[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100581132":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":10,"locations":10,"responsibleParty":15,"collaborators":10,"id":19,"slug":20,"hasResults":21,"nctId":22,"briefTitle":23,"officialTitle":24,"acronym":10,"eligibilityCriteria":25,"healthyVolunteers":21,"sex":26,"minAge":27,"maxAge":10,"enrollmentInfo":28,"targetDuration":31,"studyType":32,"phases":10,"briefSummary":33,"conditions":34,"keywords":10,"overallStatus":37,"whyStopped":10,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":10},{"fullName":5,"class":6},"Selcuk University","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Opioid-Based Anesthesia (Group 1)",null,"Group I patients underwent induction with propofol (2.0 mg\u002Fkg), fentanyl (2 µg\u002Fkg), and rocuronium (0.6 mg\u002Fkg). Maintenance of anesthesia was achieved using remifentanil (0.1-0.25 µg\u002Fkg\u002Fmin), titrated to maintain a BIS level of 40-60, and the inhalation anesthetic agent sevoflurane, targeting a MAC of 1.0-1.5. No external intervention was made regarding drug dosages",{"label":13,"type":10,"description":14,"interventionNames":10},"Opioid-Free Anesthesia (Group 2)","Group II patients underwent induction with propofol (2.0 mg\u002Fkg), ketamine (0.3 mg\u002Fkg), and rocuronium (0.6 mg\u002Fkg). Maintenance of anesthesia was achieved using ketamine (10-45 µg\u002Fkg\u002Fmin), titrated to maintain a BIS level of 40-60, and sevoflurane, targeting a MAC of 1.0-1.5. In Group II, the ketamine infusion was discontinued 30 minutes before the end of the surgery. No external intervention was made regarding drug dosages.",{"type":16,"investigatorFullName":17,"investigatorTitle":18,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Meltem Mavuş","MD","100581132","opioid-free-anesthesia-and-quality-of-recovery-after-general-anesthesia-100581132",false,"NCT06846333","Opioid-free Anesthesia and Quality of Recovery After General Anesthesia","Effect of Opioid-free Anesthesia Protocol on Quality of Recovery After Major Surgery in Geriatric Patients","Inclusion Criteria:\n\n* Patients aged 65 and older\n* Undergoing major elective non-cardiac surgery under general anesthesia\n* Classified as ASA I-II-III\n* With sufficient cognitive ability to complete a questionnaire were included in the study\n\nExclusion Criteria:\n\n* Patients requiring rapid sequence induction for emergency cases\n* Those with severe psychiatric or cognitive disorders preventing questionnaire evaluation\n* A body mass index \\\u003C 18 or \\> 39 kg\u002Fm²\n* Allergy or contraindication to any drug included in the study\n* A history of chronic pain or chronic opioid use\n* Uncontrolled epilepsy, decompensated heart failure\n* Chronic kidney or liver failure\n* Preoperative bradycardia with atrioventricular block (2nd or 3rd degree)\n* Heart rate \\\u003C 50 bpm due to chronic beta-blocker therapy\n* Those using medications that prolong the QT interval\n* Patients whose anesthesia regimen was intraoperatively changed (from opioid-free to opioid-containing anesthesia)","ALL","65 Years",{"count":29,"type":30},60,"ESTIMATED","3 Days","OBSERVATIONAL","This study aimed to evaluate the effect of an opioid-free anesthesia protocol on postoperative recovery quality in patients aged 65 years and older undergoing major surgery. Recovery quality was assessed using the Quality of Recovery-15 (QoR-15) questionnaire. Findings are expected to contribute to optimizing anesthesia practices in the elderly population by improving recovery quality and reducing opioid-related side effects.",[35,36],"Opioid-free Anesthesia","Geriatric Population","NOT_YET_RECRUITING","2025-02-25",{"date":40,"type":41},"2025-02-26","ACTUAL",{"date":43,"type":30},"2025-02-20",{"date":45,"type":30},"2025-04-30",{"name":5,"class":6}]