[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100615355":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":43,"centralContacts":44,"locations":50,"responsibleParty":68,"collaborators":43,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":78,"sex":79,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":43,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":93,"overallStatus":100,"whyStopped":43,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"Second Affiliated Hospital, School of Medicine, Zhejiang University","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Postoperative Root Canal Therapy (PRCT)","ACTIVE_COMPARATOR","Participants in this group will receive conventional autotransplantation of a fully developed third molar. No additional apical procedure is performed on the donor tooth during surgery. Standard non-surgical root canal therapy will be initiated and completed within 2-4 weeks after the transplantation procedure.",[13],"Procedure: Postoperative Root Canal Therapy",{"label":15,"type":16,"description":17,"interventionNames":18},"Apical Surgery with Retrograde Filling (AS)","EXPERIMENTAL","Participants in this group will receive autotransplantation of a fully developed third molar with intraoperative apical surgery. During surgery (ex vivo), the root apex (approximately 3mm) of the donor tooth is resected, followed by retrograde cavity preparation and obturation with a biocompatible material (e.g., MTA). Standard non-surgical root canal therapy will also be initiated and completed within 2-4 weeks postoperatively.",[19],"Procedure: Intraoperative Apical Surgery with Retrograde Filling",{"label":21,"type":16,"description":22,"interventionNames":23},"Root-End Resection Only (RER)","Participants in this group will receive autotransplantation of a fully developed third molar with intraoperative root-end resection only. During surgery (ex vivo), the root apex (approximately 3mm) is resected to enlarge the apical foramen, but no retrograde preparation or filling is performed. No prophylactic root canal therapy is planned postoperatively. Remedial root canal therapy will be provided only if signs\u002Fsymptoms of pulp necrosis or apical periodontitis develop during follow-up.",[24],"Procedure: Intraoperative Root-End Resection",[26,33,39],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"PROCEDURE","Postoperative Root Canal Therapy","This intervention involves the standard non-surgical root canal treatment of the autotransplanted tooth. It is performed after the surgical transplantation procedure, typically initiated within 2-4 weeks postoperatively. The procedure includes pulp extirpation, biomechanical preparation, disinfection, and obturation of the root canal system using standard techniques and materials (e.g., gutta-percha and sealer).",[9],[32],"PRCT",{"type":27,"name":34,"description":35,"armGroupLabels":36,"otherNames":37},"Intraoperative Apical Surgery with Retrograde Filling","This surgical intervention is performed on the donor tooth during the transplantation procedure, while the tooth is outside the mouth (ex vivo). It consists of: 1) Resection of approximately 3mm of the root apex; 2) Preparation of a retrograde cavity at the resected apex; and 3) Obturation of this cavity with a biocompatible material, such as Mineral Trioxide Aggregate (MTA), to achieve a seal. This is followed by postoperative root canal therapy (as described in Intervention 1).",[15],[38],"AS",{"type":27,"name":40,"description":41,"armGroupLabels":42,"otherNames":43},"Intraoperative Root-End Resection","This surgical intervention is performed on the donor tooth during the transplantation procedure, while the tooth is outside the mouth (ex vivo). It involves the resection of approximately 3mm of the root apex only, with the aim of enlarging the apical foramen. Crucially, no retrograde preparation or filling is performed. Postoperatively, no prophylactic (preventive) root canal therapy is planned. The goal is to promote revascularization and survival of the pulp. Remedial root canal therapy is provided only if clinical or radiographic signs of pulp necrosis or apical periodontitis develop during follow-up.",[21],null,[45],{"name":46,"role":47,"phone":48,"phoneExt":43,"email":49},"Jiajia XIa","CONTACT","+8618857862012","jackey-xiaj@zju.edu.cn",[51],{"facility":52,"status":43,"city":53,"state":54,"zip":55,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":64},"The Second Affiliated Hospital of Zhejiang University School of Medicine","Hangzhou","Zhejiang","310002","China","CN",{"type":59,"coordinates":60},"Point",[61,62],120.16142,30.29365,{"lat":62,"lon":61},[65],{"name":66,"role":47,"phone":48,"phoneExt":43,"email":67},"Jiajia Xia","jackey-xia@zju.edu.cn",{"type":69,"investigatorFullName":43,"investigatorTitle":43,"investigatorAffiliation":43,"oldNameTitle":43,"oldOrganization":43},"SPONSOR","100615355","optimizing-pulp-management-in-autotransplantation-of-mature-third-molars-a-randomized-controlled-trial-100615355",false,"NCT07291531","Optimizing Pulp Management in Autotransplantation of Mature Third Molars: A Randomized Controlled Trial","Optimizing Pulp Management Strategies for Autotransplantation of Fully Developed Third Molars: A Three-Arm Randomized Controlled Trial","OPuM-ATM3","Inclusion Criteria:\n\n1. Aged 18-40 years.\n2. Requires extraction of a non-restorable first or second molar AND possesses a fully developed, morphologically healthy ipsilateral third molar as a donor tooth.\n3. Willing and able to provide written informed consent.\n\nExclusion Criteria:\n\n1. Presence of acute infection or insufficient bone volume at the recipient site.\n2. Donor tooth exhibits caries, periapical pathology, or periodontal disease.\n3. Uncontrolled systemic disease (e.g., diabetes, immunosuppression), pregnancy, or lactation.\n\n   Smoking habit of \\>10 cigarettes per day.\n4. Inability or unwillingness to comply with the long-term follow-up schedule.",true,"ALL","18 Years","40 Years",{"count":83,"type":84},360,"ESTIMATED","INTERVENTIONAL",[87],"NA","This study aims to find the best way to use your own healthy wisdom tooth to replace the bad tooth. After transplantation, how to manage the \"tooth nerve\" (dental pulp) inside the tooth is a key question. Currently, doctors have three different management strategies, but it is not clear which one is most beneficial for long-term success.\n\nThis study will compare these three strategies:\n\nPerforming standard root canal treatment (removing the tooth nerve) a few weeks after transplantation.\n\nPerforming a special procedure to treat and fill the root tip during the transplant surgery, followed by root canal treatment later.\n\nSimply trimming the root tip during the transplant surgery, hoping to preserve the vitality of the tooth nerve and thereby avoid subsequent root canal treatment.\n\nIf you agree to participate, you will be randomly assigned to one of these groups to receive treatment. Afterwards, we will need to schedule regular check-ups for you over a period of 5 years (including X-rays and examinations) to monitor the healing of the transplanted tooth, check for any problems, and assess the status of the tooth nerve.\n\nYour participation will help us identify the most effective and long-lasting treatment method, thereby benefiting future patients in similar situations.",[90,91,92],"Tooth Avulsion","Dental Pulp Diseases","Tooth, Impacted",[94,95,96,97,98,99],"Autotransplantation","Third molar","Root canal therapy","Apical surgery","Root-end resection","mature tooth","NOT_YET_RECRUITING","2025-12-07",{"date":103,"type":104},"2025-12-18","ACTUAL",{"date":106,"type":84},"2026-01",{"date":108,"type":84},"2032-06",{"name":5,"class":6},1]