[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100624852":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":34,"centralContacts":38,"locations":43,"responsibleParty":62,"collaborators":21,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":68,"acronym":21,"eligibilityCriteria":69,"healthyVolunteers":66,"sex":70,"minAge":71,"maxAge":21,"enrollmentInfo":72,"targetDuration":21,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":21,"overallStatus":46,"whyStopped":21,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"M.D. Anderson Cancer Center","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"MRI Scan with Gadavist (gadobutrol) \u002F VUEWAY (gadopiclenol)","Participants found to be eligible to take part in this study and agree to take part, will have brain MRI scans as part of standard of care. Then, within a week (preferably within 48 hours) of the participants routine brain MRI scans, you will have LMD-focused brain MRI scans with gadopiclenol contrast. Specifically, MRI scans will be done immediately after a small amount of gadopiclenol is given through an IV catheter placed into a vein, and then at 10 and 30 minutes thereafter. Then, a second dose of gadopiclenol will be given, and MRI scans will be done immediately after. The MRI scans performed for research purposes will take approximately 50 minutes to complete. You will be followed by routing clinical and imaging guidelines for 6 months or until the confirmation of LMD (whichever comes first).",[12,13,14],"Procedure: MRI Scan","Drug: VUEWAY","Drug: Gadavist",[16,22,29],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":21},"PROCEDURE","MRI Scan","Given during standard of care",[9],null,{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"DRUG","VUEWAY","Given by IV",[9],[28],"gadopiclenol",{"type":23,"name":30,"description":25,"armGroupLabels":31,"otherNames":32},"Gadavist",[9],[33],"gadobutrol",[35],{"name":36,"affiliation":5,"role":37},"Rami Eldaya, MD","PRINCIPAL_INVESTIGATOR",[39],{"name":36,"role":40,"phone":41,"phoneExt":21,"email":42},"CONTACT","(713) 745-2945","reldaya@mdanderson.org",[44],{"facility":45,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"MD Anderson Cancer Center","RECRUITING","Houston","Texas","77030","United States","US",{"type":53,"coordinates":54},"Point",[55,56],-95.36327,29.76328,{"lat":56,"lon":55},[59,61],{"name":36,"role":40,"phone":60,"phoneExt":21,"email":42},"713-745-2945",{"name":36,"role":37,"phone":21,"phoneExt":21,"email":21},{"type":63,"investigatorFullName":21,"investigatorTitle":21,"investigatorAffiliation":21,"oldNameTitle":21,"oldOrganization":21},"SPONSOR","100624852","optimizing-contrast-dose-and-scanning-parameters-for-detection-of-leptomeningeal-disease-100624852",false,"NCT07415018","Optimizing Contrast Dose and Scanning Parameters for Detection of Leptomeningeal Disease","Inclusion Criteria:\n\n* Patients with tissue confirmed solid malignancy and standard of care brain MRI with equivocal results for LMD (questionable or possible) and negative LP CSF sampling or patients with high risk clinical LMD and negative brain MR and LP CSF sampling. Initially, we will target solid tumors, but if more patients are needed to meet the study power we will enroll liquid tumors.\n* Participants \\> 18 years of age.\n* Participants are able to consent.\n\nExclusion Criteria:\n\n* Participants with CSF sampling positive for LMD or MR brain\u002Fspine with definitive evidence of LMD.\n* Participants with implantable devices that can not be scanned with MR safe mode for participant safety.\n* Pregnant participants or potentially pregnant participants are at risk of contrast on the fetus\n\nPediatric participants \\\u003C 18 years of age.","ALL","18 Years",{"count":73,"type":74},40,"ESTIMATED","INTERVENTIONAL",[77],"NA","To learn if gadopiclenol (a contrast agent) used during MRI scanning can help in the detection of early LMD.",[80],"Leptomeningeal Disease","2026-06-17",{"date":83,"type":84},"2026-06-18","ACTUAL",{"date":86,"type":84},"2026-06-10",{"date":88,"type":74},"2029-07-31",{"name":5,"class":6},1]