[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100604708":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":27,"responsibleParty":53,"collaborators":56,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":20,"eligibilityCriteria":66,"healthyVolunteers":62,"sex":67,"minAge":68,"maxAge":20,"enrollmentInfo":69,"targetDuration":20,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":79,"overallStatus":30,"whyStopped":20,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"University of Maryland, Baltimore","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Smartphone-based assessments and cognitive tasks","EXPERIMENTAL","All participants will complete a baseline session to colelct data related to demographics, health history\u002Fstatus, and cognitive functioning. Participants will be oriented to the smartphone application which is delivered via NeuroUX cloud-based technology which send a text message to the smartphone as a prompt for tasks which will be administered across 15 days. All participants complete the same tasks and duration of tasks. Then all participants complete a follow-up assessment to examine their preferences related to the smartphone and cognitive function.",[13],"Behavioral: Smartphone based cognitive tasks",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"BEHAVIORAL","Smartphone based cognitive tasks","15 days Smartphone\u002FCellphone tasks: Using NeuroUX smartphone testing software, Cognitive \"games\"\u002Ftasks lasting approximately 3-4 minutes each will be administered through the a smartphone application and will be prompted via text message twice per day across 15 consecutive days in the morning (8-11am) and evening (5-8). Tasks were chosen to measure aspects of diverse aspects of cognitive that are impaired among patients taking methadone, including N-back task (working memory), the Stroop Task (executive function\u002Fcognitive control), and the Variable Difficulty List Memory Test (learning and memory). The 15 days will include two types of task administration: a) Testing Phase: tasks administered at a consistent, fixed difficulty level (days 1-5) b) Remediation Phase: increasing task difficulty in response to participant performance (days 6-15). To encourage adherence, researchers will contact participants to remind them of task completion.",[9],null,[22],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Bethea A Kleykamp, PhD, MA","CONTACT","4104020252","bkleykamp@som.umaryland.edu",[28],{"facility":29,"status":30,"city":31,"state":32,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"UM Addiction Treatment Programs at 1001 West Pratt","RECRUITING","Baltimore","Maryland","21124","United States","US",{"type":37,"coordinates":38},"Point",[39,40],-76.61219,39.29038,{"lat":40,"lon":39},[43,47,50],{"name":44,"role":24,"phone":45,"phoneExt":20,"email":46},"Eric Weintraub, MD","443-462-3400","Eweintra@som.umaryland.edu",{"name":48,"role":24,"phone":45,"phoneExt":20,"email":49},"Heather Fitzsimmons","HFitzsimons@som.umaryland.edu",{"name":51,"role":52,"phone":20,"phoneExt":20,"email":20},"Bethea Kleykamp, PhD","PRINCIPAL_INVESTIGATOR",{"type":52,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"Bethea A Kleykamp","Assistant Professor, Psychiatry, University of Maryland School of Medicine",[57],{"name":58,"class":59},"National Institute on Aging (NIA)","NIH","100604708","older-adults-methadone-and-cognitive-function-100604708",false,"NCT07153029","Older Adults, Methadone, and Cognitive Function","Cognitive Functioning Among Older Adults in Methadone Treatment for Opioid Use Disorder","Inclusion Criteria:\n\n* age 55 and older\n* currently in outpatient methadone treatment for opioid use disorder\n* participant is alert\u002Fable to communicate\u002Fable to give acceptable answers on the \"Evaluation to Sign Consent form\n* participant has normal or correct to normal vision\n\nExclusion Criteria:\n\n* age 54 or younger\n* not in methadone treatment for opioid use disorder","ALL","55 Years",{"count":70,"type":71},30,"ESTIMATED","INTERVENTIONAL",[74],"NA","The increasing prevalence of opioid use disorder (OUD) among older adults, coupled with high overdose rates and cognitive impairments associated with opioid use, highlights a critical gap in addiction treatment. Cognitive impairments can persist despite treatment and negatively impact recovery outcomes, yet cognitive screening and interventions are rarely integrated into OUD care. This study aims to evaluate the feasibility of remotely delivered, smartphone-based cognitive assessments (administered through NeuroUX web-based software) for older adults (55+) in methadone treatment. The tasks have been \"gamified\" to make them engaging and brief, which could be appealing to patients. They will complete the tasks for 15 days using the phone provided or their own phone. During days 6-15 of testing, tasks will become incrementally more difficult based on participant performance to assess the feasibility of cognitive training. Cognitive training uses engaging games or tasks to strengthen thinking skills like memory and focus, much like physical exercise strengthens the body. Adherence, acceptability, and usability of the tasks will be assessed. Secondary analyses will explore relationships between task performance and participant characteristics (e.g., baseline cognitive functioning, methadone dose, timing of methadone dose). Findings from this pilot study will provide foundational data for a future grant application to develop and test digital cognitive assessment and training interventions tailored to older adults in addiction treatment. By addressing a critical yet understudied aspect of OUD care this research has the potential to enhance treatment engagement, improve clinical outcomes, and support long-term recovery in the growing older population.",[77,78],"Opioid Use Disorder","Cognitive Ability General",[80,81,82,83],"older adults","cognition","feasibility","ecological momentary assessment","2026-06-01",{"date":86,"type":87},"2026-06-03","ACTUAL",{"date":89,"type":87},"2024-12-03",{"date":91,"type":71},"2026-07-01",{"name":5,"class":6},1]