[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100631957":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":23,"centralContacts":34,"locations":40,"responsibleParty":72,"collaborators":74,"id":82,"slug":83,"hasResults":84,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":12,"eligibilityCriteria":88,"healthyVolunteers":84,"sex":89,"minAge":90,"maxAge":12,"enrollmentInfo":91,"targetDuration":12,"studyType":94,"phases":95,"briefSummary":97,"conditions":98,"keywords":104,"overallStatus":106,"whyStopped":12,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":116},{"fullName":5,"class":6},"Seattle Institute for Biomedical and Clinical Research","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"No Intervention: Usual care","NO_INTERVENTION","HIV+ Patients in this arm will receive usual care from their provider",null,{"label":14,"type":6,"description":15,"interventionNames":16},"Proactive E-consult","HIV+ patients randomized into in this arm will have proactive E-consults with pharmacist recommendations sent to enrolled providers prior to appointments",[17],"Other: E-consult",[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":12},"E-consult","Pharmacist-driven e-consults to providers of people with HIV (PWH) to improve guideline-concordant care and decrease population risk of pneumonia in PWH",[14],[24,28,31],{"name":25,"affiliation":26,"role":27},"Kristina A. Crothers, MD","VA Puget Sound Health Care System","PRINCIPAL_INVESTIGATOR",{"name":29,"affiliation":30,"role":27},"Ken M Kunisaki, MD,MS","Boise VA Medical Center",{"name":32,"affiliation":33,"role":27},"Orly Vardeny, PharmD","Minneapolis Veterans Affairs Medical Center",[35],{"name":36,"role":37,"phone":38,"phoneExt":12,"email":39},"John R Kundzins, BS","CONTACT","206-277-1182","OPTIMIZEStudyTeam@va.gov",[41,53,63],{"facility":30,"status":12,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":12},"Boise","Idaho","83702","United States","US",{"type":48,"coordinates":49},"Point",[50,51],-116.20345,43.6135,{"lat":51,"lon":50},{"facility":54,"status":12,"city":55,"state":56,"zip":57,"country":45,"countryCode":46,"cosmosGeoPoint":58,"geoPoint":62,"contacts":12},"Minneapolis VA Health Care System","Minneapolis","Minnesota","55417",{"type":48,"coordinates":59},[60,61],-93.26384,44.97997,{"lat":61,"lon":60},{"facility":26,"status":12,"city":64,"state":65,"zip":66,"country":45,"countryCode":46,"cosmosGeoPoint":67,"geoPoint":71,"contacts":12},"Seattle","Washington","98108",{"type":48,"coordinates":68},[69,70],-122.33207,47.60621,{"lat":70,"lon":69},{"type":73,"investigatorFullName":12,"investigatorTitle":12,"investigatorAffiliation":12,"oldNameTitle":12,"oldOrganization":12},"SPONSOR",[75,77,78,79],{"name":26,"class":76},"FED",{"name":33,"class":76},{"name":30,"class":76},{"name":80,"class":81},"West Haven VA Medical Center","UNKNOWN","100631957","optimizing-medications-and-lung-health-in-people-with-hiv-through-pharmacist-led-proactive-e-consults-100631957",false,"NCT07507435","Optimizing Medications and Lung Health in People With HIV Through Pharmacist-led Proactive E-Consults","Optimizing Medications and Lung Health in People With HIV Through Pharmacist-led Proactive E-Consults (OPTIMIZE Lung-HIV)","Inclusion Criteria:\n\n* PWH on ART for 6 months, receiving care at the VA, and one or more of the following:\n\n  1. Actively smoking\n  2. Prescribed ICS for \\>90 days\n  3. Prescribed a PPI for \\>90 days\n\n     Exclusion Criteria:\n* Enrolled in palliative care or hospice\n* if a non-VA provider is the main primary care or HIV provider\n* Are currently participating in a separate ongoing interventional clinical trial","ALL","18 Years",{"count":92,"type":93},480,"ESTIMATED","INTERVENTIONAL",[96],"NA","People with HIV (PWH) continue to experience elevated risk of community-acquired pneumonia despite effective antiretroviral therapy. Pneumonia contributes to hospitalization, respiratory failure, cardiovascular complications, long-term decline in lung function, and mortality. Several modifiable factors increase this risk, including active smoking, inadequate receipt of respiratory vaccinations, and inappropriate or prolonged use of inhaled corticosteroids (ICS) or proton-pump inhibitors (PPIs).\n\nOPTIMIZE Lung-HIV is a multicenter, patient-level randomized controlled hybrid Type 1 effectiveness-implementation trial evaluating whether a proactive, pharmacist-led E-consult intervention can improve evidence-based pulmonary pharmacotherapy for PWH. Pharmacists will review electronic health records, generate tailored recommendations, and pre-enter orders related to smoking cessation pharmacotherapy, vaccinations, and deprescribing of ICS or PPIs. Providers may enact or modify recommendations as clinically appropriate.\n\nThe trial will assess the proportion of recommendations enacted within 3 months (primary outcome) and at 12 months (maintenance) and will use mixed methods guided by CFIR and RE-AIM to evaluate adoption, feasibility, acceptability, and implementation barriers and facilitators.",[99,100,101,102,103],"HIV","Inhaled Corticosteroid","Proton Pump Inhibitor","Smoking Cessation","Pneumonia",[105,20,99],"Pharmacist","NOT_YET_RECRUITING","2026-03-26",{"date":109,"type":110},"2026-04-02","ACTUAL",{"date":112,"type":93},"2026-05",{"date":114,"type":93},"2029-09",{"name":5,"class":6},3]