[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100624037":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":7,"centralContacts":8,"locations":7,"responsibleParty":18,"collaborators":7,"id":22,"slug":23,"hasResults":24,"nctId":25,"briefTitle":26,"officialTitle":27,"acronym":28,"eligibilityCriteria":29,"healthyVolunteers":24,"sex":30,"minAge":31,"maxAge":32,"enrollmentInfo":33,"targetDuration":7,"studyType":36,"phases":7,"briefSummary":37,"conditions":38,"keywords":40,"overallStatus":53,"whyStopped":7,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":7},{"fullName":5,"class":6},"University of Modena and Reggio Emilia","OTHER",null,[9,14],{"name":10,"role":11,"phone":12,"phoneExt":7,"email":13},"Roberto Tonelli, MD, PhD","CONTACT","0039059425934","rtonelli@unimore.it",{"name":15,"role":11,"phone":16,"phoneExt":7,"email":17},"Stefania Cerri, MD, PhD","00390594225335","stefania.cerri@unimore.it",{"type":19,"investigatorFullName":20,"investigatorTitle":21,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"PRINCIPAL_INVESTIGATOR","Roberto Tonelli","MD, PhD","100624037","open-ipf-observational-prediction-model-for-clinical-outcomes-in-idiopathic-pulmonary-fibrosis-100624037",false,"NCT07404423","OPEN-IPF: Observational Prediction modEl for cliNical Outcomes in Idiopathic Pulmonary Fibrosis","Observational Prediction Model for Clinical Outcomes in Idiopathic Pulmonary Fibrosis: a Multicentre, ML-driven Study (OPEN-IPF)","OPEN-IPF","Inclusion Criteria:\n\n* Age ≥18 years\n* Diagnosis of idiopathic pulmonary fibrosis established according to international guidelines and local multidisciplinary team (MDT) assessment\n* Availability of baseline clinical and functional data\n* Availability of follow-up data for at least 12 months, or until a clinically relevant event (e.g., death, lung transplantation)\n\nExclusion Criteria:\n\n* Interstitial lung disease other than IPF\n* Lung transplantation performed before the baseline (index) date\n* Absence of any follow-up information after baseline","ALL","18 Years","90 Years",{"count":34,"type":35},1000,"ESTIMATED","OBSERVATIONAL","Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with marked inter-individual heterogeneity in trajectories and outcomes. Despite antifibrotic therapies, reliable risk stratification in routine practice remains suboptimal. OPEN-IPF is a multicentre retrospective observational cohort study designed to build a harmonised real-world dataset across Italian IPF referral centres to enable the development and external validation of machine-learning (ML) models predicting clinically relevant outcomes.",[39],"Idiopathic Pulmonary Fibrosis",[41,42,43,44,45,46,47,48,49,50,51,52],"Idiopathic pulmonary fibrosis","IPF","Disease progression","Acute exacerbation","Antifibrotic therapy","Nintedanib","Pirfenidone","Real-world data","Machine learning","Prognostic model","External validation","Multicentre cohort","NOT_YET_RECRUITING","2026-02-04",{"date":56,"type":57},"2026-02-11","ACTUAL",{"date":59,"type":35},"2026-06-01",{"date":61,"type":35},"2027-06-01",{"name":5,"class":6}]