[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100626520":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":21,"locations":26,"responsibleParty":150,"collaborators":10,"id":152,"slug":153,"hasResults":154,"nctId":155,"briefTitle":156,"officialTitle":156,"acronym":157,"eligibilityCriteria":158,"healthyVolunteers":154,"sex":159,"minAge":160,"maxAge":10,"enrollmentInfo":161,"targetDuration":10,"studyType":164,"phases":10,"briefSummary":165,"conditions":166,"keywords":169,"overallStatus":29,"whyStopped":10,"lastUpdateSubmitDate":174,"lastUpdatePostDateStruct":175,"startDateStruct":178,"completionDateStruct":180,"leadSponsor":182,"locationsCount":183},{"fullName":5,"class":6},"Azienda ULSS 8 Berica","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Patients with intermediate-high or high-risk pulmonary embolism",null,"Patients with intermediate-high or high-risk pulmonary embolism stratified according to the ESC 2019 guidelines",[13,17],{"name":14,"affiliation":15,"role":16},"Marco Zuin, MD MS","Department of Translational Medicine, University of Ferrara, Italy","STUDY_DIRECTOR",{"name":18,"affiliation":19,"role":20},"Claudio Bilato, MD PhD","Department of Cardiology, Azienda AULSS 8 Berica, Arzignano (Vicenza), Italy","PRINCIPAL_INVESTIGATOR",[22],{"name":18,"role":23,"phone":24,"phoneExt":10,"email":25},"CONTACT","+390444479106","claudio.bilato@aulss8.veneto.it",[27,52,66,85,102,119,134],{"facility":28,"status":29,"city":30,"state":31,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"UO Unità di Cure Intensive Cardiologiche e Cardiologia 1, Ospedale Niguarda, Milano","RECRUITING","Milan","Milano","20162","Italy","IT",{"type":36,"coordinates":37},"Point",[38,39],12.59836,42.78235,{"lat":39,"lon":38},[42,46,47,50],{"name":43,"role":23,"phone":44,"phoneExt":10,"email":45},"Claudia Colombo, MD","+390264442565","claudia.colombo@ospealeniguarda.it",{"name":43,"role":20,"phone":10,"phoneExt":10,"email":10},{"name":48,"role":49,"phone":10,"phoneExt":10,"email":10},"Alice Sacco, MD","SUB_INVESTIGATOR",{"name":51,"role":49,"phone":10,"phoneExt":10,"email":10},"Fabrizio Oliva, MD",{"facility":53,"status":29,"city":54,"state":55,"zip":56,"country":33,"countryCode":34,"cosmosGeoPoint":57,"geoPoint":61,"contacts":62},"UOC di Cardiologia, Ospedali Riuniti Padova Sud, Monselice, Italia","Monselice","Padova","35043",{"type":36,"coordinates":58},[59,60],11.74984,45.239,{"lat":60,"lon":59},[63],{"name":14,"role":23,"phone":64,"phoneExt":10,"email":65},"+390429715631","marco.zuin@aulss6.veneto.it",{"facility":67,"status":29,"city":68,"state":68,"zip":69,"country":33,"countryCode":34,"cosmosGeoPoint":70,"geoPoint":74,"contacts":75},"IRCCS Policlinico San Matteo","Pavia","27100",{"type":36,"coordinates":71},[72,73],9.15917,45.19205,{"lat":73,"lon":72},[76,80,81,83],{"name":77,"role":23,"phone":78,"phoneExt":10,"email":79},"Leonardo De Luca, MD PhD","+390382503158","l.deluca@smatteo.pv.it",{"name":77,"role":20,"phone":10,"phoneExt":10,"email":10},{"name":82,"role":49,"phone":10,"phoneExt":10,"email":10},"Stefano Ghio, MD PhD",{"name":84,"role":49,"phone":10,"phoneExt":10,"email":10},"Guido Tavazzi, MD PhD",{"facility":86,"status":29,"city":87,"state":87,"zip":88,"country":33,"countryCode":34,"cosmosGeoPoint":89,"geoPoint":93,"contacts":94},"UO di Sezione di Medicina Interna e Cardiovascolare, Ospedale Santa Maria della Misericordia, Perugia, Italia","Perugia","06129",{"type":36,"coordinates":90},[91,92],12.38878,43.1122,{"lat":92,"lon":91},[95,99,101],{"name":96,"role":23,"phone":97,"phoneExt":10,"email":98},"Cecilia Becattini, MD PhD","+390755786424","cecilia.becattini@unipg.it",{"name":100,"role":49,"phone":10,"phoneExt":10,"email":10},"Maria Cristina Vedovati, MD PhD",{"name":96,"role":20,"phone":10,"phoneExt":10,"email":10},{"facility":103,"status":29,"city":104,"state":104,"zip":105,"country":33,"countryCode":34,"cosmosGeoPoint":106,"geoPoint":110,"contacts":111},"UO di Cardiologia 1, Azienda Ospedaliero Universitaria Pisana, Pisa, Italia","Pisa","56126",{"type":36,"coordinates":107},[108,109],10.4036,43.70853,{"lat":109,"lon":108},[112,116,117],{"name":113,"role":23,"phone":114,"phoneExt":10,"email":115},"Rosalinda Madonna, MD PhD","+39050996975","rosalinda.madonna@unipi.it",{"name":113,"role":20,"phone":10,"phoneExt":10,"email":10},{"name":118,"role":49,"phone":10,"phoneExt":10,"email":10},"Raffaele De Caterina, MD PhD",{"facility":120,"status":29,"city":121,"state":121,"zip":122,"country":33,"countryCode":34,"cosmosGeoPoint":123,"geoPoint":127,"contacts":128},"UO di Cardiologia, Azienda Ospedaliera Ordine Mauriziano di Torino","Torino","10128",{"type":36,"coordinates":124},[125,126],11.99138,44.88856,{"lat":126,"lon":125},[129,133],{"name":130,"role":23,"phone":131,"phoneExt":10,"email":132},"Giuseppe Musumeci, MD","+390115082515","giuseppe.musumeci@gmail.com",{"name":130,"role":20,"phone":10,"phoneExt":10,"email":10},{"facility":135,"status":29,"city":136,"state":137,"zip":138,"country":33,"countryCode":34,"cosmosGeoPoint":139,"geoPoint":143,"contacts":144},"UOC di Cardiologia, Ospedali dell'Ovest Vicentino, Arzignano, IItalia","Arzignano","Vicenza","36071",{"type":36,"coordinates":140},[141,142],11.33446,45.52027,{"lat":142,"lon":141},[145,147,148],{"name":18,"role":23,"phone":146,"phoneExt":10,"email":25},"+390444931163",{"name":18,"role":20,"phone":10,"phoneExt":10,"email":10},{"name":149,"role":49,"phone":10,"phoneExt":10,"email":10},"Chiara Dalla Valle, MD",{"type":151,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100626520","optimal-time-for-reperfusion-in-acute-pulmonary-embolism-100626520",false,"NCT07436702","Optimal Time for Reperfusion in Acute Pulmonary Embolism","OPTIRAPE","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Patients with a diagnosis of intermediate-high or high pulmonary embolism confirmed by computed tomography pulmonary angiography (CTPA), pulmonary angiography, or echocardiography (evidence of a floating thrombus in the right atrium or right ventricle, or proximal visualization of thrombus in the pulmonary artery).\n* Classified as high-risk or intermediate-high-risk according to the 2019 European Society of Cardiology guidelines.\n* Provision of informed consent for the processing of personal data.\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years\n* Patients in whom a diagnosis of acute high-risk or intermediate-high-risk pulmonary embolism has been excluded.\n* Inability to provide informed consent.","ALL","18 Years",{"count":162,"type":163},500,"ESTIMATED","OBSERVATIONAL","Pulmonary embolism (PE) is the third leading cause of cardiovascular mortality worldwide. Current guidelines recommend early reperfusion for high-risk and intermediate-high-risk PE, yet systemic thrombolysis and percutaneous therapies are frequently underutilized, and no specific timing for reperfusion is defined, unlike in acute myocardial infarction or ischemic stroke. As most PE-related in-hospital deaths occur within the first hours and thrombus composition changes over time, defining an optimal reperfusion time window may improve survival and prevent hemodynamic deterioration. We therefore propose a national, multicenter, prospective observational study to evaluate the prognostic impact of reperfusion timing, using systemic thrombolysis or catheter-directed therapies, on in-hospital mortality and haemorrhagic or cardiovascular complications.",[167,168],"Pulmonary Embolism (Diagnosis)","Pulmonary Embolism Acute",[170,171,172,173],"Fibrinolysis","Anticoagulation","Catheter-directed treatments","Time of Reperfusion","2026-03-01",{"date":176,"type":177},"2026-03-03","ACTUAL",{"date":179,"type":177},"2025-11-25",{"date":181,"type":163},"2026-10-30",{"name":5,"class":6},7]