[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100391602":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":46,"responsibleParty":104,"collaborators":106,"id":110,"slug":111,"hasResults":112,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":26,"eligibilityCriteria":116,"healthyVolunteers":112,"sex":117,"minAge":118,"maxAge":119,"enrollmentInfo":120,"targetDuration":26,"studyType":123,"phases":124,"briefSummary":126,"conditions":127,"keywords":26,"overallStatus":49,"whyStopped":26,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":139},{"fullName":5,"class":6},"Case Western Reserve University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active (tDCS) + Active TUS","ACTIVE_COMPARATOR","Subjects in the experimental group will undergo 20 minutes of active transcranial direct current stimulation (tDCS) and active transcranial ultrasound (TUS)",[13],"Device: Active Comparator: Active tDCS + Active TUS",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham (tDCS) + Sham TUS","SHAM_COMPARATOR","Subjects in the sham group will undergo 20 minutes of sham transcranial direct current stimulation (tDCS) and sham transcranial ultrasound (TUS).",[19],"Device: Sham Comparator: Sham tDCS + Sham TUS",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Active Comparator: Active tDCS + Active TUS","Device: Active comparator device: Active transcranial Direct Current Stimulation (tDCS). Subjects will receive 20 minutes of active tDCS. During each Active stimulation session, stimulation will be applied for the full 20 minutes.\n\nDevice: Active comparator device: Active Transcranial Ultrasound (TUS). Subjects will receive 20 minutes of active Transcranial Ultrasound (TUS). During active stimulation the (TUS) will be active for the full 20 minutes.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Sham Comparator: Sham tDCS + Sham TUS","Device: SHAM Comparator Device: transcranial Direct Current Stimulation (tDCS) Subjects will receive 20 minutes of sham tDCS. In the sham group, the tDCS device will not be active for the full 20 minutes.\n\nDevice: Transcranial Ultrasound (TUS) Subjects will receive 20 minutes of sham TUS. During sham stimulation the ultrasound will not be active for the full 20 minutes.",[15],[32],{"name":33,"affiliation":34,"role":35},"Ciro R Estebanez, MD PhD","University Hospitals Cleveland Medical Center\u002F Case Western Reserve University","PRINCIPAL_INVESTIGATOR",[37,42],{"name":38,"role":39,"phone":40,"phoneExt":26,"email":41},"Kimberly Bass, RN","CONTACT","216-286-7250","kimberly.bass@uhhospitals.org",{"name":43,"role":39,"phone":44,"phoneExt":26,"email":45},"Mario Becerra, RN","216-844-1734","Mario.Becerra@UHHospitals.org",[47,69,87],{"facility":48,"status":49,"city":50,"state":51,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"University of Illinois Health\u002F University of Illinois at Chicago","RECRUITING","Hinsdale","Illinois","60612","United States","US",{"type":56,"coordinates":57},"Point",[58,59],-87.93701,41.80086,{"lat":59,"lon":58},[62,65,68],{"name":63,"role":39,"phone":26,"phoneExt":26,"email":64},"Ming-Chieh Shun, PhD","mshun@uic.edu",{"name":66,"role":39,"phone":26,"phoneExt":26,"email":67},"Ciro Ramos Estebanez, MD, PhD","cramoses@icloud.com",{"name":66,"role":35,"phone":26,"phoneExt":26,"email":26},{"facility":70,"status":49,"city":71,"state":72,"zip":73,"country":53,"countryCode":54,"cosmosGeoPoint":74,"geoPoint":78,"contacts":79},"Spaulding Rehabilitation Hospital - 5th Floor - Neuromodulation Center","Cambridge","Massachusetts","02138",{"type":56,"coordinates":75},[76,77],-71.10561,42.3751,{"lat":77,"lon":76},[80,84],{"name":81,"role":39,"phone":82,"phoneExt":26,"email":83},"Elly Pichardo, MD","617-952-6158","epichardo@mgb.org",{"name":85,"role":39,"phone":26,"phoneExt":26,"email":86},"Felipe Fregni, MD, PhD","Fregni.Felipe@mgh.harvard.edu",{"facility":88,"status":49,"city":89,"state":90,"zip":91,"country":53,"countryCode":54,"cosmosGeoPoint":92,"geoPoint":96,"contacts":97},"University Hospitals Cleveland Medical Center\u002F Dahms Clinical Research Unit","Cleveland","Ohio","44106-1716",{"type":56,"coordinates":93},[94,95],-81.69541,41.4995,{"lat":95,"lon":94},[98,102],{"name":99,"role":39,"phone":100,"phoneExt":26,"email":101},"Salim Hayek, MD","216-983-2085","salim.hayek@uhhospitals.org",{"name":103,"role":39,"phone":26,"phoneExt":26,"email":67},"Ciro R Estebanez, MD, PhD",{"type":105,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[107],{"name":108,"class":109},"Highland Instruments, Inc.","INDUSTRY","100391602","optimization-of-nibs-for-treatment-of-addiction-100391602",false,"NCT04379115","Optimization of NIBS for Treatment of Addiction","Optimization of Non-Invasive Brain Stimulation for Treatment of Addiction","Inclusion Criteria\n\nParticipants must meet all of the following:\n\n* Provide informed consent\n* Age 18-85 years\n* Diagnosis of opioid use disorder (DSM-5) with ongoing non-prescription opioid use confirmed by self-report and urine toxicology\n* Report current opioid craving\n* Enrolled in a certified Opioid Treatment Program and receiving methadone maintenance treatment\n* Stable methadone dose prior to enrollment\n* Reside locally with no plans to relocate during the study Exclusion Criteria\n\nParticipants will be excluded if they:\n\n* Are pregnant\n* Have frequent illicit stimulant use or acute stimulant intoxication\n* Are using substances or medications that may interfere with study assessments (e.g., stimulant medications, buprenorphine-based therapies, naltrexone)\n* Have significant neurological conditions (e.g., stroke, epilepsy, brain tumor), abnormal EEG findings, history of brain surgery, significant head injury, or unexplained syncope\n* Have contraindications to noninvasive brain stimulation (e.g., metal in the head, implanted brain devices)\n* Have moderate to severe depression or active suicidal ideation\u002Fbehavior\n* Have active malignancy\n* Consume substances that could confound opioid toxicology results (e.g., poppy-seed products)","ALL","18 Years","85 Years",{"count":121,"type":122},126,"ESTIMATED","INTERVENTIONAL",[125],"NA","The purpose of this study is to assess the effects of transcranial Direct Current Stimulation (tDCS) applied in conjunction with Transcranial Ultrasound (TUS) for the treatment of addiction in opiate use disorder with chronic pain. The investigators hypothesize that there will be a decrease in drug use and improved psychosocial assessments with active stimulation, when compared to sham stimulation.",[128,129],"Opioid-use Disorder","Chronic Pain","2026-03-03",{"date":132,"type":133},"2026-03-04","ACTUAL",{"date":135,"type":133},"2021-04-04",{"date":137,"type":122},"2027-10-31",{"name":5,"class":6},3]