[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100542954":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":27,"centralContacts":31,"locations":37,"responsibleParty":57,"collaborators":59,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":23,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":23,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":23,"overallStatus":40,"whyStopped":23,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"University of Colorado, Denver","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Non-pulsatile blood flow","ACTIVE_COMPARATOR","Non-pulsatile blood flow during cardiopulmonary bypass",[13],"Other: Non-pulsatile blood flow",{"label":15,"type":10,"description":16,"interventionNames":17},"Pulsatile blood flow","Pulsatile blood flow during cardiopulmonary bypass",[18],"Other: Pulsatile blood flow",[20,24],{"type":6,"name":9,"description":21,"armGroupLabels":22,"otherNames":23},"Non-pulsatile blood flow generated by constant centrifugal pump flow rate during cardiopulmonary bypass",[9],null,{"type":6,"name":15,"description":25,"armGroupLabels":26,"otherNames":23},"Pulsatile blood flow generated by variable centrifugal pump flow rate during cardiopulmonary bypass",[15],[28],{"name":29,"affiliation":5,"role":30},"Nathan J Clendenen, MD, MS","PRINCIPAL_INVESTIGATOR",[32],{"name":33,"role":34,"phone":35,"phoneExt":23,"email":36},"Nathan J Clendenen, MD,MS","CONTACT","3037245000","nathan.clendenen@cuanschutz.edu",[38],{"facility":39,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"University of Colorado Hospital","RECRUITING","Aurora","Colorado","80045","United States","US",{"type":47,"coordinates":48},"Point",[49,50],-104.83192,39.72943,{"lat":50,"lon":49},[53,55],{"name":54,"role":34,"phone":23,"phoneExt":23,"email":36},"Nathan Clendenen, MD MS",{"name":56,"role":30,"phone":23,"phoneExt":23,"email":23},"Nathan J Clendenen, MD MS",{"type":58,"investigatorFullName":23,"investigatorTitle":23,"investigatorAffiliation":23,"oldNameTitle":23,"oldOrganization":23},"SPONSOR",[60],{"name":61,"class":62},"National Heart, Lung, and Blood Institute (NHLBI)","NIH","100542954","optimizing-pulsatility-during-cardiopulmonary-bypass-to-reduce-acute-kidney-injury-100542954",false,"NCT06349577","Optimizing Pulsatility During Cardiopulmonary Bypass to Reduce Acute Kidney Injury","Optimizing Pulsatility During Cardiopulmonary Bypass to Reduce Acute Kidney Injury: Randomized Controlled Trial","Inclusion Criteria:\n\n* Able to provide informed consent\n* Scheduled for elective cardiac surgery with cardiopulmonary bypass\n\nExclusion Criteria\n\n* Emergency procedures\n* Scheduled for heart or lung transplantation\n* Scheduled for ventricular assist device implantation\n* Use of the Medtronic Elongated Once-Piece Arterial Cannula\n* Diagnosed with sepsis\n* Diagnosed with delirium\n* Experiencing hemodynamic instability (heart rate \\> 100 and systolic blood pressure \\\u003C 90)\n* Requiring mechanical circulatory support\n* Requiring vasoactive medications","ALL","18 Years","85 Years",{"count":74,"type":75},1100,"ESTIMATED","INTERVENTIONAL",[78],"NA","The objective is to determine the effectiveness of pulsatile flow during cardiopulmonary bypass to reduce the incidence of acute kidney injury after cardiac surgery. Investigators will also evaluate the safety and impact of pulsatile flow on clinical outcomes compared to non-pulsatile flow during cardiopulmonary bypass.",[81,82,83,84],"Acute Kidney Injury","Hemolysis","Thrombocytopenia","Surgery","2025-05-19",{"date":87,"type":88},"2025-05-21","ACTUAL",{"date":85,"type":88},{"date":91,"type":75},"2028-10",{"name":5,"class":6},1]