[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100615035":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":26,"locations":36,"responsibleParty":93,"collaborators":95,"id":100,"slug":101,"hasResults":102,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":106,"eligibilityCriteria":107,"healthyVolunteers":102,"sex":108,"minAge":109,"maxAge":18,"enrollmentInfo":110,"targetDuration":18,"studyType":113,"phases":114,"briefSummary":116,"conditions":117,"keywords":122,"overallStatus":132,"whyStopped":18,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":142},{"fullName":5,"class":6},"Maastricht University Medical Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"CPPopt treatment","EXPERIMENTAL","The CPPopt treatment group will receive management according to the Brain Trauma Foundation (BTF) guidelines, except for the targeted cerebral perfusion pressure. Here, the calculated \"optimal cerebral perfusion pressure (CPPopt)\" will be targeted, with updated CPPopt targets every 4 hours.",[13],"Other: Optimal cerebral perfusion pressure",{"label":15,"type":16,"description":17,"interventionNames":18},"Control group","NO_INTERVENTION","The intervention group will receive standard brain trauma management according to the Brain Trauma Foundation (BTF) guidelines, including the standard cerebral perfusion pressure target of 60-70 mmHg.",null,[20],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"Optimal cerebral perfusion pressure","The intervention group will receive CPPopt guided management with updated CPPopt targets every 4 hours. All other parameters will be handled according to Brain Trauma Foundation (BTF) guidelines.",[9],[25],"CPPopt",[27,32],{"name":28,"role":29,"phone":30,"phoneExt":18,"email":31},"Marcel Aries, dr.","CONTACT","0031-43-3876387","marcel.aries@mumc.nl",{"name":33,"role":29,"phone":34,"phoneExt":18,"email":35},"Rik Hendrix, dr.","0031-433874373","rik.hendrix@mumc.nl",[37,53,65,78],{"facility":38,"status":18,"city":39,"state":18,"zip":18,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Medisch Spectrum Twente","Enschede","Netherlands","NL",{"type":43,"coordinates":44},"Point",[45,46],6.89583,52.21833,{"lat":46,"lon":45},[49],{"name":50,"role":29,"phone":51,"phoneExt":18,"email":52},"Beishuizen, dr.","053 - 4872000","b.beishuizen@mst.nl",{"facility":54,"status":18,"city":55,"state":18,"zip":18,"country":40,"countryCode":41,"cosmosGeoPoint":56,"geoPoint":60,"contacts":61},"Maastricht Universitair Medisch Centrum+","Maastricht",{"type":43,"coordinates":57},[58,59],5.68889,50.84833,{"lat":59,"lon":58},[62,64],{"name":28,"role":29,"phone":63,"phoneExt":18,"email":31},"0031-434876583",{"name":33,"role":29,"phone":34,"phoneExt":18,"email":35},{"facility":66,"status":18,"city":67,"state":18,"zip":18,"country":40,"countryCode":41,"cosmosGeoPoint":68,"geoPoint":72,"contacts":73},"Radboud University Medical Center","Nijmegen",{"type":43,"coordinates":69},[70,71],5.85278,51.8425,{"lat":71,"lon":70},[74],{"name":75,"role":29,"phone":76,"phoneExt":18,"email":77},"Hoedemaekers, dr.","024 - 361727 3","Astrid.Hoedemaekers@radboudumc.nl",{"facility":79,"status":18,"city":80,"state":18,"zip":18,"country":40,"countryCode":41,"cosmosGeoPoint":81,"geoPoint":85,"contacts":86},"Haaglanden Medisch Centrum","The Hague",{"type":43,"coordinates":82},[83,84],4.29861,52.07667,{"lat":84,"lon":83},[87,91],{"name":88,"role":29,"phone":89,"phoneExt":18,"email":90},"Van Vliet, dr.","088 - 979 2119","p.van.vliet@haaglandenmc.nl",{"name":18,"role":29,"phone":18,"phoneExt":18,"email":92},"rik_h87@hotmail.com",{"type":94,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR",[96,97,98],{"name":38,"class":6},{"name":66,"class":6},{"name":99,"class":6},"Medical Center Haaglanden","100615035","optimal-cerebral-perfusion-pressure-guided-therapy-assessment-of-target-effectiveness---ii-100615035",false,"NCT07287358","Optimal Cerebral Perfusion Pressure Guided Therapy: Assessment of Target Effectiveness - II","CPPopt Guided Therapy: Assessment of Target Effectiveness - II","Cogitate II","Inclusion Criteria:\n\n* Adult (\\>18 years old)\n* Severe TBI requiring ICP-directed therapy for at least 24 hrs on the assessment of the recruiting intensive care team and\u002For attending neurosurgeon\n* Start randomization within 24 hrs after ICU admission.\n\nExclusion Criteria:\n\n* Known pregnancy\n* Moribund at presentation (e.g. bilaterally absent pupillary responses)\n* Patients with a primary decompressive craniectomy\n* Failure to get final written informed consent","ALL","18 Years",{"count":111,"type":112},60,"ESTIMATED","INTERVENTIONAL",[115],"NA","After severe traumatic brain injury, adequate blood flow to the brain is essential for recovery. This depends on arterial blood pressure, yet intensive care units apply fixed targets to all patients - treating every brain and patient the same. This study aims to change that. With new technology, 'optimal' blood pressure can be determined for each individual brain and treatment can be tailored accordingly. This personalized approach to neurocritical care has never been tested in a randomized controlled study before. If effective in showing reduced brain damage biomarkers, it will fundamentally transform brain injury treatment and dramatically improve recovery outcomes for patients worldwide.",[118,119,120,121],"Traumatic Brain Injury","Severe Traumatic Brain Injury","Intracranial Pressure","Cerebral Perfusion Pressure",[25,123,124,125,126,127,128,129,130,131],"optimal cerebral perfusion pressure","pressure reactivity index","PRx","Intracranial pressure","cerebral perfusion pressure","traumatic brain injury","severe traumatic brain injury","cogitate","cogitate-II","NOT_YET_RECRUITING","2025-12-31",{"date":135,"type":136},"2026-01-06","ACTUAL",{"date":138,"type":112},"2026-05-01",{"date":140,"type":112},"2028-05-15",{"name":5,"class":6},4]