[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100608495":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":30,"locations":36,"responsibleParty":53,"collaborators":25,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":25,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":25,"maxAge":25,"enrollmentInfo":65,"targetDuration":25,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":25,"overallStatus":38,"whyStopped":25,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"Mansoura University Children Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group 1 (intervention group)","EXPERIMENTAL","Group I (Intervention group): Fifty five preterm infants with direct weaning from HFOV (high frequency oscillatory ventilation) to CPAP (continuous positive airway pressure).",[13],"Other: HFOV weaning protocol 1",{"label":15,"type":16,"description":17,"interventionNames":18},"Group II (Control group)","ACTIVE_COMPARATOR","Group II (Control group): Fifty five preterm infants with weaning from HFOV (high frequency oscillatory ventilation) to conventional mechanical ventilation (CMV) then to CPAP (continuous positive airway pressure) .",[19],"Other: HFOV weaning protocol 2",[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"HFOV weaning protocol 1","weaning preterm neonates with RDS from HFOV directly to CPAP",[9],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"HFOV weaning protocol 2","weaning of preterm neonates with RDS to CMV then to CPAP",[15],[31],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Yasmina E Keshta","CONTACT","+201010166023","yasminakeshta@mans.edu.eg",[37],{"facility":5,"status":38,"city":39,"state":25,"zip":25,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"RECRUITING","Al Mansurah","Egypt","EG",{"type":43,"coordinates":44},"Point",[45,46],31.38069,31.03637,{"lat":46,"lon":45},[49],{"name":50,"role":33,"phone":51,"phoneExt":25,"email":52},"Basma O Shouman","+201001550144","boshouman@mans.edu.eg",{"type":54,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Yasmina Elsaied Hassan Keshta","assistant lecturer of pediatrics","100608495","open-label-randomized-controlled-trial-of-two-protocols-for-weaning-from-high-frequency-oscillatory-ventilation-in-preterm-neonates-with-respiratory-distress-syndrome-admitted-in-the-nicu-of-mansoura-university-children-hospital-100608495",false,"NCT07202299","Open-label Randomized Controlled Trial of Two Protocols for Weaning From High Frequency Oscillatory Ventilation in Preterm Neonates With Respiratory Distress Syndrome Admitted in the NICU of Mansoura University Children Hospital","Randomized Controlled Trial of Two Protocols for Weaning From High Frequency Oscillatory Ventilation in Preterm Neonates With Respiratory Distress Syndrome","Inclusion Criteria:\n\n* Preterm infants with RDS whose gestational age is 34 weeks or less who required HFOV for more than 24 hours duration due to failure of non- invasive respiratory support due to any of the following:\n\n  1. Severe hypercapnea PaCO2 \\> 60 mmHg associated with pH \\\u003C 7.25.\n  2. Hypoxemia PaO2 \\\u003C 50 mmHg, with FiO2 \\> 40%.\n  3. Frequent apneas: 6 or more episodes of apnea requiring mild or moderate stimulation within 6-hour period or one apneic episode requiring bag and mask positive pressure ventilation.\n\nExclusion Criteria:\n\nPreterm infants with any of the following :\n\n1. Major congenital malformations or chromosomal aberrations.\n2. Inborn errors of metabolism.\n3. Severe intraventricular hemorrhage (IVH) grade III or IV","ALL",{"count":66,"type":67},110,"ESTIMATED","INTERVENTIONAL",[70],"NA","Our study is a randomized controlled trial that compares two weaning protocols of preterm infants with respiratory distress syndrome who are ventilated on high frequency oscillatory ventilation in order to establish the best weaning strategy with the least complications possible for this group of patients.",[73],"Respiratory Distress Syndrome (Neonatal)","2025-09-23",{"date":76,"type":77},"2025-10-01","ACTUAL",{"date":79,"type":77},"2025-09-22",{"date":81,"type":67},"2027-09",{"name":5,"class":6},1]