97,98,99,100,102,104],{"name":33,"role":42,"phone":26,"phoneExt":26,"email":47},{"name":41,"role":42,"phone":26,"phoneExt":26,"email":44},{"name":33,"role":35,"phone":26,"phoneExt":26,"email":26},{"name":41,"role":101,"phone":26,"phoneExt":26,"email":26},"SUB_INVESTIGATOR",{"name":103,"role":101,"phone":26,"phoneExt":26,"email":26},"Min Chul Kim, MD, PhD",{"name":105,"role":101,"phone":26,"phoneExt":26,"email":26},"Joon Ho Ahn, MD, PhD",{"facility":107,"status":51,"city":108,"state":108,"zip":109,"country":54,"countryCode":26,"cosmosGeoPoint":110,"geoPoint":114,"contacts":115},"Wonkwang University Hospital","Iksan","54538",{"type":56,"coordinates":111},[112,113],126.95444,35.94389,{"lat":113,"lon":112},[116,119,121,123],{"name":117,"role":42,"phone":26,"phoneExt":26,"email":118},"Donghyeon Joo, MD","dhjoozz@naver.com",{"name":120,"role":35,"phone":26,"phoneExt":26,"email":26},"Kyeong Ho Yun, MD, PhD",{"name":122,"role":101,"phone":26,"phoneExt":26,"email":26},"Jae Young Cho, MD, PhD",{"name":117,"role":101,"phone":26,"phoneExt":26,"email":26},{"facility":125,"status":51,"city":126,"state":126,"zip":127,"country":54,"countryCode":26,"cosmosGeoPoint":128,"geoPoint":132,"contacts":133},"International St. Mary's Hospital","Incheon","22711",{"type":56,"coordinates":129},[130,131],126.70515,37.45646,{"lat":131,"lon":130},[134,137],{"name":135,"role":42,"phone":26,"phoneExt":26,"email":136},"Hyung-Bok Park, MD, PhD","hyungbok7@gmail.com",{"name":135,"role":35,"phone":26,"phoneExt":26,"email":26},{"facility":139,"status":51,"city":140,"state":141,"zip":142,"country":54,"countryCode":26,"cosmosGeoPoint":143,"geoPoint":147,"contacts":148},"Jeju National University Hospital","Jeju City","Jeju-do","63241",{"type":56,"coordinates":144},[145,146],126.52194,33.50972,{"lat":146,"lon":145},[149,152],{"name":150,"role":42,"phone":26,"phoneExt":26,"email":151},"Song-Yi Kim, MD, PhD","ttoromom@jejunu.ac.kr",{"name":150,"role":35,"phone":26,"phoneExt":26,"email":26},{"facility":154,"status":51,"city":155,"state":155,"zip":156,"country":54,"countryCode":26,"cosmosGeoPoint":157,"geoPoint":161,"contacts":162},"Jeonbuk National University Hospital","Jeonju","54907",{"type":56,"coordinates":158},[159,160],127.14889,35.82194,{"lat":160,"lon":159},[163,166,168],{"name":164,"role":42,"phone":26,"phoneExt":26,"email":165},"Yi Sik Kim, MD, PhD","dr.kimesik@gmail.com",{"name":167,"role":35,"phone":26,"phoneExt":26,"email":26},"Sang-Rok Lee, MD, PhD",{"name":164,"role":101,"phone":26,"phoneExt":26,"email":26},{"facility":170,"status":51,"city":171,"state":171,"zip":172,"country":54,"countryCode":26,"cosmosGeoPoint":173,"geoPoint":177,"contacts":178},"Gyeongsang National University Hospital","Jinju","52727",{"type":56,"coordinates":174},[175,176],128.08472,35.19278,{"lat":176,"lon":175},[179,182,183],{"name":180,"role":42,"phone":26,"phoneExt":26,"email":181},"Jin-Sin Koh, MD, PhD","kjs0175@gmail.com",{"name":180,"role":35,"phone":26,"phoneExt":26,"email":26},{"name":184,"role":101,"phone":26,"phoneExt":26,"email":26},"Min Gyu Kang, MD, PhD",{"facility":186,"status":51,"city":187,"state":187,"zip":188,"country":54,"countryCode":26,"cosmosGeoPoint":189,"geoPoint":193,"contacts":194},"Kyung Hee University Hospital","Seoul","02447",{"type":56,"coordinates":190},[191,192],126.9784,37.566,{"lat":192,"lon":191},[195,198,199],{"name":196,"role":42,"phone":26,"phoneExt":26,"email":197},"Weon Kim, MD, PhD","mylovekw@hanmail.net",{"name":196,"role":35,"phone":26,"phoneExt":26,"email":26},{"name":200,"role":101,"phone":26,"phoneExt":26,"email":26},"Jong Shin Woo, MD, PhD",{"facility":38,"status":51,"city":187,"state":187,"zip":202,"country":54,"countryCode":26,"cosmosGeoPoint":203,"geoPoint":205,"contacts":206},"06351",{"type":56,"coordinates":204},[191,192],{"lat":192,"lon":191},[207,209,212,213],{"name":37,"role":42,"phone":26,"phoneExt":26,"email":208},"jooyong.hahn@gmail.com",{"name":210,"role":42,"phone":26,"phoneExt":26,"email":211},"Joo Myung Lee, MD, MPH, PhD","drone80@hanmal.net",{"name":37,"role":35,"phone":26,"phoneExt":26,"email":26},{"name":210,"role":101,"phone":26,"phoneExt":26,"email":26},{"facility":215,"status":51,"city":187,"state":187,"zip":216,"country":54,"countryCode":26,"cosmosGeoPoint":217,"geoPoint":219,"contacts":220},"Chung-Ang University Hospital","06973",{"type":56,"coordinates":218},[191,192],{"lat":192,"lon":191},[221,224],{"name":222,"role":42,"phone":26,"phoneExt":26,"email":223},"Wang Soo Lee, MD, PhD","wslee1227@cau.ac.kr",{"name":222,"role":35,"phone":26,"phoneExt":26,"email":26},{"facility":226,"status":51,"city":187,"state":187,"zip":227,"country":54,"countryCode":26,"cosmosGeoPoint":228,"geoPoint":230,"contacts":231},"Ewha Womans University Seoul Hospital","07804",{"type":56,"coordinates":229},[191,192],{"lat":192,"lon":191},[232,235],{"name":233,"role":42,"phone":26,"phoneExt":26,"email":234},"Sanghoon Shin, MD, PhD","nephilla99@gmail.com",{"name":233,"role":35,"phone":26,"phoneExt":26,"email":26},{"facility":237,"status":51,"city":187,"state":187,"zip":238,"country":54,"countryCode":26,"cosmosGeoPoint":239,"geoPoint":241,"contacts":242},"Ewha Womans University Mokdong Hospital","07985",{"type":56,"coordinates":240},[191,192],{"lat":192,"lon":191},[243,246],{"name":244,"role":42,"phone":26,"phoneExt":26,"email":245},"Sodam Jung, MD, PhD","cvdosam@gmail.com",{"name":244,"role":35,"phone":26,"phoneExt":26,"email":26},{"facility":248,"status":51,"city":187,"state":187,"zip":249,"country":54,"countryCode":26,"cosmosGeoPoint":250,"geoPoint":252,"contacts":253},"Korea University Guro Hospital","08308",{"type":56,"coordinates":251},[191,192],{"lat":192,"lon":191},[254,257],{"name":255,"role":42,"phone":26,"phoneExt":26,"email":256},"Dong Oh Kang, MD, PhD","gelly9@naver.com",{"name":255,"role":35,"phone":26,"phoneExt":26,"email":26},{"facility":259,"status":51,"city":260,"state":260,"zip":261,"country":54,"countryCode":26,"cosmosGeoPoint":262,"geoPoint":266,"contacts":267},"St. Carollo Hospital","Suncheon","57931",{"type":56,"coordinates":263},[264,265],127.48784,34.9505,{"lat":265,"lon":264},[268,271],{"name":269,"role":42,"phone":26,"phoneExt":26,"email":270},"Jang Hyun Cho, MD, PhD","goodnew8@naver.com",{"name":269,"role":35,"phone":26,"phoneExt":26,"email":26},{"facility":273,"status":51,"city":274,"state":275,"zip":276,"country":54,"countryCode":26,"cosmosGeoPoint":277,"geoPoint":281,"contacts":282},"Uijeongbu St Mary's Hospital","Uijeongbu-si","Uijeongbu","11765",{"type":56,"coordinates":278},[279,280],127.0474,37.7415,{"lat":280,"lon":279},[283,286],{"name":284,"role":42,"phone":26,"phoneExt":26,"email":285},"Chan Joon Kim, MD, PhD","godandsci@naver.com",{"name":284,"role":35,"phone":26,"phoneExt":26,"email":26},{"facility":288,"status":51,"city":289,"state":289,"zip":290,"country":54,"countryCode":26,"cosmosGeoPoint":291,"geoPoint":295,"contacts":296},"Ulsan University Hospital","Ulsan","44033",{"type":56,"coordinates":292},[293,294],129.31667,35.53722,{"lat":294,"lon":293},[297,300],{"name":298,"role":42,"phone":26,"phoneExt":26,"email":299},"Eun Seok Shin, MD, PhD","sesim1989@gmail.com",{"name":298,"role":35,"phone":26,"phoneExt":26,"email":26},{"type":35,"investigatorFullName":302,"investigatorTitle":303,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Young Joon Hong","Professor",[305],{"name":38,"class":6},"100533587","oct-versus-angiography-for-culprit-lesion-revascularization-in-acute-myocardial-infarction-patients-100533587",false,"NCT06227754","OCT Versus Angiography for Culprit Lesion Revascularization in Acute Myocardial Infarction PatiEnts","Randomized Controlled Trial of Optical Coherence Tomography Versus Angiography for Culprit Lesion Revascularization in Patients With Acute Myocardial Infarction","FRAME-AMI3","Inclusion Criteria:\n\n* Subject must be at least 19 years of age\n* Acute ST-segment elevation myocardial infarction (STEMI)\n\n  \\*STEMI: ST-segment elevation ≥0.1 mV in ≥2 contiguous leads or documented newly developed left bundle-branch block1\n* Primary percutaneous coronary intervention (PCI) in \\\u003C 12 h after the onset of symptoms for STEMI patients\n* Subject is able to verbally confirm understandings of risks, benefits and treatment alternatives of receiving invasive physiologic evaluation and PCI and he\u002Fshe or his\u002Fher legally authorized representative provides written informed consent prior to any study related procedure.\n\nExclusion Criteria:\n\n* Target lesions not amenable for PCI by operators' decision\n* Ostial lesions located in left main vessel or right coronary artery (left main body or distal bifurcation lesions can be enrolled by operator's discretion)\n* Creatinine clearance ≤30 ml\u002Fmin\u002F1.73 m2 and not on dialysis (chronic dialysis dependent patients are eligible for enrolment regardless of creatinine clearance)\n* Cardiogenic shock (Killip class IV) at presentation\n* Intolerance to Aspirin, Clopidogrel, Prasugrel, Ticagrelor, Heparin, or Everolimus\n* Known true anaphylaxis to contrast medium (not allergic reaction but anaphylactic shock)\n* Pregnancy or breast feeding\n* Non-cardiac co-morbid conditions are present with life expectancy \\\u003C2 year or that may result in protocol non-compliance (per site investigator's medical judgment)\n* Unwillingness or inability to comply with the procedures described in this protocol","ALL","19 Years",{"count":317,"type":318},1500,"ESTIMATED","INTERVENTIONAL",[321],"NA","The aim of the study is to compare clinical outcomes between optical coherence tomography-guided versus angiography-guided percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI).",[324,325],"ST Elevation Myocardial Infarction","Myocardial Infarction",[327,328,329,330],"ST-segment elevation MI","Optical coherence tomography","Intravascular imaging","Primary PCI","2026-05-05",{"date":333,"type":334},"2026-05-08","ACTUAL",{"date":336,"type":334},"2024-03-25",{"date":338,"type":318},"2031-12-31",{"name":5,"class":6},18]