[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100624348":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":10,"centralContacts":31,"locations":10,"responsibleParty":37,"collaborators":10,"id":41,"slug":42,"hasResults":43,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":49,"sex":50,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":10,"studyType":56,"phases":10,"briefSummary":57,"conditions":58,"keywords":10,"overallStatus":60,"whyStopped":10,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":10},{"fullName":5,"class":6},"IRCCS San Raffaele","OTHER",[8,14,18,22],{"label":9,"type":10,"description":11,"interventionNames":12},"HV\u002FHC",null,"High vacuum (650 mmHg) \u002F High cut rate (10,000 cpm)",[13],"Other: Simulated vitrectomy",{"label":15,"type":10,"description":16,"interventionNames":17},"HV\u002FLC","High vacuum (650 mmHg) \u002F Low cut rate (800 cpm)",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"LV\u002FHC","Low vacuum (300 mmHg) \u002F High cut rate (10,000 cpm)",[13],{"label":23,"type":10,"description":24,"interventionNames":25},"LV\u002FLC","Low vacuum (300 mmHg) \u002F Low cut rate (800 cpm)",[13],[27],{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":10},"Simulated vitrectomy","The simulated vitrectomy is performed using the cutter handpiece, a microcannulated probe that combines a pneumatic cutting mechanism and a controlled aspiration system. The probe is directly inserted into the collection tube (ex-vivo model), allowing mechanical fragmentation and aspiration of donor suspended cells under the selected physical parameters (vacuum and cut rate, according to protocol).",[9,15,19,23],[32],{"name":33,"role":34,"phone":35,"phoneExt":10,"email":36},"Adelaide Pina","CONTACT","+39 02 2643 3598","oculistica@hsr.it",{"type":38,"investigatorFullName":39,"investigatorTitle":40,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Lorenzo Iuliano","Dr.","100624348","optimizing-operational-parameters-for-diagnostic-vitrectomy-100624348",false,"NCT07408466","Optimizing Operational Parameters for Diagnostic Vitrectomy","Optimizing Operational Parameters to Preserve Cellular Integrity During Diagnostic Vitrectomy: An Ex-Vivo Pilot Study With Blinded Outcome Assessment","CELLVIT","Inclusion Criteria:\n\n* Provision of written informed consent authorizing the anonymized research use of residual blood samples.\n* Age 18-65 years at the time of donation.\n* Eligibility for routine whole blood donation, according to the institutional and national standards of the Blood Transfusion Center.\n* Good general health, as per standard donor screening procedures.\n\nExclusion Criteria:\n\nNo additional exclusion criteria are defined beyond standard blood donation regulations. Exclusion from the study will therefore coincide with ineligibility for blood donation according to institutional protocols (e.g., due to infection, hematologic disease, recent surgery, or medication use that affects blood composition).",true,"ALL","18 Years","65 Years",{"count":54,"type":55},100,"ESTIMATED","OBSERVATIONAL","Single-center ex-vivo study using blood samples from healthy donors processed through a 25-gauge vitrectomy system. The study compares four combinations of operational parameters (vacuum pressure and cut rate) to evaluate their impact on cellular recovery and morphological preservation. Pre- and post-procedure complete blood counts and cytology smears will be analyzed to identify the settings that minimize cell loss and mechanical damage, with the ultimate goal of optimizing diagnostic yield in vitreoretinal lymphoma (VRL) vitrectomy.",[59],"No Disease or Condition is Being Studied","NOT_YET_RECRUITING","2026-02-12",{"date":63,"type":64},"2026-02-17","ACTUAL",{"date":66,"type":55},"2026-04",{"date":68,"type":55},"2026-12",{"name":5,"class":6}]