[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100495044":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":28,"centralContacts":32,"locations":38,"responsibleParty":56,"collaborators":60,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":71,"acronym":27,"eligibilityCriteria":72,"healthyVolunteers":73,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":27,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":85,"overallStatus":41,"whyStopped":27,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"University of Maryland, Baltimore","OTHER",[8,13,17],{"label":9,"type":6,"description":10,"interventionNames":11},"Control","All control participants will be first be imaged pre-intervention.",[12],"Device: XyCAM with oxygen",{"label":14,"type":6,"description":15,"interventionNames":16},"Glaucoma","All participants with glaucoma will be first be imaged pre-intervention.",[12],{"label":18,"type":6,"description":19,"interventionNames":20},"Pre-perimetric Glaucoma","All participants with pre-perimetric glaucoma will be first be imaged pre-intervention.",[12],[22],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"DEVICE","XyCAM with oxygen","After the standard imaging protocols, participants will be asked to inhale 100% oxygen through a mask and will be re-imaged using the XyCAM RI or XyCAM FC.",[9,14,18],null,[29],{"name":30,"affiliation":5,"role":31},"Grace Forbes, MS","STUDY_DIRECTOR",[33],{"name":34,"role":35,"phone":36,"phoneExt":27,"email":37},"Osamah J Saeedi, MD, MS","CONTACT","(410) 328-5929","osaeedi@som.umaryland.edu",[39],{"facility":40,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"University of Maryland Eye Associates at Redwood","RECRUITING","Baltimore","Maryland","21201","United States","US",{"type":48,"coordinates":49},"Point",[50,51],-76.61219,39.29038,{"lat":51,"lon":50},[54],{"name":55,"role":35,"phone":27,"phoneExt":27,"email":27},"Osamah Saeedi, MD, MS",{"type":57,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":27,"oldOrganization":27},"PRINCIPAL_INVESTIGATOR","Osamah Saeedi","Professor",[61,64],{"name":62,"class":63},"National Eye Institute (NEI)","NIH",{"name":65,"class":66},"Vasoptic Medical, Inc","UNKNOWN","100495044","ocular-blood-flow-imaging-for-glaucoma-assessment-100495044",false,"NCT05726058","Ocular Blood Flow Imaging for Glaucoma Assessment","Inclusion Criteria:\n\n* Age 18 and older with binocular vision\n* Able to provide informed consent\n* Patient is a healthy control OR is recommended for glaucoma assessment OR diagnosed with moderate to severe glaucoma in at least one eye as determined by Hodapp Anderson Criteria\n\nExclusion Criteria:\n\n* The subject has significant media opacity (e.g., a visually significant cataract or significant corneal scar)\n* The subject has previous ocular surgery other than uncomplicated cataract extraction, laser trabeculoplasty (ALT or SLT), or YAG capsulotomy\n* The subject has prior ocular disease other than glaucoma\n* The subject has anatomically narrow angles or a prior adverse reaction to administration of Tropicamide or fluorescein dye\n* The subject has more than 15 diopters of refractive error\n* The subject is a female who is pregnant or nursing\n* The subject has diabetes mellitus",true,"ALL","18 Years","88 Years",{"count":78,"type":79},150,"ESTIMATED","INTERVENTIONAL",[82],"NA","The goal of this clinical trial is to investigate the use of an FDA-cleared retinal blood flow imaging instrument called the XyCAM RI and XyCAM FC (Vasoptic Medical, Inc., Columbia, MD) in glaucoma management.\n\nThe main question it aims to answer are:\n\n* Can the investigators use blood flow to discriminate between eyes with early-stage glaucoma and variable-matched controls?\n* Can the investigators validate that the XyCAM FC simultaneously captures both stereo fundus photography and ocular blood flow monitoring?\n\nParticipants will be\n\n* measured for their blood pressure, heart rate, height, and weight\n* dilated with tropicamide\n* imaged using the XyCAM RI, fundus photography, optical coherence tomography, and standard automated perimetry\n* imaged using the XyCAM RI while inhaling 100% oxygen through a mask",[14],[86,87,88,89,90,91,92],"glaucoma","xycam","blood flow","imaging","ophthalmology","retinal blood flow","eye disease","2026-06-30",{"date":95,"type":96},"2026-07-02","ACTUAL",{"date":98,"type":96},"2023-03-30",{"date":100,"type":79},"2028-04-30",{"name":5,"class":6},1]