[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100641309":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":19,"locations":25,"responsibleParty":42,"collaborators":44,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":10,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":55,"minAge":56,"maxAge":10,"enrollmentInfo":57,"targetDuration":10,"studyType":60,"phases":10,"briefSummary":61,"conditions":62,"keywords":10,"overallStatus":64,"whyStopped":10,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":74},{"fullName":5,"class":6},"Medical University of South Carolina","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Older Adults With and Without Olfactory Dysfunction",null,"Adults aged 50 years and older enrolled in a prospective cohort study assessing olfactory function, cognition, biomarkers, and quality of life, with annual follow-up. Participants will be classified post hoc into olfactory phenotypes based on testing results.",[13],"Other: Clinical and Biomarker Assessments",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"Clinical and Biomarker Assessments","Participants undergo olfactory testing (Sniffin' Sticks), cognitive assessment, nasal endoscopy, olfactory mucus collection, MRI imaging (subset), and patient-reported outcome measures to evaluate olfactory function, biomarkers, and health outcomes over time.",[9],[20],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":24},"Rodney Schlosser, MD","CONTACT","18437927165","schlossr@musc.edu",[26],{"facility":27,"status":10,"city":28,"state":29,"zip":30,"country":31,"countryCode":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"MUSC","Charleston","South Carolina","29425","United States","US",{"type":34,"coordinates":35},"Point",[36,37],-79.93275,32.77632,{"lat":37,"lon":36},[40],{"name":21,"role":22,"phone":41,"phoneExt":10,"email":24},"8437927165",{"type":43,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[45],{"name":46,"class":47},"National Institute on Deafness and Other Communication Disorders (NIDCD)","NIH","100641309","olfactory-dysfunction-in-aging-adults-100641309",false,"NCT07660887","Olfactory Dysfunction in Aging Adults","Inclusion Criteria:\n\n* Age: 50 years or older\n* Ability to follow instructions and understand consent process in English\n* Adequate visual, auditory, or motor functioning to complete items in the test battery or availability of assistance or assist devices to complete tasks\n\nExclusion Criteria:\n\n\\- Vulnerable populations including prisoners or institutionalized individuals",true,"ALL","50 Years",{"count":58,"type":59},500,"ESTIMATED","OBSERVATIONAL","This prospective longitudinal cohort study will enroll adults aged 50 years and older to characterize olfactory dysfunction in aging. Participants will undergo comprehensive olfactory testing, cognitive assessment, biomarker collection, and imaging to identify clinically relevant phenotypes based on anatomic site of dysfunction. The study will also evaluate the impact of olfactory dysfunction on quality of life and identify baseline factors associated with changes in olfactory function over time.",[63],"Olfactory Dysfunction","NOT_YET_RECRUITING","2026-06-16",{"date":67,"type":68},"2026-06-22","ACTUAL",{"date":70,"type":59},"2027-04-01",{"date":72,"type":59},"2032-04-30",{"name":5,"class":6},1]