[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100613772":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":12,"centralContacts":12,"locations":12,"responsibleParty":37,"collaborators":12,"id":41,"slug":42,"hasResults":43,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":12,"eligibilityCriteria":47,"healthyVolunteers":43,"sex":48,"minAge":49,"maxAge":12,"enrollmentInfo":50,"targetDuration":12,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":63,"overallStatus":69,"whyStopped":12,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":12},{"fullName":5,"class":6},"Hamad Medical Corporation","INDUSTRY",[8,13,19],{"label":9,"type":10,"description":11,"interventionNames":12},"24-hour continuous feeding (control)","NO_INTERVENTION","Feeding Schedule provides continuous enteral nutrition over 24 hours with no fasting window. This standard care in many ICUs serves as the baseline for comparison with two experimental cycled feeding regimens. The feeding rate is designed to evenly deliver the total daily caloric goal across the entire period.",null,{"label":14,"type":15,"description":16,"interventionNames":17},"20-hour cycled feeding (intervention)","ACTIVE_COMPARATOR","Feeding Schedule consists of enteral nutrition delivered over 20 hours, with a structured 4-hour fasting window each day. This approach aims to balance metabolic and gastrointestinal benefits while ensuring adequate daily caloric intake. Consequently, the feeding rate is increased to meet the total caloric goal within the shorter feeding period.",[18],"Behavioral: 20-Hour Cycled Enteral Nutrition with a 4-Hour Fasting Window",{"label":20,"type":15,"description":21,"interventionNames":22},"18-hour cycled feeding (intervention)","Feeding Schedule involves enteral nutrition over an 18-hour period while incorporating a 6-hour fasting window in each 24-hour cycle. This structure is designed to test a more intense intermittent fasting regimen, aiming to enhance physiological benefits by better aligning with circadian rhythms. The expectations include improved metabolic control, enhanced gastrointestinal motility, and reduced infection rates, with careful monitoring for reduced caloric intake risk. Consequently, the feeding rate is increased to meet daily caloric goals within the 18-hour timeframe, resulting in the most intensive feeding schedule among the three examined arms.",[23],"Behavioral: 18-Hour Cycled Enteral Nutrition with a 6-Hour Fasting Window",[25,32],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"BEHAVIORAL","20-Hour Cycled Enteral Nutrition with a 4-Hour Fasting Window","20-Hour Cycled Enteral Nutrition with a 4-Hour Fasting Window (Intervention 1) Objective: To evaluate the physiological benefits of a structured daily fasting period while maintaining a conservative approach to caloric delivery.",[14],[31],"Group Intervention 1",{"type":26,"name":33,"description":21,"armGroupLabels":34,"otherNames":35},"18-Hour Cycled Enteral Nutrition with a 6-Hour Fasting Window",[20],[36],"Group Intervention 2",{"type":38,"investigatorFullName":39,"investigatorTitle":40,"investigatorAffiliation":5,"oldNameTitle":12,"oldOrganization":12},"PRINCIPAL_INVESTIGATOR","Mr.Mutaz Ibrahim Omar Othman","Charge Nurse","100613772","optimizing-enteral-nutrition-regimen-for-critically-ill-patients-100613772",false,"NCT07270939","Optimizing Enteral Nutrition Regimen for Critically Ill Patients","Optimizing Enteral Nutrition: A Comparative Study of 18-Hour, 20-Hour, and 24-Hour","Inclusion Criteria\n\nParticipants must meet ALL of the following criteria to be eligible for the study:\n\n1. Patients aged ≥ 18 years.\n2. Patients expected to require enteral nutrition (EN) for ≥ 7 days.\n3. Critically ill, mechanically ventilated patients in the ICU.\n4. New patients initiating EN in the critical care unit.\n5. Patients receiving EN via:\n\n   * a nasogastric (NG) tube.\n   * orogastric (OG) feeding tube.\n\nExclusion Criteria:\n\n1. Patients with contraindications to enteral feeding or pre-existing gastrointestinal disorders, including:\n\n   * Active GI bleeding.\n   * Progressive GI disease.\n   * Recent GI tract resection.\n2. Indication for a special diet formula.\n3. Need for a large volume of feeding (as determined by the clinical team).\n4. Pre-existing hepatic failure.\n5. Use of a nasojejunal tube, gastrostomy, or jejunostomy.\n6. Pregnancy confirmed via β-hCG testing for women of childbearing potential.\n7. Insulin-dependent diabetes mellitus.","ALL","18 Years",{"count":51,"type":52},150,"ESTIMATED","INTERVENTIONAL",[55],"NA","Clinical Trial The goal of this clinical trial is to learn whether different enteral feeding cycles (18-hour, 20-hour, or standard 24-hour continuous feeding) improve outcomes for critically ill ICU patients who need tube feeding. It will also look at tolerance, nutrition delivery, and safety.\n\nThe main questions it aims to answer are:\n\nDo shorter feeding cycles (with fasting windows) reduce ICU length of stay?\n\nDo they lower the risk of infections like ventilator-associated pneumonia?\n\nHow do they affect calorie delivery, blood sugar control, and gastrointestinal tolerance?\n\nResearchers will compare:\n\nContinuous 24-hour feeding (standard care)\n\n20-hour feeding with a 4-hour fasting window\n\n18-hour feeding with a 6-hour fasting window\n\nParticipants will:\n\nBe critically ill adults in the ICU who require at least 7 days of enteral feeding\n\nBe randomized to one of the three feeding schedules\n\nReceive daily monitoring of calories, protein, blood sugar, and GI tolerance\n\nHave outcomes measured, including ICU length of stay, infections, metabolic control, and feeding tolerance",[58,59,60,61,62],"Critical Illness","Enteral Nutrition","Ventilator Associated Pneumonia","Hyperglycemia","Feeding Intolerance",[64,65,66,67,68],"Cyclic feeding","Feeding window","Critical care nutrition","Gastrointestinal tolerance","Nutritional adequacy","NOT_YET_RECRUITING","2025-11-26",{"date":72,"type":73},"2025-12-08","ACTUAL",{"date":75,"type":52},"2025-12-30",{"date":77,"type":52},"2026-11-30",{"name":5,"class":6}]