[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100564445":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":33,"locations":39,"responsibleParty":88,"collaborators":90,"id":94,"slug":95,"hasResults":96,"nctId":97,"briefTitle":98,"officialTitle":98,"acronym":25,"eligibilityCriteria":99,"healthyVolunteers":96,"sex":100,"minAge":101,"maxAge":25,"enrollmentInfo":102,"targetDuration":25,"studyType":105,"phases":106,"briefSummary":108,"conditions":109,"keywords":111,"overallStatus":42,"whyStopped":25,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":124},{"fullName":5,"class":6},"University of Michigan","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"D-THIO (Deprescribing Thyroid Hormone In Older Adults)","EXPERIMENTAL","D-THIO is an innovative adapted multilevel intervention.\n\nProviders in the intervention arm will receive: 1) an introductory letter, and 2) the D-THIO pharmaceutical opinion via EMR-compatible correspondence.\n\nAfter randomization of their treating providers, patients in the intervention arm will receive a study packet including: 1) introductory letter, and 2) the D-THIO patient brochure (educational EMPOWER brochure).",[13],"Behavioral: D-THIO (Deprescribing Thyroid Hormone In Older Adults)",{"label":15,"type":16,"description":17,"interventionNames":18},"Enhanced usual care","ACTIVE_COMPARATOR","This arm will receive enhanced usual care.\n\nProviders in the control arm will receive: 1) an introductory letter signed by the PI and site-PIs, and 2) the ATA hypothyroidism pocket card via EMR.\n\nPatients in the control arm will receive a study packet including: 1) introductory letter, and 2) the ATA patient brochure.",[19],"Behavioral: Enhanced usual care",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","D-THIO consists of evidence-based pharmaceutical opinion letters to providers advising deprescribing for their patients 65 years and older with thyroid hormone overtreatment\u002Fmisuse and EMPOWER (\"Eliminating Medications through Patient Ownership of End Results\") brochures to their patients.",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"American Thyroid Association \\[ATA\\] provider guidelines, ATA patient brochure",[15],[30],{"name":31,"affiliation":5,"role":32},"Maria Papaleontiou","PRINCIPAL_INVESTIGATOR",[34],{"name":35,"role":36,"phone":37,"phoneExt":25,"email":38},"Brittany Gay","CONTACT","734-763-8608","bbartol@umich.edu",[40,61,72],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"University of California San Francisco","RECRUITING","San Francisco","California","94143","United States","US",{"type":49,"coordinates":50},"Point",[51,52],-122.41942,37.77493,{"lat":52,"lon":51},[55,59],{"name":56,"role":36,"phone":57,"phoneExt":25,"email":58},"Zoe Cheng","628-977-9851","Zoe.Cheng@ucsf.edu",{"name":60,"role":32,"phone":25,"phoneExt":25,"email":25},"Jennifer Perkins, MD",{"facility":5,"status":42,"city":62,"state":63,"zip":64,"country":46,"countryCode":47,"cosmosGeoPoint":65,"geoPoint":69,"contacts":70},"Ann Arbor","Michigan","48109",{"type":49,"coordinates":66},[67,68],-83.74088,42.27756,{"lat":68,"lon":67},[71],{"name":35,"role":36,"phone":37,"phoneExt":25,"email":38},{"facility":73,"status":42,"city":74,"state":63,"zip":75,"country":46,"countryCode":47,"cosmosGeoPoint":76,"geoPoint":80,"contacts":81},"Henry Ford Health System","Detroit","48202",{"type":49,"coordinates":77},[78,79],-83.04575,42.33143,{"lat":79,"lon":78},[82,86],{"name":83,"role":36,"phone":84,"phoneExt":25,"email":85},"Araceli Ambers","313-916-3906","AAMBERS1@hfhs.org",{"name":87,"role":32,"phone":25,"phoneExt":25,"email":25},"Arti Bhan, MD",{"type":32,"investigatorFullName":31,"investigatorTitle":89,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Associate Professor of Internal Medicine and Research Associate Professor at the Institute of Gerontology",[91],{"name":92,"class":93},"National Institute on Aging (NIA)","NIH","100564445","optimizing-care-for-older-adults-through-thyroid-hormone-deprescribing-100564445",false,"NCT06629272","Optimizing Care for Older Adults Through Thyroid Hormone Deprescribing","Patient Eligibility:\n\nInclusion Criteria:\n\n1. age 65 years and older\n2. on thyroid hormone therapy and have a serum Thyroid-stimulating hormone (TSH) \\\u003C0.5 mIU\u002FL or are on thyroid hormone therapy for an inappropriate indication\n3. English speaking\n4. without cognitive impairment\n\nExclusion Criteria:\n\n1\\) Patients with a diagnosis of thyroid cancer, secondary hypothyroidism, history of total thyroidectomy or hospitalization in the past 3 months will be excluded.\n\nProvider eligibility:\n\nInclusion: Primary care physicians, endocrinologists, geriatricians, and Advanced Practice Providers (APPs) who practice at University of Michigan, Henry Ford Health System or University of California San Fransico (UCSF) and who prescribe thyroid hormone for eligible patients identified above will be eligible for study participation.\n\nExclusion: Providers who don't prescribe thyroid hormone.","ALL","65 Years",{"count":103,"type":104},900,"ESTIMATED","INTERVENTIONAL",[107],"NA","The proposed study focuses on testing a novel adapted evidence-based multilevel intervention, Deprescribing Thyroid Hormone In Older Adults (D-THIO), to support thyroid hormone deprescribing (dose de-escalation and\u002For discontinuation) in older adults with thyroid hormone overtreatment and\u002For misuse and reduce patient harm. Findings from this study will lay the groundwork for broad implementation of D-THIO and serve as a model for deprescribing inappropriate medications for other endocrine conditions and conditions with biochemical monitoring.",[110],"Hypothyroidism",[112,113,114],"thyroid hormone overtreatment and misuse","older adults","deprescribing","2026-02-10",{"date":117,"type":118},"2026-02-13","ACTUAL",{"date":120,"type":118},"2024-12-02",{"date":122,"type":104},"2029-04",{"name":5,"class":6},3]