[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100644677":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":27,"centralContacts":32,"locations":39,"responsibleParty":57,"collaborators":60,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":67,"eligibilityCriteria":68,"healthyVolunteers":63,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":60,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":83,"overallStatus":41,"whyStopped":60,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Al-Azhar University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Omega-3 Plus Low-Dose Aspirin","EXPERIMENTAL","Participants receive scaling and root planing followed by omega-3 fatty acids (EPA 640 mg and DHA 480 mg daily) plus low-dose aspirin (75 mg daily) for 6 months.",[13],"Drug: Omega-3 Fatty Acids (EPA plus DHA) plus low dose aspirin",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo Control","PLACEBO_COMPARATOR","Participants receive scaling and root planing followed by placebo capsules for 6 months.",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Omega-3 Fatty Acids (EPA plus DHA) plus low dose aspirin","Matching placebo capsules administered orally once daily for 6 months following scaling and root planing.",[9,15],[26],"placebo",[28],{"name":29,"affiliation":30,"role":31},"naglaa M EL wakeel, professor","Faculty of Dental Medicine for Girls, Al-Azhar University","PRINCIPAL_INVESTIGATOR",[33],{"name":34,"role":35,"phone":36,"phoneExt":37,"email":38},"ALAA hesham mah,oud, BDS, MSc Candidate","CONTACT","+201146816128","+2","alaahesham419@gmail.com",[40],{"facility":30,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"RECRUITING","Cairo","Cairo Governorate","11651","Egypt","EG",{"type":48,"coordinates":49},"Point",[50,51],31.24967,30.06263,{"lat":51,"lon":50},[54,56],{"name":55,"role":35,"phone":36,"phoneExt":37,"email":38},"Alaa H mahmoud, BDS, MSc Candidate",{"name":34,"role":35,"phone":36,"phoneExt":37,"email":38},{"type":31,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":60,"oldOrganization":60},"Alaa hesham Mahmoud","Master's Degree Candidate, Department of Oral Medicine, Periodontology, Oral Diagnosis and Radiology",null,"100644677","omega-3-plus-low-dose-aspirin-in-smokers-with-stage-iii-periodontitis-100644677",false,"NCT07673185","Omega-3 Plus Low-Dose Aspirin in Smokers With Stage III Periodontitis","Clinical and Biochemical Evaluation of the Effect of Omega-3 Fatty Acids Plus Low-Dose Aspirin as an Adjunct to Non-Surgical Periodontal Therapy in Smoker Patients With Stage III Periodontitis: A Randomized Double-Blind Placebo-Controlled Clinical Trial","OASP","Inclusion Criteria:\n\n* \\- Male or female smokers aged 30 to 50 years.\n* Diagnosed with Stage III periodontitis according to the 2017 World Workshop classification.\n* Probing pocket depth (PPD) ≥ 5 mm.\n* Clinical attachment loss (CAL) ≥ 5 mm.\n* Presence of at least 20 natural teeth.\n* Willing and able to provide written informed consent.\n\nExclusion Criteria:\n\n* \\- Systemic diseases affecting periodontal health.\n* Pregnancy or lactation.\n* Periodontal treatment within the previous 6 months.\n* Use of antibiotics or anti-inflammatory drugs within the previous 6 months.\n* Allergy or hypersensitivity to omega-3 fatty acids or aspirin.\n* Long-term anticoagulant therapy.\n* History of gastric ulcer or bleeding disorders.\n* Participation in another clinical trial within the previous 3 month","ALL","30 Years","50 Years",{"count":73,"type":74},40,"ESTIMATED","INTERVENTIONAL",[77],"NA","This randomized double-blind placebo-controlled clinical trial aims to evaluate the clinical and biochemical effects of omega-3 fatty acids combined with low-dose aspirin as an adjunct to scaling and root planing (SRP) in smoker patients with Stage III periodontitis. The study compares test and control groups regarding periodontal clinical parameters and gingival crevicular fluid interleukin-1 beta (IL-1β) levels Or other inflammatory markers that will be determined later at baseline, 3 months, and 6 months following treatment",[80,81,82],"Periodontal Disease","Periodontitis (Stage 3)","Smoking Behaviors",[84,85,86],"omega 3","smoker","stage 3","2026-06-23",{"date":89,"type":90},"2026-06-29","ACTUAL",{"date":92,"type":90},"2025-01-15",{"date":94,"type":74},"2026-10-30",{"name":5,"class":6},1]