[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100638263":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":35,"centralContacts":36,"locations":42,"responsibleParty":54,"collaborators":35,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":60,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":35,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":81,"overallStatus":83,"whyStopped":35,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Clinical Centre of Serbia","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Opioid-Free Anesthesia Groupe","EXPERIMENTAL","Patients in the opioid-free group will receive anesthesia without any opioids.",[13],"Procedure: Opioid Free Anaesthesia",{"label":15,"type":16,"description":17,"interventionNames":18},"Opioid anesthesia groupe","ACTIVE_COMPARATOR","In the opioid group, patients will receive conventional opioid-based anesthesia.",[19],"Procedure: Opioid Anesthesia",[21,29],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Opioid Free Anaesthesia","Anesthesia will consist of a multimodal combination of general non-opioid agents (propofol, dexmedetomidine, midazolam, sevoflurane, and esketamine) supplemented by regional anesthesia techniques, including the erector spinae plane block (ESPB), serratus anterior plane block, and parasternal block.",[9],[27,28],"Opioid-free","Anesthesia",{"type":22,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"Opioid Anesthesia","This will include intraoperative opioids (e.g., fentanyl or sufentanil) in combination with general anesthetic agents such as propofol, sevoflurane, and midazolam, supplemented by additional analgesics as required. Regional anesthesia techniques (e.g., erector spinae plane block, serratus anterior plane block, or parasternal block) may also be performed at the discretion of the attending anesthesiologist",[15],[34],"sufentanil",null,[37],{"name":38,"role":39,"phone":40,"phoneExt":35,"email":41},"Dejan Markovic, MD, PhD, Associated Professor","CONTACT","+381668300903","drdejanmarkovic@gmail.com",[43],{"facility":44,"status":35,"city":45,"state":35,"zip":35,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":35},"Clinical Center of Serbia","Belgrade","Serbia","RS",{"type":49,"coordinates":50},"Point",[51,52],20.46513,44.80401,{"lat":52,"lon":51},{"type":55,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":35,"oldOrganization":35},"PRINCIPAL_INVESTIGATOR","Dejan Markovic","MD, PhD, Associate Professor","100638263","opioid-free-anesthesia-and-pain-study-in-cardiac-surgery-patients-100638263",false,"NCT07618130","Opioid-Free Anesthesia and Pain Study in Cardiac Surgery Patients","Assessment od the Effects of Opioid-Free Anesthesia on Acute and Chronich Postsurgical Pain in Cardiac Surgery Patinets: A Prospective Randomized Controlled Trial","OFPAINS-CS","Inclusion Criteria:\n\n* elective cardiac surgery patients\n\nExclusion Criteria:\n\n* Emergecy cardiac surgery patients","ALL","18 Years","99 Years",{"count":70,"type":71},400,"ESTIMATED","INTERVENTIONAL",[74],"NA","The goal of this clinical trial is to compare the effect of opioid-free anesthesia on the intensity of acute and chronic postoperative pain in patients undergoing cardiac surgery. The study will also evaluate the safety of opioid-free anesthesia in this patient population.\n\nThe main questions it aims to answer are:\n\n* Is opioid-free anesthesia effective in reducing the intensity of acute and chronic postoperative pain in cardiac surgery patients?\n* Is this anesthetic technique safe in this patient population? Patients will be randomized before surgery into two groups. In the first group, anesthesia will be performed with opioids, while in the second group, anesthesia will be performed without opioids. Researchers will measure acute postoperative pain during the first 48 hours using the Numeric Rating Pain Scale (NRPS). Chronic postoperative pain will be assessed after 3 months via a telephone interview.\n\nAdditionally, the incidence of adverse events-including postoperative delirium (POD), hemodynamic instability, respiratory complications, constipation, and postoperative nausea and vomiting (PONV)-as well as overall treatment outcomes, will be evaluated.",[77,78,79,80],"Posoperativ Pain","Chronich Pain","Postoperativ Delirum","Opoid-free Managment",[82],"OPIOPID-FREE, ANESTHESIA, CARDIAC SURGERY, ACUT PAIN, CHRONICH PAIN, POD","NOT_YET_RECRUITING","2026-05-24",{"date":86,"type":87},"2026-06-01","ACTUAL",{"date":89,"type":71},"2026-07-01",{"date":91,"type":71},"2027-11-20",{"name":5,"class":6},1]