[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100611017":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":12,"locations":21,"responsibleParty":39,"collaborators":41,"id":44,"slug":45,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":46,"sex":51,"minAge":52,"maxAge":10,"enrollmentInfo":53,"targetDuration":10,"studyType":56,"phases":10,"briefSummary":57,"conditions":58,"keywords":65,"overallStatus":23,"whyStopped":10,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"Ospedale Policlinico San Martino","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Patients diagnosed with neurodegenerative diseases",null,"The study aims to identify pathogenic genomic variants and\u002For altered molecular pathways in these patients by analysing the entire genome and integrating these data with gene expression data and\u002For epigenomic and\u002For protein expression data. The study also aims to identify new markers for the diagnosis and monitoring of neurodegenerative diseases by analysing collected biological samples such as blood and blood derivatives, including liquid biopsy approaches using the most advanced technologies available at the t",[13,18],{"name":14,"role":15,"phone":16,"phoneExt":10,"email":17},"Paola Mandich, MD, PhD","CONTACT","+39 3473051001","paola.mandich@unige.it",{"name":19,"role":15,"phone":10,"phoneExt":10,"email":20},"Vittorio Bocchini, Dr","vittorio.bocchini@hsanmartino.it",[22],{"facility":5,"status":23,"city":24,"state":24,"zip":25,"country":26,"countryCode":27,"cosmosGeoPoint":28,"geoPoint":33,"contacts":34},"RECRUITING","Genoa","16132","Italy","IT",{"type":29,"coordinates":30},"Point",[31,32],8.94439,44.40478,{"lat":32,"lon":31},[35],{"name":36,"role":15,"phone":37,"phoneExt":10,"email":38},"Paola Mandich, MD","0103537957","paola.mandich@unige.it; pmandich@unige.it",{"type":40,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[42],{"name":43,"class":6},"Istituto Italiano di Tecnologia","100611017","omics-sciences-for-the-identification-of-pathogenetic-mechanisms-and-biomarkers-in-neurodegenerative-diseases-100611017",false,"NCT07235111","Omics Sciences for the Identification of Pathogenetic Mechanisms and Biomarkers in Neurodegenerative Diseases","NeurOmics","Inclusion Criteria\n\n• Patients suffering from neurodegenerative diseases\n\nExclusion Criteria\n\n• Patients not suffering from neurodegenerative diseases","ALL","18 Years",{"count":54,"type":55},1200,"ESTIMATED","OBSERVATIONAL","The study aims to use 'omics' sciences, employing the most advanced technologies currently available, in order to identify pathogenic genomic variants, proteins and\u002For altered molecular pathways in neurodegenerative diseases and to obtain a new and more complete characterisation of subjects affected by the neurodegenerative diseases under study. Thanks to the integration of genomic, gene expression (transcriptomic and epigenomic), protein and metabolic data and clinical data, the study also aims to identify new markers for the diagnosis, prognosis, also in terms of response to therapy, and monitoring of neurodegenerative diseases.\n\nThe study involves the enrolment of at least 1.200 individuals with neurodegenerative disease.",[59,60,61,62,63,64],"Alzheimer Disease","FTD","Young-onset Dementia","MCI","Parkinson Disease","ALS (Amyotrophic Lateral Sclerosis)",[66,67,68,69,70,71],"LEWY BODIES DISEASE","young-onset dementia","alzheimer","parkinson","als","mci","2025-11-20",{"date":74,"type":75},"2025-11-25","ACTUAL",{"date":77,"type":75},"2025-02-28",{"date":79,"type":55},"2039-09-17",{"name":5,"class":6},1]