[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623379":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":20,"centralContacts":25,"locations":32,"responsibleParty":47,"collaborators":20,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":20,"eligibilityCriteria":57,"healthyVolunteers":58,"sex":59,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":20,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":20,"overallStatus":71,"whyStopped":20,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"Aalborg University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"off-set analgesia","EXPERIMENTAL","The tests of off-set analgesia will be performed using a TSA2 (Medoc Ltd, Israel) thermal sensory testing device. Two protocols will be applied: heat off-set analgesia and cold off-set analgesia.",[13,14],"Other: Heat off-set analgesia","Other: Cold off-set analgesia",[16,21],{"type":6,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"Heat off-set analgesia","The tests of off-set analgesia will be performed using a TSA2 (Medoc Ltd, Israel) thermal sensory testing device",[9],null,{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":20},"Cold off-set analgesia","The tests of off-set analgesia will be performed using a TSA2 (Medoc Ltd, Israel) thermal sensory testing device.",[9],[26],{"name":27,"role":28,"phone":29,"phoneExt":30,"email":31},"Silvia Lo Vecchio, PhD","CONTACT","21397785","0045","slv@hst.aau.dk",[33],{"facility":34,"status":20,"city":35,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Center for Neuroplasticity and Pain Faculty of Medicine, Aalborg University Selma Lagerløfs Vej 249 9260 Gistrup, Denmark","Aalborg","9620","Denmark","DK",{"type":40,"coordinates":41},"Point",[42,43],9.9187,57.048,{"lat":43,"lon":42},[46],{"name":27,"role":28,"phone":29,"phoneExt":30,"email":31},{"type":48,"investigatorFullName":49,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"PRINCIPAL_INVESTIGATOR","Silvia Lo Vecchio","Associate Professor","100623379","off-set-analgesia-induced-by-cold-temperature-100623379",false,"NCT07395869","Off-set Analgesia Induced by Cold Temperature","Pain and Itch Neuromodulation: Effects of Offset Analgesia, Placebo, and Nocebo and Topographical Distribution of Itch and Pain Receptors","Inclusion Criteria:\n\n* Healthy men and women\n* 18-60 years\n* Speak and understand English\n\nExclusion Criteria:\n\n* Pregnancy or lactation\n* Drug addiction defined as any use of cannabis, opioids, or other drugs\n* Previous or current history of neurological, immunological, musculoskeletal, cardiac disorder or psychiatric diagnoses that may affect the results (e.g., neuropathy, muscular pain in the upper extremities, anxiety, depression, schizophrenia, etc.)\n* Moles, wounds, scars, or tattoos in the area to be treated or tested\n* Current use of medications that may affect the trial such as antihistamines and pain killers\n* Skin diseases\n* Consumption of alcohol or painkillers 24 hours before the study days and between these\n* Acute or chronic pain and itch\n* Participation in other trials within 1 week of study entry (4 weeks in the case of pharmaceutical studies)\n* Contraindications to capsaicin, including intolerance to chili or burns or wounds at the application site (sub-project 4 only)\n* The subject is assessed as unable to engage in the necessary cooperation required by the study",true,"ALL","18 Years","60 Years",{"count":63,"type":64},30,"ESTIMATED","INTERVENTIONAL",[67],"NA","In this study, it will be investigated if the phenomenon of offset analgesia, usually associated with painful heat stimulation, could also be induced using cold painful temperatures.",[70],"Pain","NOT_YET_RECRUITING","2026-02-09",{"date":74,"type":75},"2026-02-11","ACTUAL",{"date":77,"type":64},"2026-02-15",{"date":79,"type":64},"2028-12-31",{"name":5,"class":6},1]