[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100503374":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":13,"centralContacts":20,"locations":26,"responsibleParty":43,"collaborators":7,"id":45,"slug":46,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":7,"eligibilityCriteria":51,"healthyVolunteers":47,"sex":52,"minAge":53,"maxAge":7,"enrollmentInfo":54,"targetDuration":7,"studyType":57,"phases":7,"briefSummary":58,"conditions":59,"keywords":67,"overallStatus":69,"whyStopped":7,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"Sociedad de Lucha Contra el Cáncer del Ecuador","OTHER",null,[9],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":7},"DIAGNOSTIC_TEST","Plasma metabolomic profile by Ultra-high performance liquid chromatography with quadrupole time-of-flight mass spectrometry (UPLC-QTOFMS)","For metabolomic analysis, different portions of the blood (plasma and lymphocytes) will be subjected to metabolite extraction by the extraction method defined by Glasgow Polyomics. With protein precipitation, 200 microliters (uL) of the fluid with the metabolites is transferred to a new microtube and must be maintained at -80 °C until the time of metabolomic analysis.",[14,17],{"name":15,"affiliation":5,"role":16},"Katherine García Matamoros, MD","PRINCIPAL_INVESTIGATOR",{"name":18,"affiliation":19,"role":16},"Fernanda Bertuccez Cordeiro, PhD","Escuela Superior Politécnica del Litoral",[21],{"name":15,"role":22,"phone":23,"phoneExt":24,"email":25},"CONTACT","5933718300","2385","comite_investigacion@solca.med.ec",[27],{"facility":28,"status":7,"city":29,"state":30,"zip":31,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"Instituto Oncológico Nacional Dr. Juan Tanca Marengo","Guayaquil","Guayas","090505","Ecuador","EC",{"type":35,"coordinates":36},"Point",[37,38],-79.88621,-2.19616,{"lat":38,"lon":37},[41],{"name":42,"role":22,"phone":23,"phoneExt":24,"email":25},"Katherine García Matamoros",{"type":44,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100503374","omic-technologies-applied-to-the-study-of-b-cell-lymphoma-for-the-discovery-of-diagnostic-and-prognosis-biomarkers-100503374",false,"NCT05834426","Omic Technologies Applied to the Study of B-cell Lymphoma for the Discovery of Diagnostic and Prognosis Biomarkers","Omic Technologies Applied to the Study of Diffuse Large B-cell Lymphoma and High-grade B-cell Lymphoma for the Discovery of Diagnostic and Prognosis Biomarkers","Inclusion Criteria:\n\n* 18 years and older;\n* Both sexes;\n* Patients with confirmed histopathological diagnosis of Diffuse Large B-cell Lymphoma and High-grade B-cell Lymphoma;\n* Eastern Cooperative Oncology Group (ECOG) performance status 0 to 2;\n* Patient intending to receive full-dose treatment (Monoclonal antibodies plus anthracycline based combination chemotherapy);\n* Staged with PET-CT or CT.\n\nExclusion Criteria:\n\n* Patients with comorbidities that may interfere with the interpretation of the results (CKD in dialysis phase, Autoimmune diseases, uncontrolled Diabetes Mellitus (DM), symptomatic Heart Failure (CHF), HIV positive, positive serology for hepatitis B and C);\n* Patients requiring multiple blood transfusions (4 or more blood components for the same period or cause);\n* Pregnant women;\n* First-line treatment in another institution;\n* Diffuse transformed Diffuse Large B-cell Lymphoma and High-grade B-cell Lymphoma","ALL","18 Years",{"count":55,"type":56},50,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to determine the plasma metabolomic profile in diffuse large B-cell lymphoma and high-grade B lymphomas patients before, during and after treatment by ultra-high performance liquid chromatography with quadrupole time-of-flight mass spectrometry (UPLC-QTOFMS)",[60,61,62,63,64,65,66],"Lymphoma, B-Cell","Neoplasms","Cancer","High-grade B-cell Lymphoma","Diffuse Large B Cell Lymphoma","Non Hodgkin Lymphoma","Metabolomics",[68],"Metabolomic Analysis","NOT_YET_RECRUITING","2023-06-19",{"date":72,"type":73},"2023-06-22","ACTUAL",{"date":75,"type":56},"2023-09-01",{"date":77,"type":56},"2026-08-31",{"name":5,"class":6},1]