[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100525475":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":26,"locations":35,"responsibleParty":56,"collaborators":25,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":25,"eligibilityCriteria":66,"healthyVolunteers":67,"sex":68,"minAge":69,"maxAge":25,"enrollmentInfo":70,"targetDuration":25,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":79,"overallStatus":38,"whyStopped":25,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Saint Thomas Hospital, Panama","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Pre-eclampsia","EXPERIMENTAL","Subjects admitted with severe pre-eclampsia, based on the criteria by the American College of Obstetricians and Gynecologists (ACOG)",[13],"Procedure: ONSD+AF",{"label":15,"type":16,"description":17,"interventionNames":18},"Control","ACTIVE_COMPARATOR","Subjects admitted for normal labor, without any criteria of pre-eclampsia",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","ONSD+AF","Measurement of the optic nerve sheath diameter and of sFLT-1\u002FPGIF index",[15,9],null,[27,32],{"name":28,"role":29,"phone":30,"phoneExt":25,"email":31},"Osvaldo Reyes, MD","CONTACT","+507 65655041","oreyespanama@yahoo.es",{"name":33,"role":29,"phone":25,"phoneExt":25,"email":34},"Adriana Martinz, MD","amartinzmd@gmail.com",[36],{"facility":37,"status":38,"city":39,"state":40,"zip":25,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Saint Thomas Hospital","RECRUITING","Panama City","Provincia de Panamá","Panama","PA",{"type":44,"coordinates":45},"Point",[46,47],-79.51973,8.9936,{"lat":47,"lon":46},[50,53],{"name":51,"role":29,"phone":52,"phoneExt":25,"email":31},"Osvaldo A Reyes, MD","o11(507)65655041",{"name":54,"role":29,"phone":25,"phoneExt":25,"email":55},"Lisseth Rodriguez, MD","lissyro29@gmail.com",{"type":57,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Osvaldo A. Reyes T.","Head of the research deparment","100525475","optic-nerve-sheath-measurement-and-angiogenic-factors-in-patients-with-pre-eclampsia-100525475",false,"NCT06122220","Optic Nerve Sheath Measurement and Angiogenic Factors in Patients With Pre-eclampsia.","Optic Nerve Sheath Measurement and Angiogenic Factors for the Diagnosis of Pre-eclampsia","Inclusion Criteria:\n\n* Pregnant women between 24 and 40 weeks of gestation.\n\nExclusion Criteria:\n\n* Multiple gestation\n* Maternal vasculitis\n* Previous cesarean section (3 or more)\n* Brain or eye tumors\n* Neurological conditions\n* Chronic renal disease\n* Purpura\n* Heart disease",true,"FEMALE","18 Years",{"count":71,"type":72},200,"ESTIMATED","INTERVENTIONAL",[75],"NA","Hypertensive disorders of pregnancy (HPT) are an important cause of maternal-feto-neonatal morbidity and mortality, being one of the three leading causes of maternal death in our country and in developing countries. The only cure for THE is termination of pregnancy, which ends up being a decision in which gestational age and maternal risks must be balanced. Angiogenic factors have come to occupy an indispensable place in the arsenal of tools that can be used to separate the patient with a high likelihood of complications from those in whom prolongation of pregnancy could represent an important neonatal benefit. Refining the diagnostic capability of this test would further improve maternal-fetal outcomes and the use of optic nerve sheath diameter (ONSD) measurement could make the difference.\n\nThe purpose of the present study is to correlate the measurement of ONSD with serum angiogenic factor (AF) values in patients with pre-eclampsia and to determine its predictive ability for adverse perinatal outcomes.",[78],"Pre-Eclampsia",[80,81,9],"Angiogenic factors","Optic nerve sheath diameter","2025-08-23",{"date":84,"type":85},"2025-08-26","ACTUAL",{"date":87,"type":85},"2025-08-15",{"date":89,"type":72},"2026-01-30",{"name":5,"class":6},1]