[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100641768":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":21,"centralContacts":26,"locations":35,"responsibleParty":53,"collaborators":10,"id":55,"slug":10,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":10,"eligibilityCriteria":60,"healthyVolunteers":56,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":10,"studyType":67,"phases":10,"briefSummary":68,"conditions":69,"keywords":72,"overallStatus":75,"whyStopped":10,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"National Institutes of Health Clinical Center (CC)","NIH",[8,12,15,18],{"label":9,"type":10,"description":11,"interventionNames":10},"HIV- & SUD-",null,"Individuals without HIV and without an SUD",{"label":13,"type":10,"description":14,"interventionNames":10},"HIV- & SUD+","Individuals without HIV and with an SUD",{"label":16,"type":10,"description":17,"interventionNames":10},"HIV+ & SUD-","Individuals with HIV and without an SUD",{"label":19,"type":10,"description":20,"interventionNames":10},"HIV+ & SUD+","Individuals with HIV and with an SUD",[22],{"name":23,"affiliation":24,"role":25},"Thorsten Kahnt, Ph.D.","National Institute on Drug Abuse (NIDA)","PRINCIPAL_INVESTIGATOR",[27,32],{"name":28,"role":29,"phone":30,"phoneExt":10,"email":31},"NIDA IRP Screening Team","CONTACT","(800) 535-8254","researchstudies@nida.nih.gov",{"name":23,"role":29,"phone":33,"phoneExt":10,"email":34},"(667) 312-5175","thorsten.kahnt@nih.gov",[36],{"facility":37,"status":10,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"National Institute on Drug Abuse","Baltimore","Maryland","21224","United States","US",{"type":44,"coordinates":45},"Point",[46,47],-76.61219,39.29038,{"lat":47,"lon":46},[50],{"name":51,"role":29,"phone":52,"phoneExt":10,"email":34},"Thorsten Kahnt","667-312-5175",{"type":54,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100641768",false,"NCT07637669","Olfactory Function and Model-Based Behavior in People Living With HIV and SUD","Olfactory Function and Model-based Behavior in People Living With HIV and SUD","* INCLUSION CRITERIA:\n\nIn order to be eligible to participate in this study, an individual must meet all of the following criteria:\n\nFor all participants:\n\n* Stated willingness to comply with all study procedures and availability for the duration of the study\n* Aged 18-65 years old. Justification: prevalence of olfactory impairments increases with age; after age 53, the prevalence is 24.5 percent, increasing to 62.5 percent in people ages 80-97.\n* Agreement to adhere to Lifestyle Considerations throughout study duration.\n* Ability of subject to understand and the willingness to sign a written informed consent document.\n\nFor participants in the HIV+ and SUD+ and HIV+ and SUD- groups:\n\n-HIV positive.\n\nFor participants in the HIV+ and SUD+ and HIV- \\& SUD+ groups:\n\n-Substance Use Disorder (SUD) other than Alcohol Use Disorder (AUD) or Tobacco Use Disorder (TUD).\n\nEXCLUSION CRITERIA:\n\nAn individual who meets any of the following criteria will be excluded from participation in this study:\n\nFor all participants:\n\n* History of neurological illnesses or neurosurgery including but not limited to cerebrovascular accident, Parkinson disease, Alzheimer disease, Huntington disease, central nervous system (CNS) tumor, significant head trauma with sequelae, multiple sclerosis or other demyelinating diseases, epilepsy, movement disorders. The MAI will also retain discretion to exclude based on a history of a neurological illness or trauma that may compromise data integrity.\n* History of current (past 12 months) uncontrolled major DSM-5 psychiatric disorder including major affective disorder, obsessive-compulsive disorder, schizophrenia, or posttraumatic stress disorder, excluding SUD.\n* Candidates who recently (12 hours prior to a study visit) used medications and\u002For substances that are psychoactive or otherwise affect alertness will have to pass a clinical assessment for intoxication on the day of the study visit. Based on participant preferences and MAI\u002FPI judgment, participants who fail the clinical assessment for intoxication will either be withdrawn or rescheduled.\n* History of clinically significant anaphylaxis, e.g., due to severe asthma or food and nonfood allergies (e.g., latex, detergents, soap, etc.). The MAI will retain discretion to exclude a participant based on this criterion.\n* Uncorrected impairments in visual acuity.\n* Non-English speaking. Justification: The data integrity of some of the behavioral tasks used in this study would be compromised as they have only been validated in English.\n* Pregnancy.\n* Any other condition that in the judgment of the investigators is incompatible with participation.\n\nFor participants in the HIV+ and SUD- and HIV- and SUD- groups:\n\n* History of current (past 12 months) SUD, excluding tobacco use disorder.\n* Pattern of alcohol and drug use in the past 12 months that is indicative of harmful use, loss of control over use, or physical dependence.\n* Daily alcohol or drug use (excluding caffeine and nicotine) for at least 4 continuous weeks in the past 12 months.\n\nFor participants in the HIV- and SU+ and HIV- and SUD- groups:\n\n-HIV positive.\n\nFor the Optional MRI Segment:\n\n-Unable to undergo MRI scanning due to certain metallic or magnetic devices or implants in the body, or claustrophobia.","ALL","18 Years","65 Years",{"count":65,"type":66},120,"ESTIMATED","OBSERVATIONAL","Background:\n\nHuman immunodeficiency virus (HIV) infection can affect areas of the brain that control thinking ability. These same areas of the brain also control the sense of smell. HIV infection is common in people with substance use disorder (SUD). SUD also affects thinking ability. Researchers want to learn more about the connection between the sense of smell and decision-making ability in people with HIV, SUD, or both.\n\nObjective:\n\nTo test the sense of smell in people with HIV and\u002For SUD and how they make choices based on odors.\n\nEligibility:\n\nPeople aged 18 to 65 years with any of these: (1) HIV, (2) SUD, (3) both HIV and SUD, or (4) neither SUD nor HIV.\n\nDesign:\n\nParticipants will have 2 visits. Each visit will last 3 to 5 hours.\n\nIn visit 1, participants will have a blood draw and a saliva swab. They will answer questions about their health, sleep habits, food intake, and substance use. They will have smell tests:\n\nThey will smell scented sticks and answer questions about them. They will be blindfolded for some tests.\n\nThey will perform tasks on a computer. They will look at pictures and smell pleasant food odors, such as chocolate cake or pizza. Smells will be delivered using a nasal mask. Their sniffing and breathing will be measured. They may also be exposed to odor-free air. They will eat food that corresponds to one of the food odors they smelled.\n\nIn visit 2, participants will do a saliva swab and a different computer task that involves odors. They will also have tests of their attention and memory. Participants may opt to have an imaging scan of the brain.",[70,71],"HIV","Substance Use Disorder",[70,71,73,74],"Olfaction","Decision Making","NOT_YET_RECRUITING","2026-07-01",{"date":78,"type":79},"2026-07-02","ACTUAL",{"date":81,"type":66},"2026-07-07",{"date":83,"type":66},"2031-06-27",{"name":24,"class":6},1]