[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100618935":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":21,"locations":30,"responsibleParty":43,"collaborators":45,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":53,"sex":58,"minAge":10,"maxAge":10,"enrollmentInfo":59,"targetDuration":62,"studyType":63,"phases":10,"briefSummary":64,"conditions":65,"keywords":10,"overallStatus":68,"whyStopped":10,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},{"fullName":5,"class":6},"EPC Education s.r.o.","OTHER",[8,12,15,18],{"label":9,"type":10,"description":11,"interventionNames":10},"Group 1",null,"Tramadol Cohort",{"label":13,"type":10,"description":14,"interventionNames":10},"Group 2","Tapentadol Cohort",{"label":16,"type":10,"description":17,"interventionNames":10},"Group 3","Buprenorphine - Morphin Cohort",{"label":19,"type":10,"description":20,"interventionNames":10},"Group 4","Fentanyl Cohort",[22,27],{"name":23,"role":24,"phone":25,"phoneExt":10,"email":26},"Ladislav Kocan, assoc. Prof MD","CONTACT","00421557891100","europainclinicsstudy@mail.com",{"name":28,"role":24,"phone":10,"phoneExt":10,"email":29},"Janka Vaskova, Prof. Dr. PhD.","janka.vaskova@upjs.sk",[31],{"facility":32,"status":10,"city":33,"state":10,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":10},"University of Pavol JoSef Safarik","Košice","04011","Slovakia","SK",{"type":38,"coordinates":39},"Point",[40,41],21.25802,48.71441,{"lat":41,"lon":40},{"type":44,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[46,48],{"name":47,"class":6},"Pavol Jozef Safarik University",{"name":49,"class":50},"F.D.Roosevelt Banska Bystrica Slovak Republic","UNKNOWN","100618935","opioidredoxstudyii-100618935",false,"NCT07338084","OpioidRedoxStudyII","ORRS","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Receiving opioid therapy (tramadol, tapentadol, morphine, fentanyl, or buprenorphine) as part of routine clinical care\n* Stable opioid treatment for at least a predefined minimum period prior to enrollment (according to the study protocol)\n* Ability to provide written informed consent\n* Ability to comply with study procedures, including blood sampling and completion of questionnaires\n\nExclusion Criteria:\n\n* Acute opioid intoxication or withdrawal at the time of enrollment\n* Use of investigational drugs or participation in another interventional clinical trial that could interfere with study outcomes\n* Severe acute illness or unstable medical condition that, in the investigator's judgment, would interfere with study participation\n* Known pregnancy or breastfeeding\n* Inability to provide informed consent\n* Any condition that, in the opinion of the investigator, would make participation unsafe or compromise the quality of the collected data","ALL",{"count":60,"type":61},120,"ESTIMATED","3 Years","OBSERVATIONAL","This observational study aims to examine the relationship between opioid use and redox balance in adults. Redox balance reflects the level of oxidative stress in the body, which is known to play an important role in many biological processes and diseases.\n\nParticipants who use opioids will be included in the study. No experimental treatment or changes to current medical care will be provided as part of this study. Biological samples may be collected to assess redox-related biomarkers, and relevant clinical and demographic information will be recorded.\n\nThe results of this study are expected to improve understanding of how opioid exposure is associated with redox balance in adults. This information may help inform future research on the biological effects of opioids and potential strategies to reduce harm associated with long-term opioid use.",[66,67],"Oxidative Stress","Opioid Use","NOT_YET_RECRUITING","2026-01-03",{"date":71,"type":72},"2026-01-13","ACTUAL",{"date":74,"type":61},"2026-06-30",{"date":76,"type":61},"2029-12-31",{"name":5,"class":6},1]