[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100626783":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":11,"centralContacts":35,"locations":11,"responsibleParty":41,"collaborators":11,"id":45,"slug":46,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":47,"sex":53,"minAge":54,"maxAge":11,"enrollmentInfo":55,"targetDuration":11,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":65,"overallStatus":69,"whyStopped":11,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":11},{"fullName":5,"class":6},"Air Force Military Medical University, China","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"restrictive","EXPERIMENTAL",null,[13],"Other: restrictive fluid infusion",{"label":15,"type":10,"description":11,"interventionNames":16},"Restrictive plus preload",[13,17],"Other: preload",{"label":19,"type":10,"description":11,"interventionNames":20},"restrictive plus preload plus nitro",[13,17,21],"Other: nitro",[23,27,31],{"type":6,"name":24,"description":25,"armGroupLabels":26,"otherNames":11},"restrictive fluid infusion","Fluid infusion is restricted at 2 ml·kg- 1·h- 1 from the moment the patient arrive in the operating room to immediately after the liver lesions are removed",[15,9,19],{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":11},"preload","6 ml·kg- 1·h- 1 of hydroxyethyl starch solution is infused before anesthesia",[15,19],{"type":6,"name":32,"description":33,"armGroupLabels":34,"otherNames":11},"nitro","Nitroglycerin is infused from start of anesthesia to immediately after the liver lesions are removed.The starting infusion rates of nitroglycerin is 0.5 μg·kg- 1·min- 1 . If the speed of administration requires adjustment, nitroglycerin is added or decreased by 0.1 μg·kg- 1·min- 1.",[19],[36],{"name":37,"role":38,"phone":39,"phoneExt":11,"email":40},"Zhihong Lu","CONTACT","86-13891975018","deerlu23@163.com",{"type":42,"investigatorFullName":43,"investigatorTitle":44,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"SPONSOR_INVESTIGATOR","Zhihong LU","Professor","100626783","optimized-strict-fluid-management-helps-improve-endpoints-after-liver-dissection-100626783",false,"NCT07440121","Optimized Strict Fluid Management Helps Improve Endpoints After Liver Dissection","The Effect of Different Fluid Therapy on Major Postoperative Morbidity in Patients Undergoing Non-donor Hepatectomy: a Pilot Trial","SHIELD-pilot","Inclusion Criteria:\n\n* scheduled for elective hepatectomy under general anesthesia\n* age ≥18 yrs old\n\nExclusion Criteria:\n\n* American society of anesthesiologists status over 3\n* existed kidney disease or renal dysfunction\n* severe cardiac or respiratory dysfunction\n* neurological or psychiatric disease\n* Child-Pugh class C (score 10-15)","ALL","18 Years",{"count":56,"type":57},90,"ESTIMATED","INTERVENTIONAL",[60],"NA","During hepatectomy, surgeons often prefer to restrict fluid intake, believing that this can lower central venous pressure (CVP) and reduce intraoperative blood loss. However, fluid restriction may lead to inadequate perfusion of vital organs and even contribute to postoperative organ dysfunction, such as acute kidney injury (AKI). Therefore, this study aims to compare the effects of restrictive versus liberal fluid therapy on major complications following hepatectomy.",[63,64],"Anesthesia","Surgery",[66,67,68],"fluid therapy","hepatectomy","acute kidney injury","NOT_YET_RECRUITING","2026-02-25",{"date":72,"type":73},"2026-02-27","ACTUAL",{"date":75,"type":57},"2026-04-02",{"date":77,"type":57},"2027-02-02",{"name":43,"class":6}]