[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100641076":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":33,"centralContacts":34,"locations":40,"responsibleParty":64,"collaborators":33,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":33,"eligibilityCriteria":73,"healthyVolunteers":69,"sex":74,"minAge":75,"maxAge":33,"enrollmentInfo":76,"targetDuration":33,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":33,"overallStatus":55,"whyStopped":33,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Gangnam Severance Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Opiranserin+Acetaminophen group","EXPERIMENTAL","In the Opiranserin+Acetaminophen group, opiranserine 1000mg infusion will be provided over 10 hr. IV Acetaminophen 1g will be provided q 8h until 24 h potperatively.",[13],"Drug: Opiranserin+Acetaminophen",{"label":15,"type":16,"description":17,"interventionNames":18},"Acetaminophen+NSAIDs group","ACTIVE_COMPARATOR","In the Acetaminophen+NSAIDs group, Normal saline 500 ml will be provided over 10hr. IV Acetaminophen 1g and ibuprofen 300mg will be provided q 8h until 24 h potperatively.",[19],"Drug: Acetaminophen+NSAIDs",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Opiranserin+Acetaminophen","In the Opiranserin+Acetaminophen group, opiranserine 1000mg infusion will be provided over 10 hr. Opiranserin infusion will be started after the indduction of anesthesia. After laoding dose (160mg ) over 30 minutes, maintenace dose (840mg) will be infused over 9hr 30min. IV Acetaminophen 1g will be provided q 8h until 24 h potperatively.",[9],[27],"Arm I",{"type":22,"name":29,"description":17,"armGroupLabels":30,"otherNames":31},"Acetaminophen+NSAIDs",[15],[32],"Arm II",null,[35],{"name":36,"role":37,"phone":38,"phoneExt":33,"email":39},"Young Song","CONTACT","02-2019-6692","NEARMYHEART@yuhs.ac",[41,54],{"facility":5,"status":42,"city":43,"state":33,"zip":44,"country":45,"countryCode":33,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"NOT_YET_RECRUITING","Seoul","06273","South Korea",{"type":47,"coordinates":48},"Point",[49,50],126.9784,37.566,{"lat":50,"lon":49},[53],{"name":36,"role":37,"phone":33,"phoneExt":33,"email":33},{"facility":5,"status":55,"city":43,"state":33,"zip":44,"country":45,"countryCode":33,"cosmosGeoPoint":56,"geoPoint":58,"contacts":59},"RECRUITING",{"type":47,"coordinates":57},[49,50],{"lat":50,"lon":49},[60],{"name":61,"role":37,"phone":62,"phoneExt":33,"email":63},"Sun-Kyung Park","01024505924","mayskpark@gmail.com",{"type":65,"investigatorFullName":36,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":33,"oldOrganization":33},"PRINCIPAL_INVESTIGATOR","Professor","100641076","opiranserin-for-minimally-invasive-cholecystectomy-100641076",false,"NCT07620665","Opiranserin for Minimally Invasive Cholecystectomy","Comparison of Opiranserin\u002FAcetaminophen Versus Ibuprofen\u002FAcetaminophen for Postoperative Pain Management After Minimally Invasive Cholecystectomy: A Randomized, Controlled, Non-inferiority Trial","Inclusion Criteria:\n\n* Adult patient undergoing minimally invasive cholecystectomy\n\nExclusion Criteria:\n\n* Known hypersensitivity or allergy to acetaminophen, NSAIDs, opiranserin, or fentanyl.\n* pre-existing chronic pain,\n* clinically significant ECG findings (QRS \\> 200 msec, QTcF \\>450 msec)\n* severe renal impairment\n* severe hepatic impairment","ALL","19 Years",{"count":77,"type":78},88,"ESTIMATED","INTERVENTIONAL",[81],"NA","The purpose of this study is to evaluate whether the combination therapy of opiranserin and acetaminophen is non-inferior to the combination of non-steroidal anti-inflammatory drugs (NSAIDs) and acetaminophen for postoperative pain management after minimally invasive cholecystectomy.\n\nThis is a single-center, randomized, controlled, non-inferiority clinical trial in adult patients undergoing minimally invasive cholecystectomy. Participants will be randomly assigned to either the Treatement group (opiranserin + acetaminophen) or the control group (NSAIDs + acetaminophen) in a 1:1 ratio to compare the analgesic efficacy and safety between the two analgesic regimens.",[84,85],"Cholecystectomy, Laparoscopic","Cholecystectomy, Robotic","2026-06-16",{"date":88,"type":89},"2026-06-18","ACTUAL",{"date":91,"type":89},"2026-06-10",{"date":93,"type":78},"2028-05-30",{"name":5,"class":6},2]