[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100626046":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":19,"locations":20,"responsibleParty":32,"collaborators":19,"id":34,"slug":35,"hasResults":36,"nctId":37,"briefTitle":38,"officialTitle":39,"acronym":19,"eligibilityCriteria":40,"healthyVolunteers":36,"sex":41,"minAge":42,"maxAge":19,"enrollmentInfo":43,"targetDuration":19,"studyType":46,"phases":47,"briefSummary":49,"conditions":50,"keywords":53,"overallStatus":59,"whyStopped":19,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":69},{"fullName":5,"class":6},"University of Edinburgh","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Additional FIT testing","EXPERIMENTAL","Additional (3) FITs",[13],"Diagnostic Test: Additional FIT testing",[15],{"type":16,"name":9,"description":17,"armGroupLabels":18,"otherNames":19},"DIAGNOSTIC_TEST","Additional (3) FIT tests",[9],null,[21],{"facility":22,"status":19,"city":23,"state":19,"zip":19,"country":24,"countryCode":25,"cosmosGeoPoint":26,"geoPoint":31,"contacts":19},"NHS Lothian","Edinburgh","United Kingdom","UK",{"type":27,"coordinates":28},"Point",[29,30],-3.19648,55.95206,{"lat":30,"lon":29},{"type":33,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR","100626046","optimising-colorectal-cancer-patient-pathways-100626046",false,"NCT07430540","Optimising Colorectal Cancer Patient Pathways","Optimising Patient Pathways for Earlier Detection of Colorectal Cancer in Secondary Care: Implementation of Multiple FIT Testing","Inclusion Criteria:\n\n* Patients referred to the NHS Lothian USoC CRC pathway or an urgent referral with 'red-flag' symptoms, and with a positive FIT on referral will be included.\n* Referred from start date of study, for up to 1 year\n\nExclusion Criteria:\n\n* Two negative FITs on referral\n* Patients referred with a palpable rectal or abdominal mass\n* Previous history of CRC or IBD, or under polyp surveillance\n* Known to have genetic hereditary condition predisposing patient to increased risk of CRC (e.g. Lynch, FAP, etc).","ALL","18 Years",{"count":44,"type":45},1000,"ESTIMATED","INTERVENTIONAL",[48],"NA","Bowel cancer (colorectal cancer) is the 4th most common cancer in Scotland. Approximately 4,000 cases are diagnosed annually. Cancer-related deaths in Scotland are higher than other UK nations. Improving the early detection of bowel cancer, and therefore survival, is important.\n\nThe majority of bowel cancers are diagnosed within secondary-care (colorectal surgery unit). Upon GP referral to secondary-care, patients provide stool samples which are analysed for microscopic blood (FIT; faecal immunohistochemical test). Patients with a single positive result are more likely to have bowel cancer (0.2% risk if no blood detected, but 8.4% if detected). A positive test triggers further investigation, either CT scan or colonoscopy depending on the result. Currently, colonoscopy and radiology services throughout Scotland are under significant pressure causing delays.\n\nOnly 2% of patients referred to secondary-care are diagnosed with bowel cancer, and most colonoscopies performed do not yield significant findings. We have shown that performing two repeated FITs upon referral improves cancer pick-up rate (sensitivity) and reduces missed cancers. We successfully implemented this in NHS Lothian and contributed to national guidelines. Optimising allocation of investigations and therefore improving the detection-rate (specificity) may reduce colonoscopy demand, saving vital resources.\n\nNHS Lothian patients referred to secondary-care with symptoms concerning of bowel cancer will be included. \\~1,000 included patients will undertake extra FIT tests in study whether changes in stool blood levels over time help better allocate investigations and improve test specificity. With these results, a new secondary-care pathway will be designed. Health economic analysis will determine costs and benefits of implementing a new pathway and the risks of missed cancers. The project also provides infrastructure to collect additional stool and blood samples to develop new tests that improve bowel cancer detection.",[51,52],"Colorectal Cancer","Significant Bowel Pathology",[54,55,56,57,58],"colorectal cancer","Multiple testing","Diagnostic accuracy","Faecal Immunohistochemical Test","qFIT","NOT_YET_RECRUITING","2026-05-29",{"date":62,"type":63},"2026-06-03","ACTUAL",{"date":65,"type":45},"2026-06-30",{"date":67,"type":45},"2037-03-22",{"name":5,"class":6},1]