[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100634385":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":51,"collaborators":26,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":26,"eligibilityCriteria":59,"healthyVolunteers":55,"sex":60,"minAge":26,"maxAge":61,"enrollmentInfo":62,"targetDuration":26,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":73,"overallStatus":82,"whyStopped":26,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Children's Hospital of Fudan University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Early Nutritional Improvement Group","EXPERIMENTAL","The intervention group will receive an additional nutritional bundle based on the routine nutritional strategies for the control group. The bundle includes individualized and precise human milk feeding, early enteral zinc supplementation, and routine parenteral carnitine supplementation.",[13],"Drug: A nutritional improving bundle for the intervention group",{"label":15,"type":16,"description":17,"interventionNames":18},"Conventional Nutritional Strategies Group","ACTIVE_COMPARATOR","The subjects of control group were retrospectively included using historical data, they only received the conventional nutritional strategies at that time without including the bundle of the intervention group.",[19],"Drug: Routine nutritional strategies for the control group",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","A nutritional improving bundle for the intervention group","The intervention group will receive an additional nutritional bundle based on the routine nutritional strategies for the control group. The bundle include individualized and precise breastfeeding, early enteral zinc supplementation, and routine parenteral carnitine supplementation.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Routine nutritional strategies for the control group","The control group consisted of retrospectively enrolled subjects matched with the intervention group. They received only the nutritional supplementation strategies routinely used in clinical practice at the time, including standard human milk fortification, zinc supplementation based on serological markers, and lower-dose carnitine supplementation.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Junyan Han, Doctor","CONTACT","86 13524675569","jyhan17@fudan.edu.cn",[38],{"facility":5,"status":26,"city":39,"state":26,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Shanghai","201102","China","CN",{"type":44,"coordinates":45},"Point",[46,47],121.45806,31.22222,{"lat":47,"lon":46},[50],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},{"type":52,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100634385","optimizing-early-nutrition-management-of-extremely-andor-very-preterm-infants-100634385",false,"NCT07538999","Optimizing Early Nutrition Management of Extremely and\u002For Very Preterm Infants","Optimizing Early Nutrition Management of Extremely and\u002For Very Preterm Infants Based on Best Clinical Practice: a Real Word Study","Inclusion Criteria for intervention group:\n\n* (1) Admitted to the Neonatal Department of Children's Hospital of Fudan University during the study period.\n* (2) Preterm infants with a gestational age \\\u003C 32 weeks or a birth weight \\\u003C 1500 g.\n* (3) Admitted to the study center within 24 hours after birth.\n* (4) Obtained informed consent from family members. Exclusion Criteria for intervention group\n* (1) Newborns with severe congenital diseases, severe congenital malformations, chromosomal abnormalities, or genetic metabolic diseases.\n* (2) Death or discharge within two weeks after birth.\n\nInclusion Criteria for control group:\n\n* (1) Admitted to the Neonatal Department of Children's Hospital of Fudan University from January 2025 to December 2025.\n* (2) Preterm infants with a gestational age \\\u003C 32 weeks or a birth weight \\\u003C 1500 g.\n* (3) Admitted to the study center within 24 hours after birth. Exclusion Criteria for control group\n* (1) Newborns with severe congenital diseases, severe congenital malformations, chromosomal abnormalities, or genetic metabolic diseases.\n* (2) Death or discharge within two weeks after birth.","ALL","1 Day",{"count":63,"type":64},200,"ESTIMATED","INTERVENTIONAL",[67],"NA","A clinical quality improvement bundle on early nutrition supplementation is developed to improving the clinical outcomes (including growth, organ function, and neurodevelopment outcomes) of extremely and\u002For very preterm infants. This bundle consists of three aspects: individualized and precise human milk feeding, early enteral zinc supplementation, and routine parenteral carnitine supplementation.",[70,71,72],"Nutrition Intervention","Quality Improvement","Preterm Infant",[74,75,76,77,78,79,80,81],"preterm infants","nutrition","bundle","zinc supplementation","carnitine supplementation","growth","outcomes","human milk feeding","NOT_YET_RECRUITING","2026-04-13",{"date":85,"type":86},"2026-04-20","ACTUAL",{"date":88,"type":64},"2026-04-01",{"date":90,"type":64},"2029-12-31",{"name":5,"class":6},1]