[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100550312":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":28,"centralContacts":33,"locations":39,"responsibleParty":108,"collaborators":110,"id":114,"slug":115,"hasResults":116,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":120,"eligibilityCriteria":121,"healthyVolunteers":116,"sex":122,"minAge":123,"maxAge":124,"enrollmentInfo":125,"targetDuration":24,"studyType":128,"phases":129,"briefSummary":131,"conditions":132,"keywords":24,"overallStatus":42,"whyStopped":24,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":138,"completionDateStruct":140,"leadSponsor":142,"locationsCount":143},{"fullName":5,"class":6},"Medstar Health Research Institute","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"60 bpm, then 80 bpm","EXPERIMENTAL","Pacing rate of 60 bpm for the first 3 months, then switch to 80 bpm for the next 3 months.",[13,14],"Device: Pacing rate of 80 bpm","Device: Pacing rate of 60 bpm",{"label":16,"type":10,"description":17,"interventionNames":18},"80 bpm, then 60 bpm","Pacing rate of 80 bpm for the first 3 months, then switch to 60 bpm for the next 3 months.",[13,14],[20,25],{"type":21,"name":22,"description":22,"armGroupLabels":23,"otherNames":24},"DEVICE","Pacing rate of 80 bpm",[9,16],null,{"type":21,"name":26,"description":26,"armGroupLabels":27,"otherNames":24},"Pacing rate of 60 bpm",[9,16],[29],{"name":30,"affiliation":31,"role":32},"Athanasios Thomaides, MD","MedStar Health","PRINCIPAL_INVESTIGATOR",[34],{"name":35,"role":36,"phone":37,"phoneExt":24,"email":38},"Sarahfaye Dolman","CONTACT","302-530-1873","Sarahfaye.F.Dolman@medstar.net",[40,58,67,83,95],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"MedStar Georgetown University Hospital","RECRUITING","Washington D.C.","District of Columbia","20007","United States","US",{"type":49,"coordinates":50},"Point",[51,52],-77.03637,38.89511,{"lat":52,"lon":51},[55,57],{"name":35,"role":36,"phone":56,"phoneExt":24,"email":38},"3025301873",{"name":30,"role":36,"phone":24,"phoneExt":24,"email":24},{"facility":59,"status":42,"city":43,"state":44,"zip":60,"country":46,"countryCode":47,"cosmosGeoPoint":61,"geoPoint":63,"contacts":64},"MedStar Washington Hospital Center","20010",{"type":49,"coordinates":62},[51,52],{"lat":52,"lon":51},[65,66],{"name":35,"role":36,"phone":56,"phoneExt":24,"email":38},{"name":30,"role":36,"phone":24,"phoneExt":24,"email":24},{"facility":68,"status":69,"city":70,"state":71,"zip":72,"country":46,"countryCode":47,"cosmosGeoPoint":73,"geoPoint":77,"contacts":78},"MedStar Union Memorial Hospital","NOT_YET_RECRUITING","Baltimore","Maryland","21218",{"type":49,"coordinates":74},[75,76],-76.61219,39.29038,{"lat":76,"lon":75},[79,82],{"name":80,"role":36,"phone":37,"phoneExt":24,"email":81},"Sarahfaye Dolman, MPH","sarahfaye.f.dolman@medstar.net",{"name":30,"role":36,"phone":24,"phoneExt":24,"email":24},{"facility":84,"status":42,"city":85,"state":71,"zip":86,"country":46,"countryCode":47,"cosmosGeoPoint":87,"geoPoint":91,"contacts":92},"MedStar Southern Maryland Hospital","Clinton","20735",{"type":49,"coordinates":88},[89,90],-76.89831,38.76511,{"lat":90,"lon":89},[93,94],{"name":35,"role":36,"phone":56,"phoneExt":24,"email":38},{"name":30,"role":36,"phone":24,"phoneExt":24,"email":24},{"facility":96,"status":42,"city":97,"state":98,"zip":99,"country":46,"countryCode":47,"cosmosGeoPoint":100,"geoPoint":104,"contacts":105},"MedStar Heart and Vascular Office at Fairfax","Fairfax","Virginia","22031",{"type":49,"coordinates":101},[102,103],-77.30637,38.84622,{"lat":103,"lon":102},[106,107],{"name":35,"role":36,"phone":56,"phoneExt":24,"email":38},{"name":30,"role":36,"phone":24,"phoneExt":24,"email":24},{"type":109,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR",[111],{"name":112,"class":113},"Medtronic","INDUSTRY","100550312","optimal-pacing-rate-for-cardiac-resynchronization-therapy-100550312",false,"NCT06445439","Optimal Pacing Rate for Cardiac Resynchronization Therapy","Optimal Pacing Rate for Cardiac Resynchronization Therapy After Atrioventricular Node Ablation in Persistent Atrial Fibrillation and Heart Failure","OPT-RATE AF","Inclusion Criteria:\n\n1. Age 18 years or older\n2. History of persistent or permanent atrial fibrillation\n3. Implantation of CRT or conduction system pacing in prior 3 months to 5 years of study start\n4. History of intrinsic AVN block or have undergone AVN ablation in prior 3 months to 5 years of study start\n5. LVEF ≥ 50%\n6. N-terminal pro-B-type natriuretic peptide (NT-proBNP) \\>400 pg\u002FmL in the last 24 months\n7. Clinical HF diagnosis or NYHA class II or higher\n8. Able to provide informed consent\n\nExclusion Criteria:\n\n1. LVEF \\\u003C50%\n2. Wide QRS (greater than 150ms)\n3. Isolated RV pacing\n4. Severe valvular disease\n5. Severe coronary artery disease as defined by one of the following:\n\n   1. ACS or PCI within 1 year\n   2. Any angina (CCS class 1+)\n   3. Unrevascularizable severe CAD (\\>70% stenosis in 1+ major vessels and\u002For based on functional assessment)\n6. ESRD\n7. Significant primary pulmonary disease on home oxygen\n8. Major orthopedic issues, such as being wheelchair bound and\u002For unable to perform a six-minute walk test\n9. Ventricular ectopy \\>15% premature ventricular contractions (PVC)\n10. End stage cancer diagnosis\n11. Life expectancy less than one year\n12. Palliative or hospice care\n13. Hypertrophic cardiomyopathy (HCM)\n14. Uncorrected ventricular septal defect\n15. Infiltrative cardiomyopathy (CM)\n16. Uncontrolled hypertension as defined by blood pressure \\>160\u002F100 mm Hg on two measurements ≥15 minutes apart\n17. Hemoglobin \\\u003C7 g\u002FdL\n18. Age \\>90 years old\n19. Pregnant or intends to become pregnant","ALL","18 Years","90 Years",{"count":126,"type":127},60,"ESTIMATED","INTERVENTIONAL",[130],"NA","This is a prospective, randomized crossover study. The objective of the study is to determine if a pacing rate of 80 beats per minute (bpm) improves exercise tolerance during the 6-minute walk test. The investigators will randomly assign half of the participants to a starting rate of 60 bpm and then switch them to a rate of 80 bpm for 3 months, and vice versa.",[133],"Atrial Fibrillation, Persistent","2024-10-09",{"date":136,"type":137},"2024-10-15","ACTUAL",{"date":139,"type":137},"2023-12-19",{"date":141,"type":127},"2025-08",{"name":5,"class":6},5]