[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100467236":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":34,"locations":42,"responsibleParty":56,"collaborators":25,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":25,"eligibilityCriteria":65,"healthyVolunteers":61,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":25,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":25,"overallStatus":44,"whyStopped":25,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Pamela Youde Nethersole Eastern Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Treatment arm","EXPERIMENTAL","Olfactory training by neurological chemosensory stimulation using aromatic substances delivered via diffusers. Four aromatic substances will be used. Each substance will be given for 20 seconds sequentially, providing a total of 80 seconds of olfactory stimulation three times per day for 3 months.",[13],"Other: Olfactory Training",{"label":15,"type":16,"description":17,"interventionNames":18},"Control arm","PLACEBO_COMPARATOR","Same diffuser will be given to control group. All of the four essential oils will be replaced by normal saline using the same packing. Same treatment regime of 20 seconds for each diffuser three times per day for 3 months will be instructed to control group patients.",[19],"Other: Control",[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Olfactory Training","Four aromatic substances will be used (Citrus limon, Eucalyptus radiata, Pelargonium graveolens, Juniperus virginiana)",[9],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Control","Normal Saline will be used",[15],[31],{"name":32,"affiliation":5,"role":33},"Kai Chuen Fergus Wong, FRCSEd(ORL)","PRINCIPAL_INVESTIGATOR",[35,39],{"name":32,"role":36,"phone":37,"phoneExt":25,"email":38},"CONTACT","64600771","wkc568@ha.org.hk",{"name":40,"role":36,"phone":41,"phoneExt":25,"email":25},"Ka Chung Kwan, FRCSEd(ORL)","64600056",[43],{"facility":5,"status":44,"city":45,"state":25,"zip":25,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"RECRUITING","Hong Kong","HK",{"type":48,"coordinates":49},"Point",[50,51],114.17469,22.27832,{"lat":51,"lon":50},[54],{"name":55,"role":36,"phone":25,"phoneExt":25,"email":25},"Kai-Chuen, Fergus Wong",{"type":33,"investigatorFullName":57,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Fergus Wong Kai Chuen","Associate Consultant","100467236","olfactory-training-on-smell-dysfunction-patients-in-hk-100467236",false,"NCT05364125","Olfactory Training on Smell Dysfunction Patients in HK","Effect of Olfactory Training on Olfactory Dysfunction Patients in Hong Kong Population","Inclusion Criteria:\n\n* Olfactory dysfunction \\> 6 months and \\\u003C 5 years\n\nExclusion Criteria:\n\n* History of significant head injury (fracture, ICH)\n* History of brain surgery\n* History of nasal surgery\n* Active nasal disease\n* Active neurological disease\n* Poor premorbid status\u002F non-communicable patients\n* Mentally incompetent patients\n* \\\u003C18 years' old\n* Pregnancy\n* Hypersensitivity to the aromatic substance.","ALL","18 Years","70 Years",{"count":70,"type":71},80,"ESTIMATED","INTERVENTIONAL",[74],"NA","* Causes of olfactory dysfunction can be classified into conductive and sensorineural causes.\n* Conductive causes are mainly due to structural nasal problem, which can be treated by nasal surgery\n* Sensorineural causes included post-infection, post-head injury, post Head and Neck irradiation and other central nervous system diseases.\n* Olfactory Training is well established treatment for sensorineural olfactory dysfunction in foreign countries.\n* Olfactory Training by neurological chemosensory stimulation using aromatic substances delivered via electronic portable aromatic rehabilitation (EPAR) diffuser was proved to be effective treatment in COVID-19 related olfactory dysfunction in recent Hong Kong study.\n* However, there is a lack of local study on the effect of Olfactory Training in other non-COVID-19 sensorineural causes of olfactory dysfunction in Hong Kong population.",[77,78,79,80,81,82,83],"Olfaction Disorders","Smell Disorders","Anosmia","Hyposmia","Olfactory Impairment","Smell Loss","Smell Dysfunction","2025-05-28",{"date":86,"type":87},"2025-06-03","ACTUAL",{"date":89,"type":87},"2022-07-01",{"date":91,"type":71},"2027-06-30",{"name":5,"class":6},1]