[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100502429":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":43,"responsibleParty":62,"collaborators":26,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":26,"eligibilityCriteria":71,"healthyVolunteers":72,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":26,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":85,"overallStatus":46,"whyStopped":26,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Indiana University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Fish Oil (Omega-3 Fatty Acids)","EXPERIMENTAL","15 subjects will ingest 6 capsules of fish oil of per day for 12 weeks",[13],"Dietary Supplement: Fish Oil",{"label":15,"type":16,"description":17,"interventionNames":18},"Olive Oil","PLACEBO_COMPARATOR","15 subjects will ingest 6 capsules of olive oil per day for 12 weeks",[19],"Dietary Supplement: Placebo",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIETARY_SUPPLEMENT","Fish Oil","For 12 weeks subjects will ingest 6 capsules per day of fish oil (7.8 g\u002Fday total omega--3 fatty acids: 3.75 g\u002Fday EPA and 1.5 g\u002Fday DHA)",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Placebo","For 12 weeks subjects will ingest 6 capsules per day of olive oil (each capsule contains 990 mg of olive oil)",[15],[32],{"name":33,"affiliation":5,"role":34},"Timothy D Mickleborough, PhD","PRINCIPAL_INVESTIGATOR",[36,40],{"name":33,"role":37,"phone":38,"phoneExt":26,"email":39},"CONTACT","812-855-0753","tmickleb@indiana.edu",{"name":41,"role":37,"phone":26,"phoneExt":26,"email":42},"Abigail S Sogard, B.S.","asogard@iu.edu",[44],{"facility":45,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Human Perfromance Lab, Indiana University","RECRUITING","Bloomington","Indiana","47405","United States","US",{"type":53,"coordinates":54},"Point",[55,56],-86.52639,39.16533,{"lat":56,"lon":55},[59],{"name":60,"role":37,"phone":26,"phoneExt":26,"email":61},"Timothy Mickleborough, PhD","tmickleb@inidana.edu",{"type":34,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Tim Mickleborough","Professor of Kinesiology","100502429","omega-3-fatty-acids-as-regulators-of-brown-adipose-tissue-during-cold-exposure-100502429",false,"NCT05822141","Omega-3 Fatty Acids as Regulators of Brown Adipose Tissue During Cold Exposure","Omega-3 Fatty Acid Modulation of Brown Adipose Tissue for Arctic Resilience","Inclusion Criteria:\n\n* Male and female, between the ages of 18 to 40 years.\n* Body Mass Index (BMI) of 18.5 to 24.9 kg\u002Fm2\n* Considered \"moderately to highly active\" by the International Physical Activity Questionnaire (IPAQ) and the Physical Activity Readiness Questionnaire (PAR-Q+)\n\nExclusion Criteria:\n\n* History of smoking or recreational smoking, hyperlipidemia, hypertension\u002Fcardiovascular disease, diabetes, renal disease, neurological disease, metabolic disease, and bleeding disorders or delayed clotting time.\n* Taking SSRI's (antidepressants and anxiety medication), ADD\u002FADHD medication, and chronically consume pain medication (Aleve, Tylenol, CBD, etc).\n* Have or have had chronic disorders of the rectum (e.g., cancer, surgery, active hemorrhoids, etc.) or who currently have related acute conditions (diarrhea, constipation, etc.).\n* Have or have had a diagnosis of disorders related to immune suppression and\u002For autoimmune disease.\n* Are pregnant or planning on being pregnant.\n* Resting blood pressure of \\> 130mmHg systolic or 90 mmHg diastolic.\n* Resting Pulse rate of \\> 100 bpm.\n* History of regularly consuming fish oil supplements and\u002For regularly eating more than one fish meal per week.\n* Consuming more than one fish meal per week during the study.",true,"ALL","18 Years","40 Years",{"count":77,"type":78},30,"ESTIMATED","INTERVENTIONAL",[81],"NA","This clinical trial will assess the whether fish oil supplementation can modulate brown fat activation, shivering, thermal comfort and skin blood flow during cold exposure.",[84],"Cold Exposure",[86,87,88],"Brown fat","Fish oil","Cold","2026-05-21",{"date":91,"type":92},"2026-05-26","ACTUAL",{"date":94,"type":92},"2023-06-12",{"date":96,"type":78},"2026-12",{"name":5,"class":6},1]