[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100584592":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":38,"centralContacts":42,"locations":52,"responsibleParty":75,"collaborators":78,"id":84,"slug":85,"hasResults":86,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":90,"eligibilityCriteria":91,"healthyVolunteers":86,"sex":92,"minAge":93,"maxAge":94,"enrollmentInfo":95,"targetDuration":30,"studyType":98,"phases":99,"briefSummary":101,"conditions":102,"keywords":107,"overallStatus":55,"whyStopped":30,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":121},{"fullName":5,"class":6},"Salk Institute for Biological Studies","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Dietary Monitoring","ACTIVE_COMPARATOR","Log all dietary intake and continue habitual eating patterns.",[13],"Behavioral: Dietary Monitoring",{"label":15,"type":16,"description":17,"interventionNames":18},"Time-Restricted Eating (TRE)","EXPERIMENTAL","Dietary Monitoring and adherence to a personalized consistent 10-hour time-restricted eating window",[19],"Behavioral: Time-Restricted Eating (TRE)",{"label":21,"type":16,"description":22,"interventionNames":23},"Time-Restricted Eating with Low-Glycemic Snack (TRE-LGS)","Dietary Monitoring and adherence to a modified personalized consistent 10-hour time-restricted eating window a low-glycemic snack provided by the research team to consume during night shifts.",[24],"Behavioral: Time-Restricted Eating with a Low-Glycemic Snack (TRE-LGS)",[26,31,34],{"type":27,"name":9,"description":28,"armGroupLabels":29,"otherNames":30},"BEHAVIORAL","Participants in the group will receive standard advice for a healthy lifestyle, log all food and beverage intake on the myCircadianClock app, and continue their habitual eating patterns.",[9],null,{"type":27,"name":15,"description":32,"armGroupLabels":33,"otherNames":30},"Participants in the group will receive standard advice for a healthy lifestyle, log all food and beverage intake on the myCircadianClock app, and adhere to a personalized consistent 10-hour time-restricted eating window.",[15],{"type":27,"name":35,"description":36,"armGroupLabels":37,"otherNames":30},"Time-Restricted Eating with a Low-Glycemic Snack (TRE-LGS)","Participants in the group will receive standard advice for a healthy lifestyle, log all food and beverage intake on the myCircadianClock app, and adhere to a personalized consistent 10-hour time-restricted eating window. On nights that participants work night shifts, they will consume a low-glycemic snack provided by the research team.",[21],[39],{"name":40,"affiliation":5,"role":41},"Emily Manoogian, Ph.D.","PRINCIPAL_INVESTIGATOR",[43,48],{"name":44,"role":45,"phone":46,"phoneExt":30,"email":47},"UCSD Study Coordinator","CONTACT","858-246-2342","research@mycircadianclock.org",{"name":49,"role":45,"phone":50,"phoneExt":51,"email":47},"Salk Clinical Researcher","858-453-4100","1077",[53],{"facility":54,"status":55,"city":56,"state":57,"zip":58,"country":59,"countryCode":60,"cosmosGeoPoint":61,"geoPoint":66,"contacts":67},"University of California San Diego Altman Clinical and Translational Research Institute","RECRUITING","La Jolla","California","92037","United States","US",{"type":62,"coordinates":63},"Point",[64,65],-117.2742,32.84727,{"lat":65,"lon":64},[68,69,70,73],{"name":44,"role":45,"phone":46,"phoneExt":30,"email":47},{"name":49,"role":45,"phone":50,"phoneExt":51,"email":47},{"name":71,"role":72,"phone":30,"phoneExt":30,"email":30},"Pam Taub, MD","SUB_INVESTIGATOR",{"name":74,"role":41,"phone":30,"phoneExt":30,"email":30},"Emily Manoogian, PhD",{"type":41,"investigatorFullName":76,"investigatorTitle":77,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"Emily N.C. Manoogian","Staff Scientist",[79,82],{"name":80,"class":81},"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","NIH",{"name":83,"class":6},"University of San Diego","100584592","optimization-of-chrononutrition-to-reduce-the-risk-of-disease-in-shift-workers-100584592",false,"NCT06891352","Optimization of Chrononutrition to Reduce the Risk of Disease in Shift Workers","Optimization of Chrononutrition to Reduce the Risk of Disease in Shift Workers - The SHIFT Study","SHIFT","Inclusion Criteria:\n\n* Age: 18-70 years\n* BMI ≥ 25 kg\u002Fm2 (or ≥ 23 kg\u002Fm2 for Asian adults)\n* Own a smartphone (Apple iOS or Android OS)\n* Baseline eating window ≥ 14 h\u002Fday\n* Night shift nurses and nursing assistants who are working a 12-hour night shift at least 3 days\u002Fweek.\n* Have been doing night shift work for at least 3 months.\n* Patients on cardiovascular medications (HMG CoA reductase inhibitors (statins), metformin, lipid-modifying drugs (including over-the-counter drugs such as red yeast rice and fish oil), anti-hypertensive, drugs), are allowed\n* If patients have Type 2 Diabetes, they will be included in the study if A1c is less than 9 and they are not on insulin.\n\nExclusion Criteria:\n\n* Insufficient dietary logging on the mCC app is defined as less than 7 of 14 days of baseline of dietary logging with a minimum of 2 items a day, at least 5 hours apart.\n* Type 1 Diabetes or Insulin-dependent Type 2 Diabetes.\n* Use of sulfonylurea or insulin within the last 3 months (due to unknown safety with TRE)\n* Use of medications that are known to cause weight loss such as SGLT2 inhibitors and GLP1 receptor agonists)\n* BMI \\> 50 kg\u002Fm2\n* Change in medications that could impact study outcomes within the past 3 months\n* Change in weight of \\>4kg in the past 3 months\n* Women who are pregnant, breastfeeding, or are trying to become pregnant during the study period. If a participant becomes pregnant during the study, they will be excluded from continuing the study.\n* Systolic BP greater than 160 mmHg and\u002For diastolic BP greater than 110 mmHg at rest\n* Fasting LDL cholesterol greater than 250 mg\u002FdL\n* Fasting triglycerides greater than 500g\u002FdL\n* Active tobacco abuse or illicit drug use or history of treatment for alcohol abuse in the past 5 years.\n* Frequent (more than 4) travel involving a time zone change of more than 3 hours over the 1-year study period\n* Prolonged leave from work (a continuous month or longer) during the study\n* Active treatment for inflammatory and\u002For rheumatologic disease\n* History of a major adverse cardiovascular event within the past year (acute coronary syndrome, percutaneous coronary intervention, coronary artery bypass graft surgery, hospitalization for congestive heart failure, stroke\u002Ftransient ischemic attack)\n* Uncontrolled arrhythmia (i.e. rate-controlled atrial fibrillation\u002Fatrial flutter are acceptable)\n* History of thyroid disease requiring dose titration of thyroid replacement medication(s) within the past 3 months (hypothyroidism on a stable dose of thyroid replacement therapy is allowed).\n* History of adrenal disease in the past 5 years\n* History of malignancy undergoing active treatment, except non-melanoma skin cancer, in the past 5 years\n* History of an eating disorder in the past 5 years\n* History of cirrhosis in the past 5 years\n* History of stage 4 or 5 chronic kidney disease or dialysis in the past 5 years\n* History of HIV\u002FAIDs\n* Currently enrolled in weight-loss or weight-management program\n* History of surgical intervention for weight management within the past 2 years, or longer if deemed unsafe following review by medical investigators\n* Uncontrolled psychiatric disorder including prior hospitalization","ALL","18 Years","70 Years",{"count":96,"type":97},180,"ESTIMATED","INTERVENTIONAL",[100],"NA","In this randomized controlled trial, the investigators will assess the health impacts of optimizing the timing of dietary consumption in nurses and nursing assistants who work night shifts, have a habitual eating window of 14 hours or more, and elevated weight. Participants will be randomized to one of three groups: (1) dietary monitoring, (2) dietary monitoring plus 10-hour daytime time-restricted eating (TRE), or (3) TRE with a low-glycemic snack during night shifts. The study includes a 2-week screening\u002Fbaseline health assessment, with follow-up health assessments at 3-, 6- (primary outcome), and 12 months.",[103,104,105,106],"Night Shift Work","Time Restricted Eating","Overweight","Obesity",[108,109,110,111],"Time-Restricted Eating","Night Shift work","Nurses","Nursing Assistants","2025-12-12",{"date":114,"type":115},"2025-12-17","ACTUAL",{"date":117,"type":115},"2025-06-02",{"date":119,"type":97},"2029-03-03",{"name":5,"class":6},1]