[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100504495":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":28,"centralContacts":32,"locations":40,"responsibleParty":58,"collaborators":60,"id":86,"slug":87,"hasResults":88,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":92,"eligibilityCriteria":93,"healthyVolunteers":88,"sex":94,"minAge":95,"maxAge":96,"enrollmentInfo":97,"targetDuration":24,"studyType":100,"phases":101,"briefSummary":103,"conditions":104,"keywords":109,"overallStatus":42,"whyStopped":24,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":121},{"fullName":5,"class":6},"University of Texas Southwestern Medical Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Sat75","EXPERIMENTAL","FiO2 will be titrated every 30 seconds by 0.2-0.3 to achieve target SpO2 that approximates the 75th percentile SpO2 observed in healthy term newborns. Percentiles are roughly based on Dawson reference curves of healthy term infants after birth.",[13],"Other: Sat75",{"label":15,"type":16,"description":17,"interventionNames":18},"Sat50","ACTIVE_COMPARATOR","FiO2 will be titrated every 30 seconds by 0.1-0.2 to achieve NRP recommended target SpO2 which approximates the 50th percentile SpO2 observed in healthy term newborns. Percentiles are roughly based on Dawson reference curves of healthy term infants after birth.",[19],"Other: Sat50",[21,25],{"type":6,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"As per the current NRP guidelines, resuscitation will be initiated with 0.3 FiO2. FiO2 will be titrated every 30 seconds by 0.2-0.3 to achieve target SpO2 that approximates the 75th percentile SpO2 observed in healthy term newborns. Percentiles are roughly based on Dawson reference curves of healthy term infants after birth. Apart from the randomly assigned target SpO2, resuscitation will follow the current NRP guidelines. Following NICU admission, all care decisions, including ventilator management, will be at the discretion of the clinical team.",[9],null,{"type":6,"name":15,"description":26,"armGroupLabels":27,"otherNames":24},"As per the current NRP guidelines, resuscitation will be initiated with 0.3 FiO2. FiO2 will be titrated every 30 seconds by 0.1-0.2 to achieve target SpO2 that approximates the 50th percentile SpO2 observed in healthy term newborns. Percentiles are roughly based on Dawson reference curves of healthy term infants after birth. Apart from the randomly assigned target SpO2, resuscitation will follow the current NRP guidelines. Following NICU admission, all care decisions, including ventilator management, will be at the discretion of the clinical team.",[15],[29],{"name":30,"affiliation":5,"role":31},"Vishal Kapadia, MD","PRINCIPAL_INVESTIGATOR",[33,37],{"name":30,"role":34,"phone":35,"phoneExt":24,"email":36},"CONTACT","2146483903","vishal.kapadia@utsouthwestern.edu",{"name":38,"role":34,"phone":35,"phoneExt":24,"email":39},"Shelby Unger, RN","shelby.unger@utsouthwestern.edu",[41],{"facility":5,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"RECRUITING","Dallas","Texas","75390","United States","US",{"type":49,"coordinates":50},"Point",[51,52],-96.80667,32.78306,{"lat":52,"lon":51},[55],{"name":56,"role":34,"phone":24,"phoneExt":24,"email":57},"Vishal Kapadia","Vishal.kapadia@utsouthwestern.edu",{"type":31,"investigatorFullName":56,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Associate Professor",[61,63,65,68,70,72,74,76,78,80,82,84],{"name":62,"class":6},"University of Alabama at Birmingham",{"name":64,"class":6},"University of Oklahoma",{"name":66,"class":67},"North Central Baptist Hospital","UNKNOWN",{"name":69,"class":6},"Sharp Mary Birch Hospital for Women & Newborns",{"name":71,"class":6},"The Woman's Hospital of Texas",{"name":73,"class":6},"Baylor College of Medicine",{"name":75,"class":6},"University of Florida Health",{"name":77,"class":6},"University of Pittsburgh Medical Center",{"name":79,"class":6},"University of Pittsburgh",{"name":81,"class":6},"University of Utah",{"name":83,"class":6},"Primary Children's Hospital",{"name":85,"class":67},"Methodist Children's Hospital","100504495","optimization-of-saturation-targets-and-resuscitation-trial-optistart-100504495",false,"NCT05849077","Optimization of Saturation Targets And Resuscitation Trial (OptiSTART)","Optimization of Saturation Targets And Resuscitation (OptiSTART): Multicenter Randomized Controlled Trial","OptiSTART","Inclusion Criteria:\n\n-Neonates with OB gestational age 22-30 weeks\n\nExclusion Criteria:\n\n* Prenatally diagnosed cyanotic congenital heart disease\n* Prenatally diagnosed congenital diaphragmatic hernia\n* Parents request no resuscitation\n* If preductal saturations can not be measured by 3 minutes after pulse oximeter sensor is applied to the newborn","ALL","0 Minutes","10 Minutes",{"count":98,"type":99},700,"ESTIMATED","INTERVENTIONAL",[102],"NA","This study is designed to answer one of the fundamental gaps in knowledge in the resuscitation of preterm infants at birth: What is the optimal target oxygen saturation (SpO2) range that increases survival without long-term morbidities? Oxygen (O2) is routinely used for the stabilization of preterm infants in the delivery room (DR), but its use is linked with mortality and several morbidities including bronchopulmonary dysplasia (BPD). To balance the need to give sufficient O2 to correct hypoxia and avoid excess O2, the neonatal resuscitation program (NRP) recommends initiating preterm resuscitation with low (≤ 30%) inspired O2 concentration (FiO2) and subsequent titration to achieve a specified target SpO2 range. These SpO2 targets are based on approximated 50th percentile SpO2 (Sat50) observed in healthy term infants. However, the optimal SpO2 targets remain undefined in the preterm infants. Recent data suggest that the current SpO2 targets (Sat50) may be too low. The investigators plan to conduct a multicenter RCT of Sat75 versus Sat50 powered for survival without BPD. The investigators will randomize 700 infants, 23 0\u002F7- 30 6\u002F7 weeks' GA, to 75th percentile SpO2 goals (Sat75, Intervention) or 50th percentile SpO2 goals (Sat50, control). Except for the SpO2 targets, all resuscitations will follow NRP guidelines including an initial FiO2 of 0.3. In Aim 1, the investigators will determine whether targeting Sat75 compared to Sat50 increases survival without lung disease (BPD). In addition, the investigators will compare the rates of other major morbidities such as IVH. In Aim 2, the investigators will determine whether targeting Sat75 compared to Sat50 increases survival without neurodevelopmental impairment at 2 years of age. In Aim 3, the investigators will determine whether targeting Sat75 compared to Sat50 decreases oxidative stress.",[105,106,107,108],"Premature Infants","Bronchopulmonary Dysplasia","Intraventricular Hemorrhage","Neurodevelopmental Outcomes",[110,111],"neonatal resuscitation","oxygen","2025-07-30",{"date":114,"type":115},"2025-08-05","ACTUAL",{"date":117,"type":115},"2024-02-26",{"date":119,"type":99},"2029-04-01",{"name":5,"class":6},1]