[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100538848":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":33,"locations":41,"responsibleParty":125,"collaborators":127,"id":136,"slug":137,"hasResults":138,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":142,"eligibilityCriteria":143,"healthyVolunteers":138,"sex":144,"minAge":145,"maxAge":25,"enrollmentInfo":146,"targetDuration":25,"studyType":149,"phases":150,"briefSummary":152,"conditions":153,"keywords":25,"overallStatus":69,"whyStopped":25,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":168},{"fullName":5,"class":6},"Centre hospitalier de l'Université de Montréal (CHUM)","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Open lung extubation","EXPERIMENTAL","At the beginning of emergence, patients will be positioned with the head of the bed elevated to at least 30 degrees and the FiO2 will be set at 50%. At the resumption of spontaneous ventilation or earlier at the discretion of the anesthesiologist, the ventilator will be set to pressure support ventilation mode for the rest of the emergence procedure. The pressure support level will be adjusted to obtain a volume similar to the one used prior to emergence. PEEP will be left unchanged. Anesthesiologists will be instructed not to switch off the ventilator until the patient is extubated.",[13],"Other: Protective \"open-lung\" extubation",{"label":15,"type":16,"description":17,"interventionNames":18},"Conventional extubation","ACTIVE_COMPARATOR","At the beginning of emergence, patients will be positioned in a dorsal decubitus position and the FiO2 will be set at 100%. At the resumption of spontaneous ventilation or earlier at the discretion of the anesthesiologist, the ventilator will be switched off for the rest of the emergence procedure with the adjustable pressure-limiting valve open to atmosphere. Manual ventilation or assistance will be allowed, but the adjustable pressure-limiting valve will be reopened when pausing manual ventilation or assistance.",[19],"Other: Conventional extubation",[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Protective \"open-lung\" extubation","Emergence using 50% FiO2, semi-sitting position with pressure support ventilation and preserved PEEP",[9],null,{"type":6,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"Emergence using 100% FiO2, dorsal decubitus position with assistance or manual bag ventilation without PEEP",[15],[30],{"name":31,"affiliation":5,"role":32},"Martin Girard, MD","PRINCIPAL_INVESTIGATOR",[34,38],{"name":31,"role":35,"phone":36,"phoneExt":25,"email":37},"CONTACT","514-890-8000","martin.girard@umontreal.ca",{"name":39,"role":35,"phone":36,"phoneExt":25,"email":40},"Eva Amzallag, MSC","eva.amzallag.chum@ssss.gouv.qc.ca",[42,67,87,104],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"The Ottawa Hospital","NOT_YET_RECRUITING","Ottawa","Ontario","K1H 8L6","Canada","CA",{"type":51,"coordinates":52},"Point",[53,54],-75.69812,45.41117,{"lat":54,"lon":53},[57,61,64,65],{"name":58,"role":35,"phone":59,"phoneExt":25,"email":60},"Daniel I. McIsaac, MD","613-761-4940","dmcisaac@toh.ca",{"name":62,"role":35,"phone":25,"phoneExt":25,"email":63},"Manoj Lalu, MD","mlalu@toh.ca",{"name":58,"role":32,"phone":25,"phoneExt":25,"email":25},{"name":62,"role":66,"phone":25,"phoneExt":25,"email":25},"SUB_INVESTIGATOR",{"facility":68,"status":69,"city":70,"state":46,"zip":71,"country":48,"countryCode":49,"cosmosGeoPoint":72,"geoPoint":76,"contacts":77},"Unity Health Network","RECRUITING","Toronto","M5B 1W8",{"type":51,"coordinates":73},[74,75],-79.39864,43.70643,{"lat":75,"lon":74},[78,82,85,86],{"name":79,"role":35,"phone":80,"phoneExt":25,"email":81},"Michael C. Sklar, MD","416-864-5071","michael.sklar@mail.utoronto.ca",{"name":83,"role":35,"phone":25,"phoneExt":25,"email":84},"Ashwin Sankar, MD","ashwin.sankar@mail.utoronto.ca",{"name":79,"role":32,"phone":25,"phoneExt":25,"email":25},{"name":83,"role":66,"phone":25,"phoneExt":25,"email":25},{"facility":88,"status":69,"city":89,"state":90,"zip":91,"country":48,"countryCode":49,"cosmosGeoPoint":92,"geoPoint":96,"contacts":97},"Centre Hospitalier de l'Université de Montréal (CHUM)","Montreal","Quebec","H2X 0C1",{"type":51,"coordinates":93},[94,95],-73.58781,45.50884,{"lat":95,"lon":94},[98,99,100,102],{"name":31,"role":35,"phone":36,"phoneExt":25,"email":37},{"name":39,"role":35,"phone":36,"phoneExt":25,"email":40},{"name":101,"role":66,"phone":25,"phoneExt":25,"email":25},"Michael Chassé, MD",{"name":103,"role":66,"phone":25,"phoneExt":25,"email":25},"François Martin Carrier, MD",{"facility":105,"status":69,"city":106,"state":90,"zip":107,"country":48,"countryCode":49,"cosmosGeoPoint":108,"geoPoint":112,"contacts":113},"CHU de Québec - Université Laval","Québec","G1V 4G2",{"type":51,"coordinates":109},[110,111],-71.21454,46.81228,{"lat":111,"lon":110},[114,119,123,124],{"name":115,"role":35,"phone":116,"phoneExt":117,"email":118},"Alexis F. Turgeon, MD","418-525-4444","66058","alexis.turgeon@fmed.ulaval.ca",{"name":120,"role":35,"phone":116,"phoneExt":121,"email":122},"Michael Verret, MD","66847","michael.verret.med@ssss.gouv.qc.ca",{"name":115,"role":32,"phone":25,"phoneExt":25,"email":25},{"name":120,"role":66,"phone":25,"phoneExt":25,"email":25},{"type":126,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[128,130,131,133],{"name":129,"class":6},"CHU de Quebec-Universite Laval",{"name":43,"class":6},{"name":132,"class":6},"University Health Network, Toronto",{"name":134,"class":135},"Canadian Institutes of Health Research (CIHR)","OTHER_GOV","100538848","open-lung-protective-extubation-following-general-anesthesia-100538848",false,"NCT06296173","Open Lung Protective Extubation Following General Anesthesia","Open Lung Protective Extubation Following General Anesthesia: the OLEXT-3 Trial","OLEXT-3","Inclusion Criteria:\n\n* Adult patients (18 years of age or over)\n* Elective intra-abdominal surgery under general anesthesia.\n* Moderate or high risk of postoperative pulmonary complication according to the ARISCAT score (score of 26 or more)\n* Planned postoperative hospitalization\n\nExclusion Criteria:\n\n* Expected or known difficult intubation according to the treating anesthesiologist\n* Postoperative mechanical ventilation (planned or unplanned)\n* General anesthesia performed outside the main operating room","ALL","18 Years",{"count":147,"type":148},270,"ESTIMATED","INTERVENTIONAL",[151],"NA","Perioperative respiratory complications are a major source of morbidity and mortality. Postoperative atelectasis plays a central role in their development. Protective \"open lung\" mechanical ventilation aims to minimize the occurrence of atelectasis during the perioperative period. Randomized controlled studies have been performed comparing various \"open lung\" ventilation protocols, but these studies report varying and conflicting effects. The interpretation of these studies is complicated by the absence of imagery supporting the pulmonary impact associated with the use of different ventilation strategies. Imaging studies suggest that the gain in pulmonary gas content in \"open lung\" ventilation regimens disappears within minutes after the extubation. Thus, the potential benefits of open-lung ventilation appear to be lost if, at the time of extubation, no measures are used to keep the lungs well aerated. Recent expert recommendations on good mechanical ventilation practices in the operating room conclude that there is actually no quality study on extubation.\n\nExtubation is a very common practice for anesthesiologists as part of their daily clinical practice. It is therefore imperative to generate evidence on good clinical practice during anesthetic emergence in order to potentially identify an effective extubation strategy to reduce postoperative pulmonary complications.",[154,155,156,157,158],"Intra-abdominal Surgery","Anesthesia","Lung Injury","Ventilator-Induced Lung Injury","Atelectasis","2026-01-19",{"date":161,"type":162},"2026-01-21","ACTUAL",{"date":164,"type":162},"2024-10-08",{"date":166,"type":148},"2027-04-01",{"name":5,"class":6},4]